Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series
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- Published online on: September 10, 2025 https://doi.org/10.3892/mco.2025.2893
- Article Number: 98
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Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial parts, which makes it easy to misdiagnose malignancies on pre‑surgery examinations. Therefore, clinical and pathological features of SPAF at the Second Affiliated Hospital Zhejiang University School of Medicine (Hangzhou, China) were summarized in the present study to assist clinical practice. A total of 13 cases encountered at our hospital were collected and immunohistochemistry (IHC) staining was performed on their specimens. SPAF appears as a unilocular cystic mass on imaging. Serum estradiol and prolactin levels were elevated in certain patients. The IHC staining of SPAF was estrogen receptor‑, progesterone receptor‑ and human epidermal growth factor receptor 2‑positive but Ki‑67‑ and p53‑negative. The present study proved the sex hormone sensitivity of SPAF and the benign prognosis of patients. Magnetic resonance imaging is a promising method for differential diagnosis before surgery.
