Open Access

Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review)

  • Authors:
    • Junwei Gao
    • Lingyao Li
    • Siqi Zhai
    • Yan Dong
    • Zhiyi Zhang
    • Duomao Lin
    • Jun Ma
  • View Affiliations

  • Published online on: September 10, 2025     https://doi.org/10.3892/ijmm.2025.5632
  • Article Number: 191
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myocardial ischemia reperfusion injury (MIRI) remains a key and difficult issue in the field of cardiovascular diseases, and its pathogenesis involves multiple aspects. Exercise can effectively improve MIRI, and the mechanisms include reducing oxidative stress and inflammatory responses, regulating mitochondrial function and metabolic abnormalities, and so on. For patients undergoing reperfusion, rehabilitation therapy mainly based on exercise has important clinical significance. The present study expounded on the occurrence of MIRI from the perspective of mechanisms and the improvement effect of exercise on MIRI, elaborates on the main current exercise strategies and existing problems from the aspect of clinical practice, and discusses the possible future development directions.
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November-2025
Volume 56 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Gao J, Li L, Zhai S, Dong Y, Zhang Z, Lin D and Ma J: Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review). Int J Mol Med 56: 191, 2025.
APA
Gao, J., Li, L., Zhai, S., Dong, Y., Zhang, Z., Lin, D., & Ma, J. (2025). Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review). International Journal of Molecular Medicine, 56, 191. https://doi.org/10.3892/ijmm.2025.5632
MLA
Gao, J., Li, L., Zhai, S., Dong, Y., Zhang, Z., Lin, D., Ma, J."Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review)". International Journal of Molecular Medicine 56.5 (2025): 191.
Chicago
Gao, J., Li, L., Zhai, S., Dong, Y., Zhang, Z., Lin, D., Ma, J."Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review)". International Journal of Molecular Medicine 56, no. 5 (2025): 191. https://doi.org/10.3892/ijmm.2025.5632