Nývltová E, Dietz JV, Seravalli J, Khalimonchuk O and Barrientos A: Coordination of metal center biogenesis in human cytochrome c oxidase. Nat Commun. 13:36152022. View Article : Google Scholar : PubMed/NCBI

Li F, Liu H, Wu X, Liu M, Yue Z, Liu L and Li F: Copper modulates mitochondrial oxidative phosphorylation to enhance dermal papilla cells proliferation in rex rabbits. Int J Mol Sci. 23:62092022. View Article : Google Scholar : PubMed/NCBI

Dodani SC, Domaille DW, Nam CI, Miller EW, Finney LA, Vogt S and Chang CJ: Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy. Proc Natl Acad Sci USA. 108:5980–5985. 2011. View Article : Google Scholar : PubMed/NCBI

Bhattacharyya S, Biou V, Xu W, Schlüter O and Malenka RC: A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors. Nat Neurosci. 12:172–181. 2009. View Article : Google Scholar : PubMed/NCBI

Huang S, Chen L, Bladen C, Stys PK and Zamponi GW: Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions. Mol Brain. 11:622018. View Article : Google Scholar : PubMed/NCBI

Kitazawa M, Hsu HW and Medeiros R: Copper exposure perturbs brain inflammatory responses and impairs clearance of amyloid-beta. Toxicol Sci. 152:194–204. 2016. View Article : Google Scholar : PubMed/NCBI

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J and van der Flier WM: Alzheimer's disease. Lancet. 397:1577–1590. 2021. View Article : Google Scholar : PubMed/NCBI

Zhu Z, Song M, Ren J, Liang L, Mao G and Chen M: Copper homeostasis and cuproptosis in central nervous system diseases. Cell Death Dis. 15:8502024. View Article : Google Scholar : PubMed/NCBI

Ejaz HW, Wang W and Lang M: Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches. Int J Mol Sci. 21:76602020. View Article : Google Scholar : PubMed/NCBI

Li Y, Han Y, Shu Q, Kan YK and Wang Z: Cuproptosis and copper as potential mechanisms and intervention targets in Alzheimer's disease. Biomed Pharmacother. 183:1178142025. View Article : Google Scholar : PubMed/NCBI

Schlief ML, West T, Craig AM, Holtzman DM and Gitlin JD: Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proc Natl Acad Sci USA. 103:14919–14924. 2006. View Article : Google Scholar : PubMed/NCBI

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, et al: Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 375:1254–1261. 2022. View Article : Google Scholar : PubMed/NCBI

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, et al: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 15:681–689. 2019. View Article : Google Scholar : PubMed/NCBI

Bagheri S, Squitti R, Haertlé T, Siotto M and Saboury AA: Role of copper in the onset of Alzheimer's disease compared to other metals. Front Aging Neurosci. 9:4462017. View Article : Google Scholar

Bareggi SR and Cornelli U: Clioquinol: Review of its mechanisms of action and clinical uses in neurodegenerative disorders. CNS Neurosci Ther. 18:41–46. 2012. View Article : Google Scholar

Quinn JF, Harris CJ, Cobb KE, Domes C, Ralle M, Brewer G and Wadsworth TL: A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 21:903–914. 2010. View Article : Google Scholar : PubMed/NCBI

Zhu X, Victor TW, Ambi A, Sullivan JK, Hatfield J, Xu F, Miller LM and Van Nostrand WE: Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques. Metallomics. 12:539–546. 2020. View Article : Google Scholar : PubMed/NCBI

Squitti R, Salustri C, Rongioletti M and Siotto M: Commentary: The case for abandoning therapeutic chelation of copper ions in Alzheimer's disease. Front Neurol. 8:5032017. View Article : Google Scholar : PubMed/NCBI

Linder MC and Hazegh-Azam M: Copper biochemistry and molecular biology. Am J Clin Nutr. 63:797S–811S. 1996. View Article : Google Scholar : PubMed/NCBI

Lutsenko S: Human copper homeostasis: A network of interconnected pathways. Curr Opin Chem Biol. 14:211–217. 2010. View Article : Google Scholar : PubMed/NCBI

Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP and David S: Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 22:6578–6586. 2002. View Article : Google Scholar : PubMed/NCBI

Barnham KJ and Bush AI: Metals in Alzheimer's and Parkinson's diseases. Curr Opin Chem Biol. 12:222–228. 2008. View Article : Google Scholar : PubMed/NCBI

Harris ZL, Durley AP, Man TK and Gitlin JD: Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA. 96:10812–10817. 1999. View Article : Google Scholar : PubMed/NCBI

Wapnir RA: Copper absorption and bioavailability. Am J Clin Nutr. 67(5 Suppl): 1054S–1060S. 1998. View Article : Google Scholar : PubMed/NCBI

Hunt JR and Vanderpool RA: Apparent copper absorption from a vegetarian diet. Am J Clin Nutr. 74:803–807. 2001. View Article : Google Scholar : PubMed/NCBI

Zhou B and Gitschier J: hCTR1: A human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci USA. 94:7481–7486. 1997. View Article : Google Scholar : PubMed/NCBI

Georgatsou E, Mavrogiannis LA, Fragiadakis GS and Alexandraki D: The Yeast Fre1p/Fre2p cupric reductases facilitate copper uptake and are regulated by the copper-modulated Mac1p activator. J Biol Chem. 272:13786–13792. 1997. View Article : Google Scholar : PubMed/NCBI

Ohgami RS, Campagna DR, McDonald A and Fleming MD: The Steap proteins are metalloreductases. Blood. 108:1388–1394. 2006. View Article : Google Scholar : PubMed/NCBI

Prohaska JR: Role of copper transporters in copper homeostasis. Am J Clin Nutr. 88:826S–829S. 2008. View Article : Google Scholar : PubMed/NCBI

Moriya M, Ho YH, Grana A, Nguyen L, Alvarez A, Jamil R, Ackland ML, Michalczyk A, Hamer P, Ramos D, et al: Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism. Am J Physiol Cell Physiol. 295:C708–C721. 2008. View Article : Google Scholar : PubMed/NCBI

Ramos D, Mar D, Ishida M, Vargas R, Gaite M, Montgomery A and Linder MC: Mechanism of copper uptake from blood plasma ceruloplasmin by mammalian cells. PLoS One. 11:e01495162016. View Article : Google Scholar : PubMed/NCBI

Lutsenko S: Dynamic and cell-specific transport networks for intracellular copper ions. J Cell Sci. 134:jcs2405232021. View Article : Google Scholar : PubMed/NCBI

Kim H, Son HY, Bailey SM and Lee J: Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis. Am J Physiol Gastrointest Liver Physiol. 296:G356–G364. 2009. View Article : Google Scholar :

Morgan MT, Bourassa D, Harankhedkar S, McCallum AM, Zlatic SA, Calvo JS, Meloni G, Faundez V and Fahrni CJ: Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells. Proc Natl Acad Sci USA. 116:12167–12172. 2019. View Article : Google Scholar : PubMed/NCBI

Garza NM, Griffin AT, Zulkifli M, Qiu C, Kaplan CD and Gohil VM: A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. J Biol Chem. 296:1004852021. View Article : Google Scholar : PubMed/NCBI

Furukawa Y and O'Halloran TV: Posttranslational modifications in Cu, Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis. Antioxid Redox Signal. 8:847–867. 2006. View Article : Google Scholar : PubMed/NCBI

Cotruvo JA Jr, Aron AT, Ramos-Torres KM and Chang CJ: Synthetic fluorescent probes for studying copper in biological systems. Chem Soc Rev. 44:4400–4414. 2015. View Article : Google Scholar : PubMed/NCBI

Vo TTT, Peng TY, Nguyen TH, Bui TNH, Wang CS, Lee WJ, Chen YL, Wu YC and Lee IT: The crosstalk between copper-induced oxidative stress and cuproptosis: A novel potential anticancer paradigm. Cell Commun Signal. 22:3532024. View Article : Google Scholar : PubMed/NCBI

Hatori Y and Lutsenko S: The role of copper chaperone Atox1 in coupling redox homeostasis to intracellular copper distribution. Antioxidants (Basel). 5:252016. View Article : Google Scholar : PubMed/NCBI

Itoh S, Kim HW, Nakagawa O, Ozumi K, Lessner SM, Aoki H, Akram K, McKinney RD, Ushio-Fukai M and Fukai T: Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J Biol Chem. 283:9157–9167. 2008. View Article : Google Scholar : PubMed/NCBI

Lutsenko S, Roy S and Tsvetkov P: Mammalian copper homeostasis: Physiological roles and molecular mechanisms. Physiol Rev. 105:441–491. 2025. View Article : Google Scholar :

Vanišová M, Burská D, Křížová J, Daňhelovská T, Dosoudilová Ž, Zeman J, Stibůrek L and Hansíková H: Stable COX17 downregulation leads to alterations in mitochondrial ultrastructure, decreased copper content and impaired cytochrome c oxidase biogenesis in HEK293 cells. Folia Biol (Praha). 65:181–187. 2019. View Article : Google Scholar

Palumaa P, Kangur L, Voronova A and Sillard R: Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase. Biochem J. 382:307–314. 2004. View Article : Google Scholar : PubMed/NCBI

Wijmenga C and Klomp LW: Molecular regulation of copper excretion in the liver. Proc Nutr Soc. 63:31–39. 2004. View Article : Google Scholar : PubMed/NCBI

Bjørklund G, Zou L, Peana M, Chasapis CT, Hangan T, Lu J and Maes M: The role of the thioredoxin system in brain diseases. Antioxidants (Basel). 11:21612022. View Article : Google Scholar : PubMed/NCBI

Weiss KH, Lozoya JC, Tuma S, Gotthardt D, Reichert J, Ehehalt R, Stremmel W and Füllekrug J: Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol. 173:1783–1794. 2008. View Article : Google Scholar : PubMed/NCBI

Lutsenko S, Barnes NL, Bartee MY and Dmitriev OY: Function and regulation of human copper-transporting ATPases. Physiol Rev. 87:1011–1046. 2007. View Article : Google Scholar : PubMed/NCBI

Bartee MY and Lutsenko S: Hepatic copper-transporting ATPase ATP7B: Function and inactivation at the molecular and cellular level. Biometals. 20:627–637. 2007. View Article : Google Scholar : PubMed/NCBI

Roberts EA and Sarkar B: Liver as a key organ in the supply, storage, and excretion of copper. Am J Clin Nutr. 88:851S–854S. 2008. View Article : Google Scholar : PubMed/NCBI

Yang Y, Wu J, Wang L, Ji G and Dang Y: Copper homeostasis and cuproptosis in health and disease. MedComm (2020). 5:e7242024. View Article : Google Scholar : PubMed/NCBI

Liu T, Liu Y, Zhang F and Gao Y: Copper homeostasis dysregulation promoting cell damage and the association with liver diseases. Chin Med J (Engl). 136:1653–1662. 2023. View Article : Google Scholar : PubMed/NCBI

Gupta A and Lutsenko S: Human copper transporters: Mechanism, role in human diseases and therapeutic potential. Future Med Chem. 1:1125–1142. 2009. View Article : Google Scholar

Collins JF, Prohaska JR and Knutson MD: Metabolic crossroads of iron and copper. Nutr Rev. 68:133–147. 2010. View Article : Google Scholar : PubMed/NCBI

Pajarillo EAB, Lee E and Kang DK: Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper. Anim Nutr. 7:750–761. 2021. View Article : Google Scholar : PubMed/NCBI

Holloway ZG, Velayos-Baeza A, Howell GJ, Levecque C, Ponnambalam S, Sztul E and Monaco AP: Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps. Mol Biol Cell. 24:1735–1748. S1–S8. 2013. View Article : Google Scholar : PubMed/NCBI

Telianidis J, Hung YH, Materia S and Fontaine SL: Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis. Front Aging Neurosci. 5:442013. View Article : Google Scholar : PubMed/NCBI

Gudekar N, Shanbhag V, Wang Y, Ralle M, Weisman GA and Petris MJ: Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess. Sci Rep. 10:78562020. View Article : Google Scholar : PubMed/NCBI

Krężel A and Maret W: The functions of metamorphic metallothioneins in zinc and copper metabolism. Int J Mol Sci. 18:12372017. View Article : Google Scholar

Zheng W and Monnot AD: Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases. Pharmacol Ther. 133:177–188. 2012. View Article : Google Scholar :

Gaier ED, Eipper BA and Mains RE: Copper signaling in the mammalian nervous system: Synaptic effects. J Neurosci Res. 91:2–19. 2013. View Article : Google Scholar

Wang Y, Li D, Xu K, Wang G and Zhang F: Copper homeostasis and neurodegenerative diseases. Neural Regen Res. 20:3124–3143. 2025. View Article : Google Scholar :

Locatelli M and Farina C: Role of copper in central nervous system physiology and pathology. Neural Regen Res. 20:1058–1068. 2025. View Article : Google Scholar

Gale J and Aizenman E: The physiological and pathophysiological roles of copper in the nervous system. Eur J Neurosci. 60:3505–3543. 2024. View Article : Google Scholar : PubMed/NCBI

Lee J, Petris MJ and Thiele DJ: Characterization of mouse embryonic cells deficient in the Ctr1 high affinity copper transporter. J Biol Chem. 277:40253–40259. 2022. View Article : Google Scholar

Rihel J: Copper on the brain. Nat Chem Biol. 14:638–639. 2018. View Article : Google Scholar : PubMed/NCBI

Burkhead JL, Gogolin Reynolds KA, Abdel-Ghany SE, Cohu CM and Pilon M: Copper homeostasis. New Phytol. 182:799–816. 2009. View Article : Google Scholar : PubMed/NCBI

Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA and Mains RE: Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci. 30:13656–13669. 2010. View Article : Google Scholar : PubMed/NCBI

Prohaska JR and Broderius M: Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice. Comp Biochem Physiol B Biochem Mol Biol. 143:360–366. 2006. View Article : Google Scholar : PubMed/NCBI

Horn D and Barrientos A: Mitochondrial copper metabolism and delivery to cytochrome c oxidase. IUBMB Life. 60:421–429. 2008. View Article : Google Scholar : PubMed/NCBI

Ruiz LM, Libedinsky A and Elorza AA: Role of copper on mitochondrial function and metabolism. Front Mol Biosc. 8:7112272021. View Article : Google Scholar

Mattie MD and Freedman JH: Copper-inducible transcription: Regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol. 286:C293–C301. 2004. View Article : Google Scholar

Kim BE, Nevitt T and Thiele DJ: Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol. 4:176–185. 2008. View Article : Google Scholar : PubMed/NCBI

Bakavayev S, Chetrit N, Zvagelsky T, Mansour R, Vyazmensky M, Barak Z, Israelson A and Engel S: Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit. Sci Rep. 9:108262019. View Article : Google Scholar :

Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas NA and Fox PL: Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J Biol Chem. 274:1116–1123. 1999. View Article : Google Scholar : PubMed/NCBI

Wang J, Zou Y, Guan R, Tan S, Su L, Zhao Z, Cao Z, Jiang K, Wang T and Zheng G: Copper supplementation alleviates hypoxia-induced ferroptosis and oxidative stress in neuronal cells. Int J Mol Med. 54:1172024. View Article : Google Scholar :

Skjørringe T, Møller LB and Moos T: Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders. Front Pharmacol. 3:1692021.

Chen L, Shen Q, Liu Y, Zhang Y, Sun L, Ma X, Song N and Xie J: Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases. Signal Transduct Target Ther. 10:312025. View Article : Google Scholar : PubMed/NCBI

Colombo E, Triolo D, Bassani C, Bedogni F, Di Dario M, Dina G, Fredrickx E, Fermo I, Martinelli V, Newcombe J, et al: Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes. Proc Natl Acad Sci USA. 118:e20258041182021. View Article : Google Scholar : PubMed/NCBI

Hilton JBW, Kysenius K, Liddell JR, Mercer SW, Hare DJ, Buncic G, Paul B, Wang Y, Murray SS, Kilpatrick TJ, et al: Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice. Metallomics. 16:mfad0722024. View Article : Google Scholar : PubMed/NCBI

Takikita S, Takano T, Narita T and Maruo Y: Increased apoptosis and hypomyelination in cerebral white matter of macular mutant mouse brain. Mol Genet Metab Rep. 4:25–29. 2015.

Zlatic S, Comstra HS, Gokhale A, Petris MJ and Faundez V: Molecular basis of neurodegeneration and neurodevelopmental defects in Menkes disease. Neurobiol Dis. 81:154–161. 2015. View Article : Google Scholar : PubMed/NCBI

Hatori Y, Yan Y, Schmidt K, Furukawa E, Hasan NM, Yang N, Liu CN, Sockanathan S and Lutsenko S: Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun. 7:106402016. View Article : Google Scholar : PubMed/NCBI

Johnson WT, Thomas AC and Lozano AA: Maternal copper deficiency impairs the developmental expression of protein kinase C α, β and γ isoforms in neonatal rat brain. Nutr Neurosci. 3:113–122. 2000. View Article : Google Scholar

Xhabija B and Kidder BL: KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer. Semin Cancer Biol. 57:79–85. 2019. View Article : Google Scholar :

Zhong G, Wang X, Li J, Xie Z, Wu Q, Chen J, Wang Y, Chen Z, Cao X, Li T, et al: Insights into the role of copper in neurodegenerative diseases and the therapeutic potential of natural compounds. Curr Neuropharmacol. 22:1650–1671. 2024. View Article : Google Scholar :

Ramani PK and Parayil Sankaran B: Menkes Disease. StatPearls. StatPearls Publishing LLC; Treasure Island, FL: 2025

Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A and Huang X: A preliminary study of Cu exposure effects upon Alzheimer's amyloid pathology. Biomolecules. 10:4082020. View Article : Google Scholar : PubMed/NCBI

Kitazawa M, Cheng D and Laferla FM: Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 108:1550–1560. 2009. View Article : Google Scholar : PubMed/NCBI

Crouch PJ, Hung LW, Adlard PA, Cortes M, Lal V, Filiz G, Perez KA, Nurjono M, Caragounis A, Du T, et al: Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci USA. 106:381–386. 2009. View Article : Google Scholar : PubMed/NCBI

Xia Y, Tsim KWK and Wang WX: Disruption of copper redox balance and dysfunction under in vivo and in vitro Alzheimer's disease models. Environ Health (Wash). 3:238–249. 2024. View Article : Google Scholar

Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G and Schaffner W: Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. Biol Chem. 392:919–926. 2011. View Article : Google Scholar : PubMed/NCBI

Yu J, Luo X, Xu H, Ma Q, Yuan J, Li X, Chang RC, Qu Z, Huang X, Zhuang Z, et al: Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. J Alzheimers Dis. 44:455–469. 2015. View Article : Google Scholar

Sparks DL and Schreurs BG: Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci USA. 100:11065–11069. 2003. View Article : Google Scholar : PubMed/NCBI

Sparks DL, Friedland R, Petanceska S, Schreurs BG, Shi J, Perry G, Smith MA, Sharma A, Derosa S, Ziolkowski C and Stankovic G: Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J Nutr Health Aging. 10:247–254. 2006.PubMed/NCBI

Prohaska JR and Brokate B: Copper deficiency alters rat dopamine beta-monooxygenase mRNA and activity. J Nutr. 129:2147–2153. 1999. View Article : Google Scholar : PubMed/NCBI

Zeng H, Saari JT and Johnson WT: Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. J Nutr. 137:14–18. 2007. View Article : Google Scholar

Plantone D, Primiano G, Renna R, Restuccia D, Iorio R, Patanella KA, Ferilli MN and Servidei S: Copper deficiency myelopathy: A report of two cases. J Spinal Cord Med. 38:559–562. 2015. View Article : Google Scholar :

Kumar N, Gross JB Jr and Ahlskog JE: Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 63:33–39. 2004. View Article : Google Scholar : PubMed/NCBI

Jaiser SR and Winston GP: Copper deficiency myelopathy. J Neurol. 257:869–881. 2010. View Article : Google Scholar : PubMed/NCBI

Naismith RT, Shepherd JB, Weihl CC, Tutlam NT and Cross AH: Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol. 66:1025–1027. 2009. View Article : Google Scholar : PubMed/NCBI

Lombardo MF, Ciriolo MR, Rotilio G and Rossi L: Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells. Cell Mol Life Sci. 60:1733–1743. 2003. View Article : Google Scholar : PubMed/NCBI

Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, et al: Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration. Mol Biol Cell. 36:ar332025.PubMed/NCBI

Lutsenko S, Washington-Hughes C, Ralle M and Schmidt K: Copper and the brain noradrenergic system. J Biol Inorg Chem. 24:1179–1188. 2019. View Article : Google Scholar : PubMed/NCBI

Robertson D, Haile V, Perry SE, Robertson RM, Phillips JA III and Biaggioni I: Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 18:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

Bortolato M, Chen K and Shih JC: Monoamine oxidase inactivation: From pathophysiology to therapeutics. Adv Drug Deliv Rev. 60:1527–1533. 2008. View Article : Google Scholar : PubMed/NCBI

Xu Y, Zhang J, Wang H, Mao F, Bao K, Liu W, Zhu J, Li X, Zhang H and Li J: Rational design of novel selective dual-target inhibitors of acetylcholinesterase and monoamine oxidase B as potential anti-Alzheimer's disease agents. ACS Chem Neurosci. 10:482–496. 2019. View Article : Google Scholar

Kaler SG and Holmes CS: Catecholamine metabolites affected by the copper-dependent enzyme dopamine-beta-hydroxylase provide sensitive biomarkers for early diagnosis of menkes disease and viral-mediated ATP7A gene therapy. Adv Pharmacol. 68:223–233. 2013. View Article : Google Scholar : PubMed/NCBI

Rahman MK, Rahman F, Rahman T and Kato T: Dopamine-β-Hydroxylase (DBH), Its cofactors and other biochemical parameters in the serum of neurological patients in Bangladesh. Int J Biomed Sci. 5:395–401. 2009. View Article : Google Scholar : PubMed/NCBI

Xiao T, Ackerman CM, Carroll EC, Jia S, Hoagland A, Chan J, Thai B, Liu CS, Isacoff EY and Chang CJ: Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 14:655–663. 2018. View Article : Google Scholar : PubMed/NCBI

Bisaglia M and Bubacco L: Copper Ions and Parkinson's disease: Why is homeostasis so relevant? Biomolecules. 10:1952020. View Article : Google Scholar : PubMed/NCBI

Liu JL, Fan YG, Yang ZS, Wang ZY and Guo C: Iron and Alzheimer's disease: From pathogenesis to therapeutic implications. Front Neurosci. 12:6322018. View Article : Google Scholar : PubMed/NCBI

Mondola P, Damiano S, Sasso A and Santillo M: The Cu, Zn Superoxide Dismutase: Not only a dismutase enzyme. Front Physiol. 7:5942016. View Article : Google Scholar : PubMed/NCBI

Gu S, Xu M, Chen L, Shi X and Luo SZ: A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation. J Biol Chem. 299:1028572023. View Article : Google Scholar : PubMed/NCBI

Trist BG, Hilton JB, Hare DJ, Crouch PJ and Double KL: Superoxide dismutase 1 in health and disease: How a frontline antioxidant becomes neurotoxic. Angew Chem Int Ed Engl. 60:9215–9246. 2021. View Article : Google Scholar

Furukawa Y, Torres AS and O'Halloran TV: Oxygen-induced maturation of SOD1: A key role for disulfide formation by the copper chaperone CCS. EMBO J. 23:2872–2881. 2004. View Article : Google Scholar : PubMed/NCBI

Prohaska JR and Brokate B: Lower copper, zinc-superoxide dismutase protein but not mRNA in organs of copper-deficient rats. Arch Biochem Biophys. 393:170–176. 2001. View Article : Google Scholar : PubMed/NCBI

Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, et al: SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem. 286:44557–44568. 2011. View Article : Google Scholar : PubMed/NCBI

Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J and Gitlin JD: Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci USA. 97:2886–2891. 2000. View Article : Google Scholar : PubMed/NCBI

Fischer LR and Glass JD: Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures. Acta Neuropathol. 119:249–259. 2010. View Article : Google Scholar

Dusek P, Litwin T and Członkowska A: Neurologic impairment in Wilson disease. Ann Transl Med. 7(Suppl 2): S642019. View Article : Google Scholar : PubMed/NCBI

Dong Y, Shi SS, Chen S, Ni W, Zhu M and Wu ZY: The discrepancy between the absence of copper deposition and the presence of neuronal damage in the brain of Atp7b(-/-) mice. Metallomics. 7:283–288. 2015. View Article : Google Scholar : PubMed/NCBI

Fan H, Wang K, Zhao X, Song B, Yao T, Liu T, Gao G, Lu W and Liu C: Emerging insights into cuproptosis and copper metabolism: Implications for age-related diseases and potential therapeutic strategies. Front Aging Neurosci. 16:13351222024. View Article : Google Scholar : PubMed/NCBI

Gao L and Zhang A: Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations. Front Immunol. 14:12360632023. View Article : Google Scholar : PubMed/NCBI

Shields HJ, Traa A and Van Raamsdonk JM: Beneficial and detrimental effects of reactive oxygen species on lifespan: A comprehensive review of comparative and experimental studies. Front Cell Dev Biol. 9:6281572021. View Article : Google Scholar : PubMed/NCBI

Juan CA, Pérez de la Lastra JM, Plou FJ and Pérez-Lebeña E: The chemistry of reactive oxygen species (ROS) revisited: Outlining their role in biological macromolecules (DNA, Lipids and Proteins) and induced pathologies. Int J Mol Sci. 22:46422021. View Article : Google Scholar : PubMed/NCBI

Liu Z, Gan Y, Shen Z, Cai S, Wang X, Li Y, Li X, Fu H, Chen J and Li N: Role of copper homeostasis and cuproptosis in heart failure pathogenesis: Implications for therapeutic strategies. Front Pharmacol. 15:15279012024. View Article : Google Scholar

Yu Q, Xiao Y, Guan M, Zhang X, Yu J, Han M and Li Z: Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes. Front Mol Biosci. 11:14724922024. View Article : Google Scholar : PubMed/NCBI

Feng W, Su S, Song C, Yu F, Zhou J, Li J, Jia R, Xu P and Tang Y: Effects of copper exposure on oxidative stress, apoptosis, endoplasmic reticulum stress, autophagy and immune response in different tissues of Chinese mitten crab (Eriocheir sinensis). Antioxidants (Basel). 11:20292022. View Article : Google Scholar : PubMed/NCBI

Liu T, Sun L, Zhang Y, Wang Y and Zheng J: Imbalanced GSH/ROS and sequential cell death. J Biochem Mol Toxicol. 36:e229422022. View Article : Google Scholar

Medici V, Sarode GV, Napoli E, Song GY, Shibata NM, Guimarães AO, Mordaunt CE, Kieffer DA, Mazi TA, Czlonkowska A, et al: mtDNA depletion-like syndrome in Wilson disease. Liver Int. 40:2776–2787. 2020. View Article : Google Scholar : PubMed/NCBI

Cai Y, Xiao R, Zhang Y, Xu D, Wang N, Han M, Zhang Y, Zhang L and Zhou W: DHPA Protects SH-SY5Y Cells from oxidative stress-induced apoptosis via mitochondria apoptosis and the Keap1/Nrf2/HO-1 signaling pathway. Antioxidants (Basel). 11:17942022. View Article : Google Scholar : PubMed/NCBI

Lu J, Liu X, Li X, Li H, Shi L, Xia X, He BL, Meyer TF, Li X, Sun H and Yang X: Copper regulates the host innate immune response against bacterial infection via activation of ALPK1 kinase. Proc Natl Acad Sci USA. 121:e23116301212024. View Article : Google Scholar : PubMed/NCBI

Wang Y, Zhao H, Shao Y, Liu J, Li J and Xing M: Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken. Oncotarget. 8:98103–98116. 2017. View Article : Google Scholar : PubMed/NCBI

Deigendesch N, Zychlinsky A and Meissner F: Copper regulates the canonical NLRP3 inflammasome. J Immunol. 200:1607–1617. 2018. View Article : Google Scholar : PubMed/NCBI

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B and Wang G: Ferroptosis: Past, present and future. Cell Death Dis. 11:882020. View Article : Google Scholar : PubMed/NCBI

Ma T, Du J, Zhang Y, Wang Y, Wang B and Zhang T: GPX4-independent ferroptosis-a new strategy in disease's therapy. Cell Death Discov. 8:4342022. View Article : Google Scholar : PubMed/NCBI

Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ, Kroemer G, Chen X, Tang D and Liu J: Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 19:1982–1996. 2023. View Article : Google Scholar : PubMed/NCBI

Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K and Valko M: Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging. Arch Toxicol. 97:2499–2574. 2023. View Article : Google Scholar : PubMed/NCBI

Formigari A, Gregianin E and Irato P: The effect of zinc and the role of p53 in copper-induced cellular stress responses. J Appl Toxicol. 33:527–536. 2013. View Article : Google Scholar : PubMed/NCBI

Aschner M, Skalny AV, Lu R, Martins AC, Tizabi Y, Nekhoroshev SV, Santamaria A, Sinitskiy AI and Tinkov AA: Mitochondrial pathways of copper neurotoxicity: Focus on mitochondrial dynamics and mitophagy. Front Mol Neurosci. 17:15048022024. View Article : Google Scholar : PubMed/NCBI

Tassone G, Kola A, Valensin D and Pozzi C: dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer's disease. Life (Basel). 11:3862021.PubMed/NCBI

Tang D, Chen X and Kroemer G: Cuproptosis: A copper-triggered modality of mitochondrial cell death. Cell Res. 32:417–418. 2022. View Article : Google Scholar : PubMed/NCBI

Wang D, Tian Z, Zhang P, Zhen L, Meng Q, Sun B, Xu X, Jia T and Li S: The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease. Biomed Pharmacother. 163:1148302023. View Article : Google Scholar : PubMed/NCBI

Xiong C, Ling H, Hao Q and Zhou X: Cuproptosis: p53-regulated metabolic cell death? Cell Death Differ. 30:876–884. 2023. View Article : Google Scholar : PubMed/NCBI

Brand MD, Orr AL, Perevoshchikova IV and Quinlan CL: The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol. 169(Suppl 2): S1–S8. 2013. View Article : Google Scholar

Zulkifli M, Spelbring AN, Zhang Y, Soma S, Chen S, Li L, Le T, Shanbhag V, Petris MJ, Chen TY, et al: FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery. Proc Natl Acad Sci USA. 120:e22167221202023. View Article : Google Scholar : PubMed/NCBI

Kar S, Sen S, Maji S, Saraf D, Ruturaj, Paul R, Dutt S, Mondal B, Rodriguez-Boulan E, Schreiner R, et al: Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1. J Biol Chem. 298:1016312022. View Article : Google Scholar : PubMed/NCBI

An Y, Li S, Huang X, Chen X, Shan H and Zhang M: The role of copper homeostasis in brain disease. Int J Mol Sci. 23:138502022. View Article : Google Scholar : PubMed/NCBI

Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M and Shoubridge EA: Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. Hum Mol Genet. 13:1839–1848. 2004. View Article : Google Scholar : PubMed/NCBI

Boulet A, Vest KE, Maynard MK, Gammon MG, Russell AC, Mathews AT, Cole SE, Zhu X, Phillips CB, Kwong JQ, et al: The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 293:1887–1896. 2018. View Article : Google Scholar :

Robinson NJ and Winge DR: Copper metallochaperones. Annu Rev Biochem. 79:537–562. 2010. View Article : Google Scholar : PubMed/NCBI

Dela Cruz R, Jeong MY and Winge DR: Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis. Microb Cell. 3:275–284. 2016. View Article : Google Scholar

Garza NM, Swaminathan AB, Maremanda KP, Zulkifli M and Gohil VM: Mitochondrial copper in human genetic disorders. Trends Endocrinol Metab. 34:21–33. 2023. View Article : Google Scholar

Kawamata H and Manfredi G: Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane space. Antioxid Redox Signal. 13:1375–1384. 2010. View Article : Google Scholar : PubMed/NCBI

Boyd SD, Calvo JS, Liu L, Ullrich MS, Skopp A, Meloni G and Winkler DD: The yeast copper chaperone for copper-zinc superoxide dismutase (CCS1) is a multifunctional chaperone promoting all levels of SOD1 maturation. J Biol Chem. 294:1956–1966. 2019. View Article : Google Scholar :

Suzuki Y, Ali M, Fischer M and Riemer J: Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria. Nat Commun. 4:24302013. View Article : Google Scholar : PubMed/NCBI

Cong Y, Li N, Zhang Z, Shang Y and Zhao H: Cuproptosis: Molecular mechanisms, cancer prognosis, and therapeutic applications. J Transl Med. 23:1042025. View Article : Google Scholar : PubMed/NCBI

Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR and Tsvetkov P: FDX1 regulates cellular protein lipoylation through direct binding to LIAS. J Biol Chem. 299:1050462023. View Article : Google Scholar : PubMed/NCBI

Rowland EA, Snowden CK and Cristea IM: Protein lipoylation: An evolutionarily conserved metabolic regulator of health and disease. Curr Opin Chem Biol. 42:76–85. 2018. View Article : Google Scholar :

Springer C, Humayun D and Skouta R: Cuproptosis: Unraveling the mechanisms of copper-induced cell death and its implication in cancer therapy. Cancers (Basel). 16:6472024. View Article : Google Scholar : PubMed/NCBI

Lu B and Guo S: Mechanisms linking mitochondrial dysfunction and proteostasis failure. Trends Cell Biol. 30:317–328. 2020. View Article : Google Scholar : PubMed/NCBI

Vázquez G, Caballero AB, Kokinda J, Hijano A, Sabaté R and Gamez P: Copper, dityrosine cross-links and amyloid-β aggregation. J Biol Inorg Chem. 24:1217–1229. 2019. View Article : Google Scholar

Liu Y, Lu S, Wu Ll, Yang L, Yang L and Wang J: The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 14:5192023. View Article : Google Scholar : PubMed/NCBI

Wang J, Li J, Liu J, Chan KY, Lee HS, Lin KN, Wang CC and Lau TS: Interplay of ferroptosis and cuproptosis in cancer: Dissecting metal-driven mechanisms for therapeutic potentials. Cancers (Basel). 16:5122024. View Article : Google Scholar : PubMed/NCBI

Saporito-Magriñá CM, Musacco-Sebio RN, Andrieux G, Kook L, Orrego MT, Tuttolomondo MV, Desimone MF, Boerries M, Borner C and Repetto MG: Copper-induced cell death and the protective role of glutathione: The implication of impaired protein folding rather than oxidative stress. Metallomics. 10:1743–1754. 2018. View Article : Google Scholar : PubMed/NCBI

Ribas V, García-Ruiz C and Fernández-Checa JC: Glutathione and mitochondria. Front Pharmacol. 5:1512014. View Article : Google Scholar : PubMed/NCBI

Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barnham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, et al: Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. J Neurosci. 25:672–679. 2005. View Article : Google Scholar : PubMed/NCBI

Okita Y, Rcom-H'cheo-Gauthier AN, Goulding M, Chung RS, Faller P and Pountney DL: Metallothionein, copper and alpha-synuclein in alpha-synucleinopathies. Front Neurosci. 11:1142017. View Article : Google Scholar : PubMed/NCBI

Xu W, Xu Q, Cheng H and Tan X: The efficacy and pharmacological mechanism of Zn7MT3 to protect against Alzheimer's disease. Sci Rep. 7:137632017. View Article : Google Scholar

Rossi L, Lippe G, Marchese E, De Martino A, Mavelli I, Rotilio G and Ciriolo MR: Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats. Biometals. 11:207–212. 1998. View Article : Google Scholar : PubMed/NCBI

Exley C, House E, Polwart A and Esiri MM: Brain burdens of aluminum, iron, and copper and their relationships with amyloid-β pathology in 60 human brains. J Alzheimers Dis. 31:725–730. 2012. View Article : Google Scholar

Keskitalo S, Farkas M, Hanenberg M, Szodorai A, Kulic L, Semmler A, Weller M, Nitsch RM and Linnebank M: Reciprocal modulation of Aβ42 aggregation by copper and homocysteine. Front Aging Neurosci. 6:2372014. View Article : Google Scholar

Kirss S, Reinapu A, Kabin E, Smirnova J, Tõugu V and Palumaa P: α-Lipoic acid: A potential regulator of copper metabolism in Alzheimer's disease. Front Mol Biosci. 11:14515362024. View Article : Google Scholar

Kepp KP: Bioinorganic chemistry of Alzheimer's disease. Chem Rev. 112:5193–5239. 2012. View Article : Google Scholar : PubMed/NCBI

Li YQ, Tan SS, Wu D, Zhang Q, Wang T and Zheng G: The role of intracellular and extracellular copper compartmentalization in Alzheimer's disease pathology and its implications for diagnosis and therapy. Front Neurosci. 19:15530642025. View Article : Google Scholar : PubMed/NCBI

Brewer GJ: Alzheimer's disease causation by copper toxicity and treatment with zinc. Front Aging Neurosci. 6:922014. View Article : Google Scholar : PubMed/NCBI

Ventriglia M, Bucossi S, Panetta V and Squitti R: Copper in Alzheimer's disease: A meta-analysis of serum, plasma, and cerebrospinal fluid studies. J Alzheimers Dis. 30:981–984. 2012. View Article : Google Scholar : PubMed/NCBI

Squitti R, Pasqualetti P, Dal Forno G, Moffa F, Cassetta E, Lupoi D, Vernieri F, Rossi L, Baldassini M and Rossini PM: Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology. 64:1040–1046. 2005. View Article : Google Scholar : PubMed/NCBI

Zhu MJ, Zhang L and Wang CP: Copper overload promotes β-amyloid induced NLRP3/Caspase-1/GSDMD-mediated pyroptosis in Alzheimer's disease. J Integr Neurosci. 23:1942024. View Article : Google Scholar

Selkoe DJ and Hardy J: The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 8:595–608. 2016. View Article : Google Scholar : PubMed/NCBI

Santoro A, Grimaldi M, Buonocore M, Stillitano I and D'Ursi AM: Exploring the early stages of the amyloid Aβ(1-42) peptide aggregation process: An NMR study. Pharmaceuticals (Basel). 14:7322021. View Article : Google Scholar

Sgourakis NG, Yan Y, McCallum SA, Wang C and Garcia AE: The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: A combined MD/NMR study. J Mol Biol. 368:1448–1457. 2007. View Article : Google Scholar : PubMed/NCBI

Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, et al: The amyloid-β pathway in Alzheimer's disease. Mol Psychiatry. 26:5481–5503. 2021. View Article : Google Scholar : PubMed/NCBI

Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, et al: α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease. Proc Natl Acad Sci USA. 116:8895–8900. 2019. View Article : Google Scholar

Abelein A, Ciofi-Baffoni S, Mörman C, Kumar R, Giachetti A, Piccioli M and Biverstål H: Molecular structure of Cu(II)-Bound Amyloid-β monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease. JACS Au. 2:2571–2584. 2022. View Article : Google Scholar : PubMed/NCBI

Brewer GJ: Divalent copper as a major triggering agent in Alzheimer's disease. J Alzheimers Dis. 46:593–604. 2015. View Article : Google Scholar : PubMed/NCBI

Li DD, Zhang W, Wang ZY and Zhao P: Serum copper, zinc, and iron levels in patients with Alzheimer's disease: A meta-analysis of case-control studies. Front Aging Neurosci. 9:3002017. View Article : Google Scholar : PubMed/NCBI

Faller P and Hureau C: Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide. Dalton Trans. 7:1080–1094. 2009. View Article : Google Scholar

Posadas Y, Sánchez-López C and Quintanar L: Copper binding and protein aggregation: A journey from the brain to the human lens. RSC Chem Biol. 4:974–985. 2023. View Article : Google Scholar : PubMed/NCBI

Sasanian N, Bernson D, Horvath I, Wittung-Stafshede P and Esbjörner EK: Redox-dependent copper ion modulation of amyloid-β (1-42) aggregation in vitro. Biomolecules. 10:9242020. View Article : Google Scholar

Jiang D, Zhang L, Grant GPG, Dudzik CG, Chen S, Patel S, Hao Y, Millhauser GL and Zhou F: The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: A pathway to accumulation of copper in senile plaques. Biochemistry. 52:547–556. 2013. View Article : Google Scholar

Wu D, Zhang W, Luo Q, Luo K, Huang L, Wang W, Huang T, Chen R, Lin Y, Pang D and Xiao G: Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment. J Cell Biochem. 111:627–633. 2010. View Article : Google Scholar : PubMed/NCBI

García S, Cuscó C, Brissos RF, Torrents E, Caubet A and Gamez P: Dual role of Cu²⁺ ions on the aggregation and degradation of soluble Aβ oligomers and protofibrils investigated by fluorescence spectroscopy and AFM. J Inorg Biochem. 116:26–36. 2012. View Article : Google Scholar

Hong W, Hu C, Wang C, Zhu B, Tian M and Qin H: Effects of amyloid β (Aβ)42 and Gasdermin D on the progression of Alzheimer's disease in vitro and in vivo through the regulation of astrocyte pyroptosis. Aging (Albany NY). 15:12209–12224. 2023. View Article : Google Scholar : PubMed/NCBI

Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, et al: Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proc Natl Acad Sci USA. 110:14771–14776. 2013. View Article : Google Scholar

Hane F, Tran G, Attwood SJ and Leonenko Z: Cu(2+) affects amyloid-beta (1-42) aggregation by increasing peptide-peptide binding forces. PLoS One. 8:e590052013. View Article : Google Scholar

Maghsoodi F, Martin TD and Chi EY: Partial destabilization of amyloid-β protofibril by methionine photo-oxidation: A molecular dynamic simulation study. ACS Omega. 8:10148–10159. 2023. View Article : Google Scholar : PubMed/NCBI

Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH and Makpol S: Evaluation of the expression of amyloid precursor protein and the ratio of secreted amyloid beta 42 to amyloid beta 40 in SH-SY5Y cells stably transfected with wild-type, single-mutant and double-mutant forms of the APP gene for the study of Alzheimer's disease pathology. Appl Biochem Biotechnol. 183:853–866. 2017. View Article : Google Scholar : PubMed/NCBI

Zubcic K, Hof PR, Simic G and Jazvinscak Jembrek M: The role of copper in Tau-related pathology in Alzheimer's disease. Front Mol Neurosci. 13:5723082020. View Article : Google Scholar : PubMed/NCBI

Larry Sparks D: Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain. J Mol Neurosci. 24:97–104. 2004. View Article : Google Scholar : PubMed/NCBI

Iqbal K, Liu F and Gong CX: Tau and neurodegenerative disease: The story so far. Nat Rev Neurol. 12:15–27. 2016. View Article : Google Scholar

Alonso AD, Cohen LS, Corbo C, Morozova V, ElIdrissi A, Phillips G and Kleiman FE: Hyperphosphorylation of Tau associates with changes in its function beyond microtubule stability. Front Cell Neurosci. 12:3382018. View Article : Google Scholar : PubMed/NCBI

Medeiros R, Baglietto-Vargas D and LaFerla FM: The role of tau in Alzheimer's disease and related disorders. CNS Neurosci Ther. 17:514–524. 2011. View Article : Google Scholar

Zwang TJ, Sastre ED, Wolf N, Ruiz-Uribe N, Woost B, Hoglund Z, Fan Z, Bailey J, Nfor L, Buée L, et al: Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology. Cell Rep. 43:1145742024. View Article : Google Scholar : PubMed/NCBI

Zhou LX, Du JT, Zeng ZY, Wu WH, Zhao YF, Kanazawa K, Ishizuka Y, Nemoto T, Nakanishi H and Li YM: Copper (II) modulates in vitro aggregation of a tau peptide. Peptides. 28:2229–2234. 2007. View Article : Google Scholar : PubMed/NCBI

Jin N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X and Liu F: Truncation and activation of GSK-3β by calpain I: A molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Sci Rep. 5:81872015. View Article : Google Scholar

Crnich E, Lullo R, Tabaka A, Havens MA and Kissel DS: Interactions of copper and copper chelate compounds with the amyloid beta peptide: An investigation into electrochemistry, reactive oxygen species and peptide aggregation. J Inorg Biochem. 222:1114932021. View Article : Google Scholar : PubMed/NCBI

Bush AI and Tanzi RE: Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics. 5:421–432. 2008. View Article : Google Scholar : PubMed/NCBI

Jin M, Shepardson N, Yang T, Chen G, Walsh D and Selkoe DJ: Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci USA. 108:5819–5824. 2011. View Article : Google Scholar : PubMed/NCBI

Huang X: A concise review on oxidative stress-mediated ferroptosis and cuproptosis in Alzheimer's disease. Cells. 12:13692023. View Article : Google Scholar : PubMed/NCBI

Xing L, Wang Z, Hao Z, Pan P, Yang A and Wang J: Cuproptosis in stroke: Focusing on pathogenesis and treatment. Front Mol Neurosci. 17:13491232024. View Article : Google Scholar : PubMed/NCBI

Hu R, Xiao Z, Qiao M, Liu C, Wu G, Wang Y, Dong M and Huang Z: Construction and validation of a bioinformatics-based screen for cuproptosis-related genes and risk model for Alzheimer's disease. Mol Med Rep. 30:1942024. View Article : Google Scholar

Chen G, Xi E, Gu X, Wang H and Tang Q: The study on cuproptosis in Alzheimer's disease based on the cuproptosis key gene FDX1. Front Aging Neurosci. 16:14803322024. View Article : Google Scholar

Jia F, Han W, Gao S, Huang J, Zhao W, Lu Z, Zhao W, Li Z, Wang Z and Guo Y: Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer's disease. Front Mol Biosci. 11:14786112024. View Article : Google Scholar : PubMed/NCBI

Ma MM, Zhao J, Liu L and Wu CY: Identification of cuproptosis-related genes in Alzheimer's disease based on bioinformatic analysis. Eur J Med Res. 29:4952024. View Article : Google Scholar : PubMed/NCBI

Chen Y, Nan Y, Xu L, Dai A, Orteg RMM, Ma M, Zeng Y and Li J: Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis. Part Fibre Toxicol. 22:132025. View Article : Google Scholar : PubMed/NCBI

Gromadzka G, Tarnacka B, Flaga A and Adamczyk A: Copper dyshomeostasis in neurodegenerative diseases-therapeutic implications. Int J Mol Sci. 21:92592020. View Article : Google Scholar : PubMed/NCBI

Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF and Scott JD: Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron. 40:595–607. 2003. View Article : Google Scholar : PubMed/NCBI

Magrì A, Tomasello B, Naletova I, Tabbì G, Cairns WRL, Greco V, Sciuto S, La Mendola D and Rizzarelli E: New BDNF and NT-3 cyclic mimetics concur with copper to activate trophic signaling pathways as potential molecular entities to protect old brains from neurodegeneration. Biomolecules. 14:11042024. View Article : Google Scholar : PubMed/NCBI

Chen L, Min J and Wang F: Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther. 7:3782022. View Article : Google Scholar : PubMed/NCBI

Xu J, Church SJ, Patassini S, Begley P, Waldvogel HJ, Curtis MA, Faull RLM, Unwin RD and Cooper GJS: Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia. Metallomics. 9:1106–1119. 2017. View Article : Google Scholar : PubMed/NCBI

Schrag M, Mueller C, Oyoyo U, Smith MA and Kirsch WM: Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion. Prog Neurobiol. 94:296–306. 2011. View Article : Google Scholar : PubMed/NCBI

Cilliers K: Trace element alterations in Alzheimer's disease: A review. Clin Anat. 34:766–773. 2021. View Article : Google Scholar : PubMed/NCBI

Deibel MA, Ehmann WD and Markesbery WR: Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress. J Neurol Sci. 143:137–142. 1996. View Article : Google Scholar : PubMed/NCBI

Bucossi S, Ventriglia M, Panetta V, Salustri C, Pasqualetti P, Mariani S, Siotto M, Rossini PM and Squitti R: Copper in Alzheimer's disease: A meta-analysis of serum,plasma, and cerebrospinal fluid studies. J Alzheimers Dis. 24:175–185. 2011. View Article : Google Scholar

Loef M and Walach H: Copper and iron in Alzheimer's disease: A systematic review and its dietary implications. Br J Nutr. 107:7–19. 2012. View Article : Google Scholar

Sensi SL, Granzotto A, Siotto M and Squitti R: Copper and zinc dysregulation in Alzheimer's disease. Trends Pharmacol Sci. 39:1049–1063. 2018. View Article : Google Scholar : PubMed/NCBI

Bai R, Guo J, Ye XY, Xie Y and Xie T: Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease. Ageing Res Rev. 77:1016192022. View Article : Google Scholar : PubMed/NCBI

Squitti R, Ventriglia M, Simonelli I, Bonvicini C, Costa A, Perini G, Binetti G, Benussi L, Ghidoni R, Koch G, et al: Copper imbalance in Alzheimer's disease: Meta-analysis of serum, plasma, and brain specimens, and replication study evaluating ATP7B gene variants. Biomolecules. 11:9602021. View Article : Google Scholar : PubMed/NCBI

Yang SJ, Keen CL, Lanoue L, Rucker RB and Uriu-Adams JY: Low nitric oxide: A key factor underlying copper-deficiency teratogenicity. Free Radic Biol Med. 43:1639–1648. 2007. View Article : Google Scholar : PubMed/NCBI

Hureau C: Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview. Coord Chem Rev. 256:2164–2174. 2012. View Article : Google Scholar

Szabo ST, Harry GJ, Hayden KM, Szabo DT and Birnbaum L: Comparison of metal levels between postmortem brain and ventricular fluid in Alzheimer's disease and nondemented elderly controls. Toxicol Sci. 150:292–300. 2016. View Article : Google Scholar : PubMed/NCBI

Zhang Y, Chen H, Li R, Sterling K and Song W: Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future. Signal Transduct Target Ther. 8:2482023. View Article : Google Scholar

Song IS, Chen HH, Aiba I, Hossain A, Liang ZD, Klomp LW and Kuo MT: Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells. Mol Pharmacol. 74:705–713. 2008. View Article : Google Scholar : PubMed/NCBI

Bayer TA, Schäfer S, Simons A, Kemmling A, Kamer T, Tepests R, Eckert A, Schüssel K, Eikenberg O, Sturchler-Pierrat C, et al: Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice. Proc Natl Acad Sci USA. 100:14187–14192. 2003. View Article : Google Scholar

Schäfer S, Pajonk FG, Multhaup G and Bayer TA: Copper and clioquinol treatment in young APP transgenic and wild-type mice: Effects on life expectancy, body weight, and metal-ion levels. J Mol Med (Berl). 85:405–413. 2007. View Article : Google Scholar : PubMed/NCBI

Acevedo KM, Hung YH, Dalziel AH, Li Q-X, Laughton K, Wikhe K, Rembach A, Roberts B, Masters CL, Bush AI and Camakaris J: Copper promotes the trafficking of the amyloid precursor protein. J Biol Chem. 286:8252–8262. 2011. View Article : Google Scholar :

Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, et al: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease. Cell Death Differ. 28:1548–1562. 2021. View Article : Google Scholar : PubMed/NCBI

Soni P, Ammal Kaidery N, Sharma SM, Gazaryan I, Nikulin SV, Hushpulian DM and Thomas B: A critical appraisal of ferroptosis in Alzheimer's and Parkinson's disease: New insights into emerging mechanisms and therapeutic targets. Front Pharmacol. 15:13907982024. View Article : Google Scholar : PubMed/NCBI

Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, et al: Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30:665–676. 2001. View Article : Google Scholar : PubMed/NCBI

Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo J, Harrison J, Lannfelt L, Blennow K, Zetterberg H, et al: PBT2 rapidly improves cognition in Alzheimer's disease: Additional phase II analyses. J Alzheimers Dis. 20:509–516. 2010. View Article : Google Scholar : PubMed/NCBI

Lannfelt L, Blennow K, Zetterberg H, Batsman S, Ames D, Harrison J, Masters CL, Targum S, Bush AI, Murdoch R, et al: Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 7:779–786. 2008. View Article : Google Scholar : PubMed/NCBI

Wang T, Wang CY, Shan ZY, Teng WP and Wang ZY: Clioquinol reduces zinc accumulation in neuritic plaques and inhibits the amyloidogenic pathway in AβPP/PS1 transgenic mouse brain. J Alzheimers Dis. 29:549–559. 2012. View Article : Google Scholar

Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA and Lindquist S: Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci USA. 111:4013–4018. 2014. View Article : Google Scholar

Li X, Chen X and Gao X: Copper and cuproptosis: New therapeutic approaches for Alzheimer's disease. Front Aging Neurosci. 15:13004052023. View Article : Google Scholar

Greenberg BD, Carrillo MC, Ryan JM, Gold M, Gallagher K, Grundman M, Berman RM, Ashwood T and Siemers ER: Improving Alzheimer's disease phase II clinical trials. Alzheimers Dement. 9:39–49. 2013. View Article : Google Scholar

Villemagne VL, Rowe CC, Barnham KJ, Cherny R, Woodward M, Bozinosvski S, Salvado O, Bourgeat P, Perez K, Fowler C, et al: A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study. Alzheimers Dement (NY). 3:622–635. 2017. View Article : Google Scholar

Squitti R and Polimanti R: Copper phenotype in Alzheimer's disease: Dissecting the pathway. Am J Neurodegener Dis. 2:46–56. 2013.PubMed/NCBI

Drew SC: The case for abandoning therapeutic chelation of copper ions in Alzheimer's disease. Front Neurosci. 11:3172017. View Article : Google Scholar : PubMed/NCBI

Singh SK, Balendra V, Obaid AA, Esposto J, Tikhonova MA, Gautam NK and Poeggeler B: Copper-mediated β-amyloid toxicity and its chelation therapy in Alzheimer's disease. Metallomics. 14:mfac0182022. View Article : Google Scholar

Huang Q, Jiang C, Xia X, Wang Y, Yan C, Wang X, Lei T, Yang X, Yang W, Cheng G and Gao H: Pathological BBB crossing melanin-like nanoparticles as metal-ion chelators and neuroinflammation regulators against Alzheimer's disease. Research (Wash DC). 6:01802023.

Kang H, Han M, Xue J, Baek Y, Chang J, Hu S, Nam H, Jo MJ, El Fakhri G, Hutchens MP, et al: Renal clearable nanochelators for iron overload therapy. Nat Commun. 10:51342019. View Article : Google Scholar : PubMed/NCBI

Dodani SC, Firl A, Chan J, Nam CI, Aron AT, Onak CS, Ramos-Torres KM, Paek J, Webster CM, Feller MB and Chang CJ: Copper is an endogenous modulator of neural circuit spontaneous activity. Proc Natl Acad Sci USA. 111:16280–16285. 2014. View Article : Google Scholar : PubMed/NCBI

Schlief ML, Craig AM and Gitlin JD: NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci. 25:239–246. 2005. View Article : Google Scholar : PubMed/NCBI

Kong GK, Miles LA, Crespi GA, Morton CJ, Ng HL, Barnham KJ, McKinstry WJ, Cappai R and Parker MW: Copper binding to the Alzheimer's disease amyloid precursor protein. Eur Biophys J. 37:269–279. 2008. View Article : Google Scholar

Milton B, Farrell PJ, Birkett N and Krewski D: Modeling U-Shaped exposure-response relationships for agents that demonstrate toxicity due to both excess and deficiency. Risk Anal. 37:265–279. 2017. View Article : Google Scholar

Wu Z, Song X, Wang G and Wang B: U-shaped nonlinear relationship between dietary copper intake and peripheral neuropathy. Sci Rep. 14:252632024. View Article : Google Scholar : PubMed/NCBI

Chambers A, Krewski D, Birkett N, Plunkett L, Hertzberg R, Danzeisen R, Aggett PJ, Starr TB, Baker S, Dourson M, et al: An exposure-response curve for copper excess and deficiency. J Toxicol Environ Health B Crit Rev. 13:546–578. 2010. View Article : Google Scholar : PubMed/NCBI

Stern BR, Solioz M, Krewski D, Aggett P, Aw TC, Baker S, Crump K, Dourson M, Haber L, Hertzberg R, et al: Copper and human health: Biochemistry, genetics, and strategies for modeling dose-response relationships. J Toxicol Environ Health B Crit Rev. 10:157–222. 2007. View Article : Google Scholar : PubMed/NCBI

Yang S, Li Y, Zhou L, Wang X, Liu L and Wu M: Copper homeostasis and cuproptosis in atherosclerosis: Metabolism, mechanisms and potential therapeutic strategies. Cell Death Discov. 10:252024. View Article : Google Scholar : PubMed/NCBI

Opazo CM, Greenough MA and Bush AI: Copper: From neurotransmission to neuroproteostasis. Front Aging Neurosci. 6:1432014. View Article : Google Scholar : PubMed/NCBI

Sun B, Ding P, Song Y, Zhou J, Chen X, Peng C and Liu S: FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production. Redox Biol. 75:1033022024. View Article : Google Scholar : PubMed/NCBI

Yang S, Li X, Yan J, Jiang F, Fan X, Jin J, Zhang W, Zhong D and Li G: Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury. Sci Rep. 14:151752024. View Article : Google Scholar : PubMed/NCBI

Nie D, Chen C, Li Y and Zeng C: Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis. Blood Sci. 4:152–154. 2022. View Article : Google Scholar : PubMed/NCBI

Joshi PR, Sadre S, Guo XA, McCoy JG and Mootha VK: Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. J Biol Chem. 299:1050752023. View Article : Google Scholar : PubMed/NCBI

Kabin E, Dong Y, Roy S, Smirnova J, Smith JW, Ralle M, Summers K, Yang H, Dev S, Wang Y, et al: α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance. Proc Natl Acad Sci USA. 120:e23059611202023. View Article : Google Scholar

Dieter F, Esselun C and Eckert GP: Redox active α-Lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. Int J Mol Sci. 23:91862022. View Article : Google Scholar

Lai Y, Lin C, Lin X, Wu L, Zhao Y and Lin F: Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease. Front Aging Neurosci. 14:9326762022. View Article : Google Scholar : PubMed/NCBI

Zeng Y, Qian S, Cao Y and Xiao W: Unravelling the complex interplay of cuproptosis, lncRNAs, and immune infiltration in Alzheimer's disease: A step towards novel therapeutic targets. Ann Hum Biol. 51:23425312024. View Article : Google Scholar : PubMed/NCBI

Stremmel W: Bis-choline tetrathiomolybdate as old drug in a new design for Wilson's disease: Good for brain and liver? Hepatology. 69:901–903. 2019. View Article : Google Scholar

Choi BS and Zheng W: Copper transport to the brain by the blood-brain barrier and blood-CSF barrier. Brain Res. 1248:14–21. 2009. View Article : Google Scholar :

Borchard S, Raschke S, Zak KM, Eberhagen C, Einer C, Weber E, Müller SM, Michalke B, Lichtmannegger J, Wieser A, et al: Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage. Life Sci Alliance. 5:e2021011642021. View Article : Google Scholar : PubMed/NCBI

Liu L, He H, Du B and He Y: Nanoscale drug formulations for the treatment of Alzheimer's disease progression. RSC Adv. 15:4031–4078. 2025. View Article : Google Scholar : PubMed/NCBI

Kim Y, Park JH, Lee H and Nam JM: How do the size, charge and shape of nanoparticles affect amyloid β aggregation on brain lipid bilayer? Sci Rep. 6:195482016. View Article : Google Scholar

Zhu Y, Tang Y, Huang L, Nguyen M, Liu Y, Robert A and Meunier B: The specific copper(II) Chelator TDMQ20 is efficient for the treatment of Wilson's disease in mice. Pharmaceutics. 15:27192023. View Article : Google Scholar : PubMed/NCBI

Shi P, Li M, Ren J and Qu X: Gold nanocage-based dual responsive 'caged metal chelator' release system: Noninvasive remote control with near infrared for potential treatment of Alzheimer's disease. Adv Funct Mater. 23:5412–5419. 2013. View Article : Google Scholar

Andreozzi EM, Torres JB, Sunassee K, Dunn J, Walker-Samuel S, Szanda I and Blower PJ: Studies of copper trafficking in a mouse model of Alzheimer's disease by positron emission tomography: comparison of 64Cu acetate and 64CuGTSM. Metallomics. 9:1622–1633. 2017. View Article : Google Scholar : PubMed/NCBI

Hartard C, Weisner B, Dieu C and Kunze K: Wilson's disease with cerebral manifestation: Monitoring therapy by CSF copper concentration. J Neurol. 241:101–107. 1993. View Article : Google Scholar : PubMed/NCBI

Torres JB, Andreozzi EM, Dunn JT, Siddique M, Szanda I, Howlett DR, Sunassee K and Blower PJ: PET imaging of copper trafficking in a mouse model of Alzheimer disease. J Nucl Med. 57:109–114. 2016. View Article : Google Scholar

Peng F, Xie F and Muzik O: Alteration of copper fluxes in brain aging: A longitudinal study in rodent using (64)CuCl(2)-PET/CT. Aging Dis. 9:109–118. 2018. View Article : Google Scholar : PubMed/NCBI

Mohr I and Weiss KH: Biochemical markers for the diagnosis and monitoring of Wilson disease. Clin Biochem Rev. 40:59–77. 2019. View Article : Google Scholar : PubMed/NCBI

Zheng Z, White C, Lee J, Peterson TS, Bush AI, Sun GY, Weisman GA and Petris MJ: Altered microglial copper homeostasis in a mouse model of Alzheimer's disease. J Neurochem. 114:1630–1638. 2010. View Article : Google Scholar : PubMed/NCBI

Pyun J, McInnes LE, Donnelly PS, Mawal C, Bush AI, Short JL and Nicolazzo JA: Copper bis(thiosemicarbazone) complexes modulate P-glycoprotein expression and function in human brain microvascular endothelial cells. J Neurochem. 162:226–244. 2022. View Article : Google Scholar : PubMed/NCBI

Erratum to: Flavonoids as an intervention for Alzheimer's disease: Progress and hurdles towards defining a mechanism of action. Brain Plast. 9:972024. View Article : Google Scholar : PubMed/NCBI