Open Access

Comprehensive review of mouse models for studying cancer‑related fatigue: Methods, findings and future directions (Review)

  • Authors:
    • Hongxia Ge
    • Cuiping Xu
    • Liangliang Chu
  • View Affiliations

  • Published online on: July 21, 2025     https://doi.org/10.3892/etm.2025.12928
  • Article Number: 178
  • Copyright: © Ge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer‑related fatigue (CRF) is one of the most prevalent and debilitating symptoms experienced by patients with cancer, significantly impacting their quality of life. Currently, the precise mechanisms underlying the onset of this fatigue remain poorly understood, and there is a notable lack of effective pharmacological treatments to alleviate it. Therefore, establishing a reliable and stable mouse model of CRF is essential for advancing research in this important area. The present study systematically reviewed various methods for inducing CRF in mice, including tumor‑bearing models, chemotherapy and localized irradiation, either used alone or in combination. The advantages and disadvantages of each of these models were analyzed, providing researchers with valuable insights and references for selecting the most appropriate mouse model of CRF for their specific studies.
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September-2025
Volume 30 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Ge H, Xu C and Chu L: Comprehensive review of mouse models for studying cancer‑related fatigue: Methods, findings and future directions (Review). Exp Ther Med 30: 178, 2025.
APA
Ge, H., Xu, C., & Chu, L. (2025). Comprehensive review of mouse models for studying cancer‑related fatigue: Methods, findings and future directions (Review). Experimental and Therapeutic Medicine, 30, 178. https://doi.org/10.3892/etm.2025.12928
MLA
Ge, H., Xu, C., Chu, L."Comprehensive review of mouse models for studying cancer‑related fatigue: Methods, findings and future directions (Review)". Experimental and Therapeutic Medicine 30.3 (2025): 178.
Chicago
Ge, H., Xu, C., Chu, L."Comprehensive review of mouse models for studying cancer‑related fatigue: Methods, findings and future directions (Review)". Experimental and Therapeutic Medicine 30, no. 3 (2025): 178. https://doi.org/10.3892/etm.2025.12928