Open Access

Effects of anti‑VEGF on peripapillary retinal nerve fiber layer and papillary/peripapillary blood circulation in retinopathies (Review)

  • Authors:
    • Hongwei Wang
    • Renfeng Ding
    • Wenya Jiang
    • Siyi Li
    • Yijuan Wu
    • Junfeng Mao
    • Yanan Chen
    • Peng Sun
    • Mengqi Shi
  • View Affiliations

  • Published online on: July 2, 2025     https://doi.org/10.3892/ijmm.2025.5574
  • Article Number: 133
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Vascular endothelial growth factor (VEGF) is an endothelial cell‑specific angiogenic factor. VEGF is involved in vasodilatation, nerve protection and retinal development and maturation. Over‑expression of VEGF is closely associated with retinopathies, such as retinal vein occlusion, diabetic retinopathy, age‑related macular degeneration and diabetic macular edema. Intravitreal injections of anti‑VEGFs are widely used in the treatment of retinopathies to reduce the angiogenesis and the macular edema. Hypothetically, repeated anti‑VEGF injections for retinopathies should interfere with the neuroprotective function of VEGF and might induce the vasoconstriction with a subsequent decrease in the ocular perfusion. These two could affect the optic nerve. The peripapillary retinal nerve fiber layer (p‑RNFL) thinning and the decreased papillary/peripapillary blood circulation can show the optic nerve damage earlier. In the present review, the effects of anti‑VEGFs on p‑RNFL and papillary/peripapillary blood circulation in retinopathies were comprehensively summarized and analyzed to explore whether the anti‑VEGFs cause damages to the optic nerve. The present review provided a detailed evaluation and analysis of the changes in p‑RNFL thickness, papillary/peripapillary blood circulation and intraocular pressure and the correlations between these changes with the number and type of anti‑VEGFs in 3,078 affected eyes and 520 fellow eyes with retinopathies. The present review sought to establish a foundation for the intravitreal administration of anti‑VEGFs and efficacy monitoring of the possible side effects on the optic nerve.
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September-2025
Volume 56 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wang H, Ding R, Jiang W, Li S, Wu Y, Mao J, Chen Y, Sun P and Shi M: Effects of anti‑VEGF on peripapillary retinal nerve fiber layer and papillary/peripapillary blood circulation in retinopathies (Review). Int J Mol Med 56: 133, 2025.
APA
Wang, H., Ding, R., Jiang, W., Li, S., Wu, Y., Mao, J. ... Shi, M. (2025). Effects of anti‑VEGF on peripapillary retinal nerve fiber layer and papillary/peripapillary blood circulation in retinopathies (Review). International Journal of Molecular Medicine, 56, 133. https://doi.org/10.3892/ijmm.2025.5574
MLA
Wang, H., Ding, R., Jiang, W., Li, S., Wu, Y., Mao, J., Chen, Y., Sun, P., Shi, M."Effects of anti‑VEGF on peripapillary retinal nerve fiber layer and papillary/peripapillary blood circulation in retinopathies (Review)". International Journal of Molecular Medicine 56.3 (2025): 133.
Chicago
Wang, H., Ding, R., Jiang, W., Li, S., Wu, Y., Mao, J., Chen, Y., Sun, P., Shi, M."Effects of anti‑VEGF on peripapillary retinal nerve fiber layer and papillary/peripapillary blood circulation in retinopathies (Review)". International Journal of Molecular Medicine 56, no. 3 (2025): 133. https://doi.org/10.3892/ijmm.2025.5574