Open Access

Oral microbiota: Roles and treatment in radiation injury (Review)

  • Authors:
    • Jiaqin Song
    • Lei Xia
  • View Affiliations

  • Published online on: August 8, 2025     https://doi.org/10.3892/ol.2025.15218
  • Article Number: 472
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

While radiotherapy for malignant tumors increases the rate of local control for patients, it also inevitably causes damage to the surrounding normal tissues, resulting in different types and degrees of radiation injury (RI). RI has a significant negative impact on quality of life. However, there is no viable method for preventing and treating these complications. The oral microbiota plays a key role in the development of numerous categories of RI, such as radiation‑induced brain injury, radiation‑induced oral injury and radiation‑induced lung injury. The aim of the present review is to clarify the potential mechanisms of RI and provide a comprehensive overview of the association between 10 distinct categories of RI and oral microbiota, thereby shedding light on novel clinical approaches for the prevention and treatment of RI based on modulating oral microbiota. This may open new avenues for targeted interventions.
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October-2025
Volume 30 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Song J and Xia L: Oral microbiota: Roles and treatment in radiation injury (Review). Oncol Lett 30: 472, 2025.
APA
Song, J., & Xia, L. (2025). Oral microbiota: Roles and treatment in radiation injury (Review). Oncology Letters, 30, 472. https://doi.org/10.3892/ol.2025.15218
MLA
Song, J., Xia, L."Oral microbiota: Roles and treatment in radiation injury (Review)". Oncology Letters 30.4 (2025): 472.
Chicago
Song, J., Xia, L."Oral microbiota: Roles and treatment in radiation injury (Review)". Oncology Letters 30, no. 4 (2025): 472. https://doi.org/10.3892/ol.2025.15218