Open Access

New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review)

  • Authors:
    • Daihan Xie
    • Lixin Xie
    • Chao Fang
    • Zhefei Du
    • Zhenyu Cao
    • Chunxia Su
    • Yu Huo
  • View Affiliations

  • Published online on: August 28, 2025     https://doi.org/10.3892/ijmm.2025.5617
  • Article Number: 176
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Despite the significant progress that has been made in the diagnosis and treatment of digestive system diseases, these conditions continue to pose a serious public health concern worldwide. There is an ongoing need for strategies that are precise, efficient and minimally invasive. Nanozymes, engineered nanomaterials that exhibit catalytic functions, have attracted considerable interest in this context. However, clinical application of nanozymes remains limited primarily due to their diversity, targetability, biocompatibility and early‑stage clinical translation. The present review presented a comprehensive analysis of nanozymes in digestive system diseases. The main enzyme‑like activities of nanozymes are summarized to guide further material selection and characteristic exploration. Preclinical applications are highlighted with mechanisms and theranostic effects discussed alongside their potential limitations. Emerging combination therapies, including photodynamic therapy, sonodynamic therapy and biotherapy, are reviewed. Finally, the current challenges of nanozymes and possible future developments are discussed.
View Figures
View References

Related Articles

Journal Cover

November-2025
Volume 56 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xie D, Xie L, Fang C, Du Z, Cao Z, Su C and Huo Y: New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review). Int J Mol Med 56: 176, 2025.
APA
Xie, D., Xie, L., Fang, C., Du, Z., Cao, Z., Su, C., & Huo, Y. (2025). New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review). International Journal of Molecular Medicine, 56, 176. https://doi.org/10.3892/ijmm.2025.5617
MLA
Xie, D., Xie, L., Fang, C., Du, Z., Cao, Z., Su, C., Huo, Y."New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review)". International Journal of Molecular Medicine 56.5 (2025): 176.
Chicago
Xie, D., Xie, L., Fang, C., Du, Z., Cao, Z., Su, C., Huo, Y."New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review)". International Journal of Molecular Medicine 56, no. 5 (2025): 176. https://doi.org/10.3892/ijmm.2025.5617