Open Access

Emerging dual role of ferroptosis in lung cancer (Review)

  • Authors:
    • Anqi Wu
    • Yingchen Ni
    • Youlang Zhou
    • Jiahai Shi
  • View Affiliations

  • Published online on: August 21, 2025     https://doi.org/10.3892/or.2025.8974
  • Article Number: 141
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung cancer (LC) is the second most frequently diagnosed malignancy worldwide and has the highest mortality rate among all types of cancer. Despite advancements in treatment strategies, the overall survival rate for affected individuals remains low. Ferroptosis, a form of regulated cell death characterized by iron‑dependent lipid peroxidation and accumulation of reactive oxygen species, serves a role in LC. The present review aimed to explore the dual role of ferroptosis in LC, examining both its pathological and therapeutic implications. Ferroptosis contributes to tumor progression, modulates the immune microenvironment and influences treatment resistance. Conversely, it also enhances the efficacy of immunotherapy, increases radiosensitivity and decreases chemotherapy resistance. The present study aimed to summarize the potential of ferroptosis‑based strategies, including the use of nanomaterials and combination therapy, to inform future research and therapeutic approaches.
View Figures
View References

Related Articles

Journal Cover

November-2025
Volume 54 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wu A, Ni Y, Zhou Y and Shi J: Emerging dual role of ferroptosis in lung cancer (Review). Oncol Rep 54: 141, 2025.
APA
Wu, A., Ni, Y., Zhou, Y., & Shi, J. (2025). Emerging dual role of ferroptosis in lung cancer (Review). Oncology Reports, 54, 141. https://doi.org/10.3892/or.2025.8974
MLA
Wu, A., Ni, Y., Zhou, Y., Shi, J."Emerging dual role of ferroptosis in lung cancer (Review)". Oncology Reports 54.5 (2025): 141.
Chicago
Wu, A., Ni, Y., Zhou, Y., Shi, J."Emerging dual role of ferroptosis in lung cancer (Review)". Oncology Reports 54, no. 5 (2025): 141. https://doi.org/10.3892/or.2025.8974