Open Access

Innovative strategies to enhance MSCs efficacy in acute kidney injury (Review)

  • Authors:
    • Yuanxia Zou
    • Jian Dai
    • Jingyuan Fu
    • Honglian Wang
    • Meng Yang
    • Jiraporn Kantapan
    • Li Wang
    • Nathupakorn Dechsupa
  • View Affiliations

  • Published online on: September 1, 2025     https://doi.org/10.3892/ijmm.2025.5620
  • Article Number: 179
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute kidney injury (AKI) remains a significant clinical challenge, characterized by rapid kidney dysfunction with potential progression to chronic kidney disease. Mesenchymal stem cells (MSCs) offer promising therapeutic potential due to their regenerative, immunomodulatory and anti‑inflammatory capabilities. Despite these advantages, clinical translation is hampered by low MSCs retention, limited cell survival and suboptimal secretion of therapeutic factors in injured renal tissues. Recent research efforts have introduced innovative strategies to optimize MSCs effectiveness, including various preconditioning approaches (hypoxia, chemical/drug‑based and biological cytokines), advanced three‑dimensional cell culture methods (hydrogels and spheroids), genetic modification techniques and improved delivery routes. The present review summarizes current advancements, underlying mechanisms and therapeutic outcomes associated with these novel strategies to enhance MSCs efficacy in AKI, highlighting their clinical potential and guiding future translational research directions.
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November-2025
Volume 56 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zou Y, Dai J, Fu J, Wang H, Yang M, Kantapan J, Wang L and Dechsupa N: Innovative strategies to enhance MSCs efficacy in acute kidney injury (Review). Int J Mol Med 56: 179, 2025.
APA
Zou, Y., Dai, J., Fu, J., Wang, H., Yang, M., Kantapan, J. ... Dechsupa, N. (2025). Innovative strategies to enhance MSCs efficacy in acute kidney injury (Review). International Journal of Molecular Medicine, 56, 179. https://doi.org/10.3892/ijmm.2025.5620
MLA
Zou, Y., Dai, J., Fu, J., Wang, H., Yang, M., Kantapan, J., Wang, L., Dechsupa, N."Innovative strategies to enhance MSCs efficacy in acute kidney injury (Review)". International Journal of Molecular Medicine 56.5 (2025): 179.
Chicago
Zou, Y., Dai, J., Fu, J., Wang, H., Yang, M., Kantapan, J., Wang, L., Dechsupa, N."Innovative strategies to enhance MSCs efficacy in acute kidney injury (Review)". International Journal of Molecular Medicine 56, no. 5 (2025): 179. https://doi.org/10.3892/ijmm.2025.5620