Open Access

Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)

  • Authors:
    • Hanxing Cheng
    • Wanying Yang
    • Huaiyi Xu
    • Wenwen Zhu
    • Ailin Gong
    • Xuemei Yang
    • Sen Li
    • Houping Xu
  • View Affiliations

  • Published online on: June 30, 2025     https://doi.org/10.3892/ijmm.2025.5571
  • Article Number: 130
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Sleep plays a crucial role in maintaining and improving physical and mental health. However, the prevalence of sleep disorders is increasing in modern society. Recently, the gut‑brain axis has emerged as a prominent focus within the realm of sleep disorder research, with gut microbiota metabolites serving as essential factors in gut‑brain communication. The present study summarizes the emerging connections between gut microbiota metabolites and sleep, mainly focusing on those derived from tryptophan and dietary fiber metabolism. It discusses potential pathways and molecular processes by which sleep interacts with the gut microbiota metabolites, aiming to evaluate the feasibility of using gut microbiota interventions to treat sleep disorders.
View Figures
View References

Related Articles

Journal Cover

September-2025
Volume 56 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng H, Yang W, Xu H, Zhu W, Gong A, Yang X, Li S and Xu H: Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review). Int J Mol Med 56: 130, 2025.
APA
Cheng, H., Yang, W., Xu, H., Zhu, W., Gong, A., Yang, X. ... Xu, H. (2025). Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review). International Journal of Molecular Medicine, 56, 130. https://doi.org/10.3892/ijmm.2025.5571
MLA
Cheng, H., Yang, W., Xu, H., Zhu, W., Gong, A., Yang, X., Li, S., Xu, H."Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)". International Journal of Molecular Medicine 56.3 (2025): 130.
Chicago
Cheng, H., Yang, W., Xu, H., Zhu, W., Gong, A., Yang, X., Li, S., Xu, H."Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)". International Journal of Molecular Medicine 56, no. 3 (2025): 130. https://doi.org/10.3892/ijmm.2025.5571