Open Access

Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review)

  • Authors:
    • Xuesong Chen
    • Bin Tian
    • Yiqun Wang
    • Jiang Zheng
    • Xin Kang
  • View Affiliations

  • Published online on: April 14, 2025     https://doi.org/10.3892/ijmm.2025.5533
  • Article Number: 92
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma, the most prevalent primary bone malignancy in children and adolescents, poses significant challenges due to its aggressive nature and propensity for metastasis. Despite advances in treatment, survival rates for high‑risk patients remain unsatisfactory, underscoring the urgent need for innovative approaches. This review explores the vital role of multi‑omics‑integrating genomics, transcriptomics, proteomics and metabolomics‑in unraveling the complex biological landscapes of osteosarcoma. By providing comprehensive insights into tumor heterogeneity, signaling pathways and metabolic reprogramming, multi‑omics facilitates the identification of novel biomarkers and therapeutic targets. The objective of the present study was to highlight the transformative potential of multi‑omics in enhancing the understanding and management of osteosarcoma, ultimately paving the way for personalized treatment strategies and improved patient outcomes. Through this synthesis, the study calls for a concerted effort to integrate multi‑omics into clinical practice, fostering a more precise approach to osteosarcoma care.
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June-2025
Volume 55 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Tian B, Wang Y, Zheng J and Kang X: Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review). Int J Mol Med 55: 92, 2025.
APA
Chen, X., Tian, B., Wang, Y., Zheng, J., & Kang, X. (2025). Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review). International Journal of Molecular Medicine, 55, 92. https://doi.org/10.3892/ijmm.2025.5533
MLA
Chen, X., Tian, B., Wang, Y., Zheng, J., Kang, X."Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review)". International Journal of Molecular Medicine 55.6 (2025): 92.
Chicago
Chen, X., Tian, B., Wang, Y., Zheng, J., Kang, X."Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review)". International Journal of Molecular Medicine 55, no. 6 (2025): 92. https://doi.org/10.3892/ijmm.2025.5533