Ralapanawa U and Sivakanesan R: Epidemiology and the magnitude of coronary artery disease and acute coronary syndrome: A narrative review. J Epidemiol Glob Health. 11:169–177. 2021. View Article : Google Scholar : PubMed/NCBI

Pagliaro BR, Cannata F, Stefanini GG and Bolognese L: Myocardial ischemia and coronary disease in heart failure. Heart Fail Rev. 25:53–65. 2020. View Article : Google Scholar

Horowitz LN, Harken AH, Josephson ME and Kastor JA: Surgical treatment of ventricular arrhythmias in coronary artery disease. Ann Intern Med. 95:88–97. 1981. View Article : Google Scholar : PubMed/NCBI

Sara JD, Eleid MF, Gulati R and Holmes DR Jr: Sudden cardiac death from the perspective of coronary artery disease. Mayo Clin Proc. 89:1685–1698. 2014. View Article : Google Scholar : PubMed/NCBI

Russell MW, Huse DM, Drowns S, Hamel EC and Hartz SC: Direct medical costs of coronary artery disease in the United States. Am J Cardiol. 81:1110–1115. 1998. View Article : Google Scholar : PubMed/NCBI

Ference BA, Yoo W, Alesh I, Mahajan N, Mirowska KK, Mewada A, Kahn J, Afonso L, Williams KA Sr and Flack JM: Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: A Mendelian randomization analysis. J Am Coll Cardiol. 60:2631–2639. 2012. View Article : Google Scholar : PubMed/NCBI

Toth PP: High-density lipoprotein and cardiovascular risk. Circulation. 109:1809–1812. 2004. View Article : Google Scholar : PubMed/NCBI

Gallo G, Volpe M and Savoia C: Endothelial dysfunction in hypertension: Current concepts and clinical implications. Front Med (Lausanne). 8:7989582022. View Article : Google Scholar : PubMed/NCBI

Yang DR, Wang MY, Zhang CL and Wang Y: Endothelial dysfunction in vascular complications of diabetes: A comprehensive review of mechanisms and implications. Front Endocrinol (Lausanne). 15:13592552024. View Article : Google Scholar : PubMed/NCBI

Alpert JS: New coronary heart disease risk factors. Am J Med. 136:331–332. 2023. View Article : Google Scholar

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A and Chakraborty S: A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 234:16812–16823. 2019. View Article : Google Scholar : PubMed/NCBI

Nettleship J, Jones R, Channer K and Jones T: Testosterone and coronary artery disease. Front Horm Res. 37:91–107. 2009. View Article : Google Scholar

Bauersachs R, Zeymer U, Brière JB, Marre C, Bowrin K and Huelsebeck M: Burden of coronary artery disease and peripheral artery disease: A literature review. Cardiovasc Ther. 2019:82950542019. View Article : Google Scholar

Lee YTH, Fang J, Schieb L, Park S, Casper M and Gillespie C: Prevalence and trends of coronary heart disease in the United States, 2011 to 2018. JAMA Cardiol. 7:459–462. 2022. View Article : Google Scholar : PubMed/NCBI

Libby P and Theroux P: Pathophysiology of coronary artery disease. Circulation. 111:3481–3488. 2005. View Article : Google Scholar : PubMed/NCBI

Weber C and Noels H: Atherosclerosis: Current pathogenesis and therapeutic options. Nat Med. 17:1410–1422. 2011. View Article : Google Scholar : PubMed/NCBI

Attiq A, Afzal S, Ahmad W and Kandeel M: Hegemony of inflammation in atherosclerosis and coronary artery disease. Eur J Pharmacol. 966:1763382024. View Article : Google Scholar : PubMed/NCBI

Chen Y, Yu Y, Zou W, Zhang M, Wang Y and Gu Y: Association between cardiac autonomic nervous dysfunction and the severity of coronary lesions in patients with stable coronary artery disease. J Int Med Res. 46:3729–3740. 2018. View Article : Google Scholar : PubMed/NCBI

Parisi AF, Folland ED and Hartigan P: A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. Veterans affairs ACME investigators. N Engl J Med. 326:10–16. 1992. View Article : Google Scholar : PubMed/NCBI

Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, et al: Coronary-artery bypass surgery in patients with ischemic cardiomyopathy. N Engl J Med. 374:1511–1520. 2016. View Article : Google Scholar : PubMed/NCBI

Del Buono MG, Montone RA, Camilli M, Carbone S, Narula J, Lavie CJ, Niccoli G and Crea F: Coronary microvascular dysfunction across the spectrum of cardiovascular diseases: JACC state-of-the-art review. J Am Coll Cardiol. 78:1352–1371. 2021. View Article : Google Scholar : PubMed/NCBI

Silvani A, Calandra-Buonaura G, Dampney RAL and Cortelli P: Brain-heart interactions: Physiology and clinical implications. Philos Trans A Math Phys Eng Sci. 374:201501812016.PubMed/NCBI

Wehrwein EA, Orer HS and Barman SM: Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system. Compr Physiol. 6:1239–1278. 2016. View Article : Google Scholar : PubMed/NCBI

Silva LEV, Silva CAA, Salgado HC and Fazan R Jr: The role of sympathetic and vagal cardiac control on complexity of heart rate dynamics. Am J Physiol Heart Circ Physiol. 312:H469–H477. 2017. View Article : Google Scholar

Charkoudian N and Rabbitts JA: Sympathetic neural mechanisms in human cardiovascular health and disease. Mayo Clin Proc. 84:822–830. 2009. View Article : Google Scholar : PubMed/NCBI

Kasahara Y, Yoshida C, Saito M and Kimura Y: Assessments of heart rate and sympathetic and parasympathetic nervous activities of normal mouse fetuses at different stages of fetal development using fetal electrocardiography. Front Physiol. 12:6528282021. View Article : Google Scholar : PubMed/NCBI

Curtis BM and O'Keefe JH Jr: Autonomic tone as a cardiovascular risk factor: The dangers of chronic fight or flight. Mayo Clin Proc. 77:45–54. 2002. View Article : Google Scholar : PubMed/NCBI

Brunner-La Rocca HP, Esler MD, Jennings GL and Kaye DM: Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure. Eur Heart J. 22:1136–1143. 2001. View Article : Google Scholar : PubMed/NCBI

Hadaya J and Ardell JL: Autonomic modulation for cardiovascular disease. Front Physiol. 11:6174592020. View Article : Google Scholar

Shen MJ and Zipes DP: Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 114:1004–1021. 2014. View Article : Google Scholar : PubMed/NCBI

Malpas SC: Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev. 90:513–557. 2010. View Article : Google Scholar : PubMed/NCBI

Grassi G and Drager LF: Sympathetic overactivity, hypertension and cardiovascular disease: State of the art. Curr Med Res Opin. 40(Suppl 1): S5–S13. 2024. View Article : Google Scholar

Bazoukis G, Stavrakis S and Armoundas AA: Vagus nerve stimulation and inflammation in cardiovascular disease: A state-of-the-art review. J Am Heart Assoc. 12:e0305392023. View Article : Google Scholar : PubMed/NCBI

Capilupi MJ, Kerath SM and Becker LB: Vagus nerve stimulation and the cardiovascular system. Cold Spring Harb Perspect Med. 10:a0341732020. View Article : Google Scholar

De Ferrari GM and Schwartz PJ: Vagus nerve stimulation: from pre-clinical to clinical application: Challenges and future directions. Heart Fail Rev. 16:195–203. 2011. View Article : Google Scholar

Deer TR, Levy RM, Kramer J, Poree L, Amirdelfan K, Grigsby E, Staats P, Burton AW, Burgher AH, Obray J, et al: Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: A randomized comparative trial. Pain. 158:669–681. 2017. View Article : Google Scholar :

Bernstein SA, Wong B, Vasquez C, Rosenberg SP, Rooke R, Kuznekoff LM, Lader JM, Mahoney VM, Budylin T, Älvstrand M, et al: Spinal cord stimulation protects against atrial fibrillation induced by tachypacing. Heart Rhythm. 9:1426–1433.e3. 2012. View Article : Google Scholar : PubMed/NCBI

Torre-Amione G, Alo K, Estep JD, Valderrabano M, Khalil N, Farazi TG, Rosenberg SP, Ness L and Gill J: Spinal cord stimulation is safe and feasible in patients with advanced heart failure: Early clinical experience. Eur J Heart Fail. 16:788–795. 2014. View Article : Google Scholar : PubMed/NCBI

Cucinotta F, Swinnen B, Makovac E, Hirschbichler S, Pereira E, Little S, Morgante F and Ricciardi L: Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: A systematic review. J Neurol. 271:3764–3776. 2024. View Article : Google Scholar : PubMed/NCBI

Clancy JA, Johnson R, Raw R, Deuchars SA and Deuchars J: Anodal transcranial direct current stimulation (tDCS) over the motor cortex increases sympathetic nerve activity. Brain Stimul. 7:97–104. 2014. View Article : Google Scholar

Lee H, Lee JH, Hwang MH and Kang N: Repetitive transcranial magnetic stimulation improves cardiovascular autonomic nervous system control: A meta-analysis. J Affect Disord. 339:443–453. 2023. View Article : Google Scholar : PubMed/NCBI

De Decker K, Beese U, Staal MJ and Dejongste MJL: Electrical neuromodulation for patients with cardiac diseases. Neth Heart J. 21:91–94. 2013. View Article : Google Scholar :

Zipes DP, Neuzil P, Theres H, Caraway D, Mann DL, Mannheimer C, Van Buren P, Linde C, Linderoth B, Kueffer F, et al: Determining the feasibility of spinal cord neuromodulation for the treatment of chronic systolic heart failure: The DEFEAT-HF study. JACC Heart Fail. 4:129–136. 2016. View Article : Google Scholar

Rodrigues B, Barboza CA, Moura EG, Ministro G, Ferreira-Melo SE, Castaño JB, Nunes WMS, Mostarda C, Coca A, Vianna LC and Moreno-Junior H: Acute and short-term autonomic and hemodynamic responses to transcranial direct current stimulation in patients with resistant hypertension. Front Cardiovasc Med. 9:8534272022. View Article : Google Scholar : PubMed/NCBI

Imran TF, Malapero R, Qavi AH, Hasan Z, de la Torre B, Patel YR, Yong RJ, Djousse L, Gaziano JM and Gerhard-Herman MD: Efficacy of spinal cord stimulation as an adjunct therapy for chronic refractory angina pectoris. Int J Cardiol. 227:535–542. 2017. View Article : Google Scholar

Palasubramaniam J, Wang X and Peter K: Myocardial infarction-from atherosclerosis to thrombosis. Arterioscler Thromb Vasc Biol. 39:e176–e185. 2019. View Article : Google Scholar : PubMed/NCBI

Libby P: Inflammation in atherosclerosis. Nature. 420:868–874. 2002. View Article : Google Scholar : PubMed/NCBI

Bradley C and Berry C: Definition and epidemiology of coronary microvascular disease. J Nucl Cardiol. 29:1763–1775. 2022. View Article : Google Scholar : PubMed/NCBI

Marinescu MA, Löffler AI, Ouellette M, Smith L, Kramer CM and Bourque JM: Coronary microvascular dysfunction, microvascular angina, and treatment strategies. JACC Cardiovasc Imaging. 8:210–220. 2015. View Article : Google Scholar : PubMed/NCBI

Gutiérrez E, Flammer AJ, Lerman LO, Elízaga J, Lerman A and Fernández-Avilés F: Endothelial dysfunction over the course of coronary artery disease. Eur Heart J. 34:3175–3181. 2013. View Article : Google Scholar : PubMed/NCBI

Bentzon JF, Otsuka F, Virmani R and Falk E: Mechanisms of plaque formation and rupture. Circ Res. 114:1852–1866. 2014. View Article : Google Scholar : PubMed/NCBI

Villa AD, Sammut E, Nair A, Rajani R, Bonamini R and Chiribiri A: Coronary artery anomalies overview: The normal and the abnormal. World J Radiol. 8:537–555. 2016. View Article : Google Scholar : PubMed/NCBI

Chen M, Wu X and Xu C: The 'hands' teaching method in coronary artery anatomy. Asian J Surg. 47:3183–3184. 2024. View Article : Google Scholar : PubMed/NCBI

Chilian WM and Marcus ML: Phasic coronary blood flow velocity in intramural and epicardial coronary arteries. Circ Res. 50:775–781. 1982. View Article : Google Scholar : PubMed/NCBI

De Bruyne B, Hersbach F, Pijls NH, Bartunek J, Bech JW, Heyndrickx GR, Gould KL and Wijns W: Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but 'normal' coronary angiography. Circulation. 104:2401–2406. 2001. View Article : Google Scholar : PubMed/NCBI

Camici PG and Rimoldi OE: The clinical value of myocardial blood flow measurement. J Nucl Med. 50:1076–1087. 2009. View Article : Google Scholar : PubMed/NCBI

Duncker DJ, Koller A, Merkus D and Canty JM Jr: Regulation of coronary blood flow in health and ischemic heart disease. Prog Cardiovasc Dis. 57:409–422. 2015. View Article : Google Scholar

Dedkov EI, Christensen LP, Weiss RM and Tomanek RJ: Reduction of heart rate by chronic beta1-adrenoceptor blockade promotes growth of arterioles and preserves coronary perfusion reserve in postinfarcted heart. Am J Physiol Heart Circ Physiol. 288:H2684–H2693. 2005. View Article : Google Scholar : PubMed/NCBI

Pruthi S, Siddiqui E and Smilowitz NR: Beyond coronary artery disease: Assessing the microcirculation. Interv Cardiol Clin. 12:119–129. 2023.

Palade GE: Blood capillaries of the heart and other organs. Circulation. 24:368–388. 1961. View Article : Google Scholar : PubMed/NCBI

Wolff CB: Normal cardiac output, oxygen delivery and oxygen extraction. Adv Exp Med Biol. 599:169–182. 2007. View Article : Google Scholar : PubMed/NCBI

Gandoy-Fieiras N, Gonzalez-Juanatey JR and Eiras S: Myocardium metabolism in physiological and pathophysiological states: Implications of epicardial adipose tissue and potential therapeutic targets. Int J Mol Sci. 21:26412020. View Article : Google Scholar : PubMed/NCBI

Hollenberg M and Tager IB: Oxygen uptake efficiency slope: An index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise. J Am Coll Cardiol. 36:194–201. 2000. View Article : Google Scholar : PubMed/NCBI

Downey JM: Myocardial contractile force as a function of coronary blood flow. Am J Physiol. 230:1–6. 1976. View Article : Google Scholar : PubMed/NCBI

Heusch G: Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: Benefit from selective bradycardic agents. Br J Pharmacol. 153:1589–1601. 2008. View Article : Google Scholar : PubMed/NCBI

Seligman H, Nijjer SS, van de Hoef TP, de Waard GA, Mejía-Rentería H, Echavarria-Pinto M, Shun-Shin MJ, Howard JP, Cook CM, Warisawa T, et al: Phasic flow patterns of right versus left coronary arteries in patients undergoing clinical physiological assessment. EuroIntervention. 17:1260–1270. 2022. View Article : Google Scholar

Comunale G, Peruzzo P, Castaldi B, Razzolini R, Di Salvo G, Padalino MA and Susin FM: Understanding and recognition of the right ventricular function and dysfunction via a numerical study. Sci Rep. 11:37092021. View Article : Google Scholar : PubMed/NCBI

Nikorowitsch J, Bei der Kellen R, Haack A, Magnussen C, Prochaska J, Wild PS, Dörr M, Twerenbold R, Schnabel RB, Kirchhof P, et al: Correlation of systolic and diastolic blood pressure with echocardiographic phenotypes of cardiac structure and function from three German population-based studies. Sci Rep. 13:145252023. View Article : Google Scholar : PubMed/NCBI

Yang HJ, Dey D, Sykes J, Klein M, Butler J, Kovacs MS, Sobczyk O, Sharif B, Bi X, Kali A, et al: Arterial CO₂ as a potent coronary vasodilator: A preclinical PET/MR validation study with implications for cardiac stress testing. J Nucl Med. 58:953–960. 2017. View Article : Google Scholar : PubMed/NCBI

Shryock JC, Snowdy S, Baraldi PG, Cacciari B, Spalluto G, Monopoli A, Ongini E, Baker SP and Belardinelli L: A2A-adenosine receptor reserve for coronary vasodilation. Circulation. 98:711–718. 1998. View Article : Google Scholar : PubMed/NCBI

Mori K, Nakaya Y, Sakamoto S, Hayabuchi Y, Matsuoka S and Kuroda Y: Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels. J Mol Cell Cardiol. 30:349–356. 1998. View Article : Google Scholar : PubMed/NCBI

Tarnow J, Brückner JB, Eberlein HJ, Gethmann JW, Hess W, Patschke D and Wilde J: Blood pH and PaCO2 as chemical factors in myocardial blood flow control. Basic Res Cardiol. 70:685–696. 1975. View Article : Google Scholar : PubMed/NCBI

Ishizaka H and Kuo L: Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle. Circ Res. 78:50–57. 1996. View Article : Google Scholar : PubMed/NCBI

Knot HJ, Zimmermann PA and Nelson MT: Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. J Physiol. 492:419–430. 1996. View Article : Google Scholar : PubMed/NCBI

Dora KA, Borysova L, Ye X, Powell C, Beleznai TZ, Stanley CP, Bruno VD, Starborg T, Johnson E, Pielach A, et al: Human coronary microvascular contractile dysfunction associates with viable synthetic smooth muscle cells. Cardiovasc Res. 118:1978–1992. 2022. View Article : Google Scholar :

Zhuge Y, Zhang J, Qian F, Wen Z, Niu C, Xu K, Ji H, Rong X, Chu M and Jia C: Role of smooth muscle cells in cardiovascular disease. Int J Biol Sci. 16:2741–2751. 2020. View Article : Google Scholar : PubMed/NCBI

Young MA, Knight DR and Vatner SF: Autonomic control of large coronary arteries and resistance vessels. Prog Cardiovasc Dis. 30:211–234. 1987. View Article : Google Scholar : PubMed/NCBI

Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P and Shah AM: Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation. 119:2656–2662. 2009. View Article : Google Scholar : PubMed/NCBI

Schrör K: Possible role of prostaglandins in the regulation of coronary blood flow. Basic Res Cardiol. 76:239–249. 1981. View Article : Google Scholar : PubMed/NCBI

Dharmashankar K and Widlansky ME: Vascular endothelial function and hypertension: Insights and directions. Curr Hypertens Rep. 12:448–455. 2010. View Article : Google Scholar : PubMed/NCBI

Lu Y, Cui X, Zhang L, Wang X, Xu Y, Qin Z, Liu G, Wang Q, Tian K, Lim KS, et al: The functional role of lipoproteins in atherosclerosis: Novel directions for diagnosis and targeting therapy. Aging Dis. 13:491–520. 2022. View Article : Google Scholar : PubMed/NCBI

Kobayashi Y, Sakai C, Ishida T, Nagata M, Nakano Y and Ishida M: Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression. Hypertens Res. 47:88–101. 2024. View Article : Google Scholar

Mundi S, Massaro M, Scoditti E, Carluccio MA, van Hinsbergh VWM, Iruela-Arispe ML and De Caterina R: Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review. Cardiovasc Res. 114:35–52. 2018. View Article : Google Scholar

Falk E: Pathogenesis of atherosclerosis. J Am Coll Cardiol. 47(8 Suppl): C7–C12. 2006. View Article : Google Scholar : PubMed/NCBI

Aviram M: Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins. Antioxid Redox Signal. 1:585–594. 1999. View Article : Google Scholar

Willemsen L and de Winther MP: Macrophage subsets in atherosclerosis as defined by single-cell technologies. J Pathol. 250:705–714. 2020. View Article : Google Scholar : PubMed/NCBI

Newby AC and Zaltsman AB: Fibrous cap formation or destruction-the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation. Cardiovasc Res. 41:345–360. 1999. View Article : Google Scholar : PubMed/NCBI

Allahverdian S, Chehroudi AC, McManus BM, Abraham T and Francis GA: Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation. 129:1551–1559. 2014. View Article : Google Scholar : PubMed/NCBI

Rong JX, Shapiro M, Trogan E and Fisher EA: Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading. Proc Natl Acad Sci USA. 100:13531–13536. 2003. View Article : Google Scholar : PubMed/NCBI

Ajoolabady A, Pratico D, Lin L, Mantzoros CS, Bahijri S, Tuomilehto J and Ren J: Inflammation in atherosclerosis: Pathophysiology and mechanisms. Cell Death Dis. 15:8172024. View Article : Google Scholar : PubMed/NCBI

Song B, Bie Y, Feng H, Xie B, Liu M and Zhao F: Inflammatory factors driving atherosclerotic plaque progression new insights. J Transl Int Med. 10:36–47. 2022. View Article : Google Scholar : PubMed/NCBI

Francisco J and Del Re DP: Inflammation in myocardial ischemia/reperfusion injury: Underlying mechanisms and therapeutic potential. Antioxidants (Basel). 12:19442023. View Article : Google Scholar : PubMed/NCBI

Bennett MR, Sinha S and Owens GK: Vascular smooth muscle cells in atherosclerosis. Circ Res. 118:692–702. 2016. View Article : Google Scholar : PubMed/NCBI

Otsuka F, Kramer MCA, Woudstra P, Yahagi K, Ladich E, Finn AV, de Winter RJ, Kolodgie FD, Wight TN, Davis HR, et al: Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study. Atherosclerosis. 241:772–782. 2015. View Article : Google Scholar : PubMed/NCBI

Badimon L and Vilahur G: Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med. 276:618–632. 2014. View Article : Google Scholar : PubMed/NCBI

Kumar A, Kar S and Fay WP: Thrombosis, physical activity, and acute coronary syndromes. J Appl Physiol (1985). 111:599–605. 2011. View Article : Google Scholar : PubMed/NCBI

Ha EJ, Kim Y, Cheung JY and Shim SS: Coronary artery disease in asymptomatic young adults: Its prevalence according to coronary artery disease risk stratification and the CT characteristics. Korean J Radiol. 11:425–432. 2010. View Article : Google Scholar : PubMed/NCBI

Dzaye O, Razavi AC, Blaha MJ and Mortensen MB: Evaluation of coronary stenosis versus plaque burden for atherosclerotic cardiovascular disease risk assessment and management. Curr Opin Cardiol. 36:769–775. 2021. View Article : Google Scholar : PubMed/NCBI

Kragel AH, Reddy SG, Wittes JT and Roberts WC: Morphometric analysis of the composition of atherosclerotic plaques in the four major epicardial coronary arteries in acute myocardial infarction and in sudden coronary death. Circulation. 80:1747–1756. 1989. View Article : Google Scholar : PubMed/NCBI

Servoss SJ, Januzzi JL and Muller JE: Triggers of acute coronary syndromes. Prog Cardiovasc Dis. 44:369–380. 2002. View Article : Google Scholar : PubMed/NCBI

Burke AP, Kolodgie FD, Farb A, Weber DK, Malcom GT, Smialek J and Virmani R: Healed plaque ruptures and sudden coronary death: Evidence that subclinical rupture has a role in plaque progression. Circulation. 103:934–940. 2001. View Article : Google Scholar : PubMed/NCBI

Amabile N and Veugeois A: Ruptured and healed atherosclerotic plaques: Breaking bad? EuroIntervention. 15:e742–e744. 2019. View Article : Google Scholar : PubMed/NCBI

Rittersma SZH, van der Wal AC, Koch KT, Piek JJ, Henriques JP, Mulder KJ, Ploegmakers JP, Meesterman M and de Winter RJ: Plaque instability frequently occurs days or weeks before occlusive coronary thrombosis: A pathological thrombectomy study in primary percutaneous coronary intervention. Circulation. 111:1160–1165. 2005. View Article : Google Scholar : PubMed/NCBI

Fernández-Ortiz A, Badimon JJ, Falk E, Fuster V, Meyer B, Mailhac A, Weng D, Shah PK and Badimon L: Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture. J Am Coll Cardiol. 23:1562–1569. 1994. View Article : Google Scholar : PubMed/NCBI

Silvain J, Collet JP, Nagaswami C, Beygui F, Edmondson KE, Bellemain-Appaix A, Cayla G, Pena A, Brugier D, Barthelemy O, et al: Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol. 57:1359–1367. 2011. View Article : Google Scholar : PubMed/NCBI

Mohammed AQ, Abdu FA, Liu L, Yin G, Mareai RM, Mohammed AA, Xu Y and Che W: Coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries: Where do we stand? Eur J Intern Med. 117:8–20. 2023. View Article : Google Scholar : PubMed/NCBI

Herrmann J, Kaski JC and Lerman A: Coronary microvascular dysfunction in the clinical setting: From mystery to reality. Eur Heart J. 33:2771–2782b. 2012. View Article : Google Scholar : PubMed/NCBI

Sinha A, Rahman H and Perera D: Coronary microvascular disease: Current concepts of pathophysiology, diagnosis and management. Cardiovasc Endocrinol Metab. 10:22–30. 2021. View Article : Google Scholar : PubMed/NCBI

Rezaeian P, Shufelt CL, Wei J, Pacheco C, Cook-Wiens G, Berman D, Tamarappoo B, Thomson LE, Nelson MD, Anderson RD, et al: Arterial stiffness assessment in coronary microvascular dysfunction and heart failure with preserved ejection fraction: An initial report from the WISE-CVD continuation study. Am Heart J Plus. 41:1003902024.PubMed/NCBI

Singh A, Ashraf S, Irfan H, Venjhraj F, Verma A, Shaukat A, Tariq MD and Hamza HM: Heart failure and microvascular dysfunction: An in-depth review of mechanisms, diagnostic strategies, and innovative therapies. Ann Med Surg (Lond). 87:616–626. 2024. View Article : Google Scholar

Li M, Qian M, Kyler K and Xu J: Endothelial-vascular smooth muscle cells interactions in atherosclerosis. Front Cardiovasc Med. 5:1512018. View Article : Google Scholar : PubMed/NCBI

Medina-Leyte DJ, Zepeda-García O, Domínguez-Pérez M, González-Garrido A, Villarreal-Molina T and Jacobo-Albavera L: Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches. Int J Mol Sci. 22:38502021. View Article : Google Scholar : PubMed/NCBI

Fleissner F and Thum T: Critical role of the nitric oxide/reactive oxygen species balance in endothelial progenitor dysfunction. Antioxid Redox Signal. 15:933–948. 2011. View Article : Google Scholar :

Goodwill AG, Dick GM, Kiel AM and Tune JD: Regulation of coronary blood flow. Compr Physiol. 7:321–382. 2017. View Article : Google Scholar : PubMed/NCBI

Maddox TM, Stanislawski MA, Grunwald GK, Bradley SM, Ho PM, Tsai TT, Patel MR, Sandhu A, Valle J, Magid DJ, et al: Nonobstructive coronary artery disease and risk of myocardial infarction. JAMA. 312:1754–1763. 2014. View Article : Google Scholar : PubMed/NCBI

Heusch G: Myocardial ischemia: Lack of coronary blood flow or myocardial oxygen supply/demand imbalance? Circ Res. 119:194–196. 2016. View Article : Google Scholar : PubMed/NCBI

Pasupathy S, Tavella R and Beltrame JF: Myocardial infarction with nonobstructive coronary arteries (MINOCA): The past, present, and future management. Circulation. 135:1490–1493. 2017. View Article : Google Scholar : PubMed/NCBI

Ford TJ, Rocchiccioli P, Good R, McEntegart M, Eteiba H, Watkins S, Shaukat A, Lindsay M, Robertson K, Hood S, et al: Systemic microvascular dysfunction in microvascular and vasospastic angina. Eur Heart J. 39:4086–4097. 2018. View Article : Google Scholar : PubMed/NCBI

Mohri M, Koyanagi M, Egashira K, Tagawa H, Ichiki T, Shimokawa H and Takeshita A: Angina pectoris caused by coronary microvascular spasm. Lancet. 351:1165–1169. 1998. View Article : Google Scholar : PubMed/NCBI

Mehta PK, Thobani A and Vaccarino V: Coronary artery spasm, coronary reactivity, and their psychological context. Psychosom Med. 81:233–236. 2019. View Article : Google Scholar : PubMed/NCBI

Hung MJ, Hu P and Hung MY: Coronary artery spasm: Review and update. Int J Med Sci. 11:1161–1171. 2014. View Article : Google Scholar : PubMed/NCBI

Igarashi Y, Yamazoe M and Shibata A: Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina. Am Heart J. 121:1094–1100. 1991. View Article : Google Scholar : PubMed/NCBI

Frantz RP, Lerman A, Edwards BS, Olson LJ, Higano ST, Schwartz RS, Daly RC, McGregor CG and Rodeheffer RJ: Methylergonovine-induced diffuse coronary spasm in a patient with exercise-induced coronary spasm after heart transplantation. J Heart Lung Transplant. 13:834–839. 1994.PubMed/NCBI

Doenst T, Thiele H, Haasenritter J, Wahlers T, Massberg S and Haverich A: The treatment of coronary artery disease. Dtsch Arztebl Int. 119:716–723. 2022.PubMed/NCBI

Hennekens CH: Aspirin in the treatment and prevention of cardiovascular disease. Annu Rev Public Health. 18:37–49. 1997. View Article : Google Scholar : PubMed/NCBI

Sabatine MS, Wiviott SD, Im K, Murphy SA and Giugliano RP: Efficacy and safety of further lowering of low-density lipoprotein cholesterol in patients starting with very low levels: A meta-analysis. JAMA Cardiol. 3:823–828. 2018. View Article : Google Scholar : PubMed/NCBI

Manikandan A, Moharil P, Sathishkumar M, Muñoz-Garay C and Sivakumar A: Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and structure-activity relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential. Eur J Med Chem. 141:417–426. 2017. View Article : Google Scholar : PubMed/NCBI

Godoy LC, Farkouh ME, Austin PC, Shah BR, Qiu F, Jackevicius CA, Wijeysundera HC, Krumholz HM and Ko DT: Association of beta-blocker therapy with cardiovascular outcomes in patients with stable ischemic heart disease. J Am Coll Cardiol. 81:2299–2311. 2023. View Article : Google Scholar : PubMed/NCBI

Yan Y, An W, Mei S, Zhu Q, Li C, Yang L, Zhao Z and Huo J: Real-world research on beta-blocker usage trends in China and safety exploration based on the FDA adverse event reporting system (FAERS). BMC Pharmacol Toxicol. 25:862024. View Article : Google Scholar : PubMed/NCBI

Elliott WJ and Ram CVS: Calcium channel blockers. J Clin Hypertens (Greenwich). 13:687–689. 2011. View Article : Google Scholar : PubMed/NCBI

Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S and Malinski T: Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: A novel mechanism for antihypertensive action. Circulation. 107:2747–2752. 2003. View Article : Google Scholar : PubMed/NCBI

Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, et al: 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: Executive summary: A report of the American college of cardiology/american heart association joint committee on clinical practice guidelines. Circulation. 145:e4–e17. 2022.

Head SJ, Kieser TM, Falk V, Huysmans HA and Kappetein AP: Coronary artery bypass grafting: Part 1-the evolution over the first 50 years. Eur Heart J. 34:2862–2872. 2013. View Article : Google Scholar : PubMed/NCBI

Costa MACD, Betero AL, Okamoto J, Schafranski M, Reis ESD and Gomes RZ: Coronary endarterectomy: A case control study and evaluation of early patency rate of endarterectomized arteries. Braz J Cardiovasc Surg. 35:9–15. 2020.PubMed/NCBI

González-Montero J, Brito R, Gajardo AI and Rodrigo R: Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. World J Cardiol. 10:74–86. 2018. View Article : Google Scholar : PubMed/NCBI

Hausenloy DJ and Yellon DM: Myocardial ischemia-reperfusion injury: A neglected therapeutic target. J Clin Invest. 123:92–100. 2013. View Article : Google Scholar : PubMed/NCBI

McBride W, Lange RA and Hillis LD: Restenosis after successful coronary angioplasty. Pathophysiology and prevention. N Engl J Med. 318:1734–1737. 1988. View Article : Google Scholar : PubMed/NCBI

Smart NA, Dieberg G and King N: Long-term outcomes of on-versus off-pump coronary artery bypass grafting. J Am Coll Cardiol. 71:983–991. 2018. View Article : Google Scholar : PubMed/NCBI

Camici PG and Crea F: Coronary microvascular dysfunction. N Engl J Med. 356:830–840. 2007. View Article : Google Scholar : PubMed/NCBI

Roffi M, Meier B and Gallino A: Fifty years of percutaneous transluminal angioplasty. Eur Heart J. 45:1779–1780. 2024. View Article : Google Scholar : PubMed/NCBI

Ruel M and Chikwe J: Coronary artery bypass grafting: Past and future. Circulation. 150:1067–1069. 2024. View Article : Google Scholar : PubMed/NCBI

Rocco E, Grimaldi MC, Maino A, Cappannoli L, Pedicino D, Liuzzo G and Biasucci LM: Advances and challenges in biomarkers use for coronary microvascular dysfunction: From bench to clinical practice. J Clin Med. 11:20552022. View Article : Google Scholar : PubMed/NCBI

Soleymani M, Masoudkabir F, Shabani M, Vasheghani-Farahani A, Behnoush AH and Khalaji A: Updates on pharmacologic management of microvascular angina. Cardiovasc Ther. 2022:60802582022. View Article : Google Scholar : PubMed/NCBI

Yang L, Zhao W, Kan Y, Ren C and Ji X: From mechanisms to medicine: Neurovascular coupling in the diagnosis and treatment of cerebrovascular disorders: A narrative review. Cells. 14:162024. View Article : Google Scholar

Bairey Merz CN, Pepine CJ, Shimokawa H and Berry C: Treatment of coronary microvascular dysfunction. Cardiovasc Res. 116:856–870. 2020. View Article : Google Scholar : PubMed/NCBI

Fatima M, Bazarbaev A, Rana A, Khurshid R, Effiom V, Bajwa NK, Nasir A, Candelario K, Tabraiz SA, Colon S, et al: Neuroprotective strategies in coronary artery disease interventions. J Cardiovasc Dev Dis. 12:1432025.PubMed/NCBI

Manolis AA, Manolis TA, Apostolopoulos EJ, Apostolaki NE, Melita H and Manolis AS: The role of the autonomic nervous system in cardiac arrhythmias: The neuro-cardiac axis, more foe than friend? Trends Cardiovasc Med. 31:290–302. 2021. View Article : Google Scholar

Armour JA: Functional anatomy of intrathoracic neurons innervating the atria and ventricles. Heart Rhythm. 7:994–996. 2010. View Article : Google Scholar : PubMed/NCBI

Brodde OE, Bruck H, Leineweber K and Seyfarth T: Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart. Basic Res Cardiol. 96:528–538. 2001. View Article : Google Scholar

Kawashima T: The autonomic nervous system of the human heart with special reference to its origin, course, and peripheral distribution. Anat Embryol (Berl). 209:425–438. 2005. View Article : Google Scholar : PubMed/NCBI

Burnstock G: Autonomic neurotransmission: 60 Years since sir henry dale. Annu Rev Pharmacol Toxicol. 49:1–30. 2009. View Article : Google Scholar

Nikolaidis LA, Trumble D, Hentosz T, Doverspike A, Huerbin R, Mathier MA, Shen YT and Shannon RP: Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO2 cost of catecholamines in heart failure). Eur J Heart Fail. 6:409–419. 2004. View Article : Google Scholar : PubMed/NCBI

Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, et al: Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nat Commun. 10:19442019. View Article : Google Scholar : PubMed/NCBI

Machhada A, Hosford PS, Dyson A, Ackland GL, Mastitskaya S and Gourine AV: Optogenetic stimulation of vagal efferent activity preserves left ventricular function in experimental heart failure. JACC Basic Transl Sci. 5:799–810. 2020. View Article : Google Scholar : PubMed/NCBI

Finlay M, Harmer SC and Tinker A: The control of cardiac ventricular excitability by autonomic pathways. Pharmacol Ther. 174:97–111. 2017. View Article : Google Scholar : PubMed/NCBI

Kawano H, Okada R and Yano K: Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels. 18:32–39. 2003. View Article : Google Scholar : PubMed/NCBI

Liu X, Yu Y, Zhang H, Zhang M and Liu Y: The role of muscarinic acetylcholine receptor M₃ in cardiovascular diseases. Int J Mol Sci. 25:75602024. View Article : Google Scholar

Giannino G, Braia V, Griffith Brookles C, Giacobbe F, D'Ascenzo F, Angelini F, Saglietto A, De Ferrari GM and Dusi V: The intrinsic cardiac nervous system: From pathophysiology to therapeutic implications. Biology (Basel). 13:1052024.PubMed/NCBI

Armour JA, Murphy DA, Yuan BX, Macdonald S and Hopkins DA: Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec. 247:289–298. 1997. View Article : Google Scholar : PubMed/NCBI

Wake E and Brack K: Characterization of the intrinsic cardiac nervous system. Auton Neurosci. 199:3–16. 2016. View Article : Google Scholar : PubMed/NCBI

Fedele L and Brand T: The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction. J Cardiovasc Dev Dis. 7:542020.PubMed/NCBI

Rysevaite K, Saburkina I, Pauziene N, Noujaim SF, Jalife J and Pauza DH: Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart. Heart Rhythm. 8:448–454. 2011. View Article : Google Scholar

Kimura K, Ieda M and Fukuda K: Development, maturation, and transdifferentiation of cardiac sympathetic nerves. Circ Res. 110:325–336. 2012. View Article : Google Scholar : PubMed/NCBI

Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Armour JA, Ardell JL and Shivkumar K: Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. J Physiol. 594:321–341. 2016. View Article : Google Scholar :

Gardner RT, Ripplinger CM, Myles RC and Habecker BA: Molecular mechanisms of sympathetic remodeling and arrhythmias. Circ Arrhythm Electrophysiol. 9:e0013592016. View Article : Google Scholar : PubMed/NCBI

Hopkins DA, Macdonald SE, Murphy DA and Armour JA: Pathology of intrinsic cardiac neurons from ischemic human hearts. Anat Rec. 259:424–436. 2000. View Article : Google Scholar : PubMed/NCBI

Hardwick JC, Ryan SE, Beaumont E, Ardell JL and Southerland EM: Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction. Auton Neurosci. 181:4–12. 2014. View Article : Google Scholar :

Vaseghi M, Salavatian S, Rajendran PS, Yagishita D, Woodward WR, Hamon D, Yamakawa K, Irie T, Habecker BA and Shivkumar K: Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction. JCI Insight. 2:e867152017. View Article : Google Scholar : PubMed/NCBI

Yperzeele L, van Hooff RJ, Nagels G, De Smedt A, De Keyser J and Brouns R: Heart rate variability and baroreceptor sensitivity in acute stroke: A systematic review. Int J Stroke. 10:796–800. 2015. View Article : Google Scholar : PubMed/NCBI

Grilletti JVF, Scapini KB, Bernardes N, Spadari J, Bigongiari A, Mazuchi FAES, Caperuto EC, Sanches IC, Rodrigues B and De Angelis K: Impaired baroreflex sensitivity and increased systolic blood pressure variability in chronic post-ischemic stroke. Clinics (Sao Paulo). 73:e2532018. View Article : Google Scholar : PubMed/NCBI

Chen Z, Venkat P, Seyfried D, Chopp M, Yan T and Chen J: Brain-heart interaction: Cardiac complications after stroke. Circ Res. 121:451–468. 2017. View Article : Google Scholar : PubMed/NCBI

Tang S, Xiong L, Fan Y, Mok VCT, Wong KS and Leung TW: Stroke outcome prediction by blood pressure variability, heart rate variability, and baroreflex sensitivity. Stroke. 51:1317–1320. 2020. View Article : Google Scholar : PubMed/NCBI

Aftyka J, Staszewski J, Dębiec A, Pogoda-Wesołowska A and Żebrowski J: Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review. Front Physiol. 14:11151642023. View Article : Google Scholar : PubMed/NCBI

Giunta S, Xia S, Pelliccioni G and Olivieri F: Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies. Geroscience. 46:113–127. 2024. View Article : Google Scholar :

Bruno RM, Ghiadoni L, Seravalle G, Dell'oro R, Taddei S and Grassi G: Sympathetic regulation of vascular function in health and disease. Front Physiol. 3:2842012. View Article : Google Scholar : PubMed/NCBI

Amiya E, Watanabe M and Komuro I: The relationship between vascular function and the autonomic nervous system. Ann Vasc Dis. 7:109–119. 2014. View Article : Google Scholar : PubMed/NCBI

He Z: The control mechanisms of heart rate dynamics in a new heart rate nonlinear time series model. Sci Rep. 10:48142020. View Article : Google Scholar : PubMed/NCBI

Valensi P: Autonomic nervous system activity changes in patients with hypertension and overweight: Role and therapeutic implications. Cardiovasc Diabetol. 20:1702021. View Article : Google Scholar : PubMed/NCBI

Monahan KD, Feehan RP, Sinoway LI and Gao Z: Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: Effect of ageing. J Physiol. 591:2937–2947. 2013. View Article : Google Scholar : PubMed/NCBI

Hoffman JIE and Buckberg GD: The myocardial oxygen supply: Demand index revisited. J Am Heart Assoc. 3:e0002852014. View Article : Google Scholar

Hartupee J and Mann DL: Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol. 14:30–38. 2017. View Article : Google Scholar :

Remme WJ: The sympathetic nervous system and ischaemic heart disease. Eur Heart J. 19(Suppl F): F62–F71. 1998.PubMed/NCBI

Szczepanska-Sadowska E: Neuromodulation of cardiac ischemic pain: Role of the autonomic nervous system and vasopressin. J Integr Neurosci. 23:492024. View Article : Google Scholar : PubMed/NCBI

Wu L, Tai Y, Hu S, Zhang M, Wang R, Zhou W, Tao J, Han Y, Wang Q and Wei W: Bidirectional role of β2-adrenergic receptor in autoimmune diseases. Front Pharmacol. 9:13132018. View Article : Google Scholar

Grisanti LA, Perez DM and Porter JE: Modulation of immune cell function by α(1)-adrenergic receptor activation. Curr Top Membr. 67:113–138. 2011. View Article : Google Scholar

Perez DM: α₁-Adrenergic receptors: insights into potential therapeutic opportunities for COVID-19, heart failure, and Alzheimer's disease. Int J Mol Sci. 24:41882023. View Article : Google Scholar

Kinugawa T, Kato M, Ogino K, Osaki S, Tomikura Y, Igawa O, Hisatome I and Shigemasa C: Interleukin-6 and tumor necrosis factor-alpha levels increase in response to maximal exercise in patients with chronic heart failure. Int J Cardiol. 87:83–90. 2003. View Article : Google Scholar

Li M, Yao W, Li S and Xi J: Norepinephrine induces the expression of interleukin-6 via β-adrenoreceptor-NAD(P)H oxidase system-NF-κB dependent signal pathway in U937 macrophages. Biochem Biophys Res Commun. 460:1029–1034. 2015. View Article : Google Scholar : PubMed/NCBI

Al-Sharea A, Lee MKS, Whillas A, Michell DL, Shihata WA, Nicholls AJ, Cooney OD, Kraakman MJ, Veiga CB, Jefferis AM, et al: Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis. Haematologica. 104:456–467. 2019. View Article : Google Scholar :

Stone PH, Libby P and Boden WE: Fundamental pathobiology of coronary atherosclerosis and clinical implications for chronic ischemic heart disease management-the plaque hypothesis: A narrative review. JAMA Cardiol. 8:192–201. 2023. View Article : Google Scholar

Wang Y, Anesi J, Maier MC, Myers MA, Oqueli E, Sobey CG, Drummond GR and Denton KM: Sympathetic nervous system and atherosclerosis. Int J Mol Sci. 24:131322023. View Article : Google Scholar : PubMed/NCBI

Chen YC, Smith M, Ying YL, Makridakis M, Noonan J, Kanellakis P, Rai A, Salim A, Murphy A, Bobik A, et al: Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization. Commun Biol. 6:2652023. View Article : Google Scholar : PubMed/NCBI

Apolloni S and D'Ambrosi N: Inflammation in the CNS and PNS: From molecular basis to therapy. Int J Mol Sci. 24:94172023. View Article : Google Scholar : PubMed/NCBI

Zanos S: Closed-loop neuromodulation in physiological and translational research. Cold Spring Harb Perspect Med. 9:a0343142019. View Article : Google Scholar

Ali R and Schwalb JM: History and future of spinal cord stimulation. Neurosurgery. 94:20–28. 2024.

Ferraro MC, Gibson W, Rice ASC, Vase L, Coyle D and O'Connell NE: Spinal cord stimulation for chronic pain. Lancet Neurol. 21:4052022. View Article : Google Scholar : PubMed/NCBI

Augustinsson LE, Linderoth B, Mannheimer C and Eliasson T: Spinal cord stimulation in cardiovascular disease. Neurosurg Clin N Am. 6:157–165. 1995. View Article : Google Scholar : PubMed/NCBI

Theofilis P, Oikonomou E, Sagris M, Papageorgiou N, Tsioufis K and Tousoulis D: Novel concepts in the management of angina in coronary artery disease. Curr Pharm Des. 29:1825–1834. 2023. View Article : Google Scholar : PubMed/NCBI

Greco S, Auriti A, Fiume D, Gazzeri G, Gentilucci G, Antonini L and Santini M: Spinal cord stimulation for the treatment of refractory angina pectoris: A two-year follow-up. Pacing Clin Electrophysiol. 22:26–32. 1999. View Article : Google Scholar : PubMed/NCBI

Jessurun GA, DeJongste MJ, Hautvast RW, Tio RA, Brouwer J, van Lelieveld S and Crijns HJ: Clinical follow-up after cessation of chronic electrical neuromodulation in patients with severe coronary artery disease: A prospective randomized controlled study on putative involvement of sympathetic activity. Pacing Clin Electrophysiol. 22:1432–1439. 1999. View Article : Google Scholar : PubMed/NCBI

Eddicks S, Maier-Hauff K, Schenk M, Müller A, Baumann G and Theres H: Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: The first placebo-controlled randomised study. Heart. 93:585–590. 2007. View Article : Google Scholar : PubMed/NCBI

de Jongste MJ, Hautvast RW, Hillege HL and Lie KI: Efficacy of spinal cord stimulation as adjuvant therapy for intractable angina pectoris: A prospective, randomized clinical study. Working group on neurocardiology. J Am Coll Cardiol. 23:1592–1597. 1994. View Article : Google Scholar : PubMed/NCBI

Hautvast RW, Blanksma PK, DeJongste MJ, Pruim J, van der Wall EE, Vaalburg W and Lie KI: Effect of spinal cord stimulation on myocardial blood flow assessed by positron emission tomography in patients with refractory angina pectoris. Am J Cardiol. 77:462–467. 1996. View Article : Google Scholar : PubMed/NCBI

Hautvast RW, DeJongste MJ, Staal MJ, van Gilst WH and Lie KI: Spinal cord stimulation in chronic intractable angina pectoris: A randomized, controlled efficacy study. Am Heart J. 136:1114–1120. 1998. View Article : Google Scholar : PubMed/NCBI

Vulink NC, Overgaauw DM, Jessurun GA, Tenvaarwerk IA, Kropmans TJ, van der Schans CP, Middel B, Staal MJ and Dejongste MJ: The effects of spinal cord stimulation on quality of life in patients with therapeutically chronic refractory angina pectoris. Neuromodulation. 2:33–40. 1999. View Article : Google Scholar : PubMed/NCBI

McNab D, Khan SN, Sharples LD, Ryan JY, Freeman C, Caine N, Tait S, Hardy I and Schofield PM: An open label, single-centre, randomized trial of spinal cord stimulation vs percutaneous myocardial laser revascularization in patients with refractory angina pectoris: The SPiRiT trial. Eur Heart J. 27:1048–1053. 2006. View Article : Google Scholar : PubMed/NCBI

Dyer MT, Goldsmith KA, Khan SN, Sharples LD, Freeman C, Hardy I, Buxton MJ and Schofield PM: Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: The SPiRiT trial. Trials. 9:402008. View Article : Google Scholar : PubMed/NCBI

Bondesson S, Pettersson T, Erdling A, Hallberg IR, Wackenfors A and Edvinsson L: Comparison of patients undergoing enhanced external counterpulsation and spinal cord stimulation for refractory angina pectoris. Coron Artery Dis. 19:627–634. 2008. View Article : Google Scholar : PubMed/NCBI

Andréll P, Yu W, Gersbach P, Gillberg L, Pehrsson K, Hardy I, Ståhle A, Andersen C and Mannheimer C: Long-term effects of spinal cord stimulation on angina symptoms and quality of life in patients with refractory angina pectoris-results from the European angina registry link study (EARL). Heart. 96:1132–1136. 2010. View Article : Google Scholar

Lanza GA, Grimaldi R, Greco S, Ghio S, Sarullo F, Zuin G, De Luca A, Allegri M, Di Pede F, Castagno D, et al: Spinal cord stimulation for the treatment of refractory angina pectoris: A multicenter randomized single-blind study (the SCS-ITA trial). Pain. 152:45–52. 2011. View Article : Google Scholar

Saraste A, Ukkonen H, Varis A, Vasankari T, Tunturi S, Taittonen M, Rautakorpi P, Luotolahti M, Airaksinen KE and Knuuti J: Effect of spinal cord stimulation on myocardial perfusion reserve in patients with refractory angina pectoris. Eur Heart J Cardiovasc Imaging. 16:449–455. 2015. View Article : Google Scholar

Latif OA, Nedeljkovic SS and Stevenson LW: Spinal cord stimulation for chronic intractable angina pectoris: A unified theory on its mechanism. Clin Cardiol. 24:533–541. 2001. View Article : Google Scholar : PubMed/NCBI

Southerland EM, Milhorn DM, Foreman RD, Linderoth B, DeJongste MJ, Armour JA, Subramanian V, Singh M, Singh K and Ardell JL: Preemptive, but not reactive, spinal cord stimulation mitigates transient ischemia-induced myocardial infarction via cardiac adrenergic neurons. Am J Physiol Heart Circ Physio. 292:H311–H327. 2007. View Article : Google Scholar

Dale EA, Kipke J, Kubo Y, Sunshine MD, Castro PA, Ardell JL and Mahajan A: Spinal cord neural network interactions: Implications for sympathetic control of the porcine heart. Am J Physiol Heart Circ Physiol. 318:H830–H839. 2020. View Article : Google Scholar : PubMed/NCBI

Salavatian S, Kuwabara Y, Wong B, Fritz JR, Howard-Quijano K, Foreman RD, Armour JA, Ardell JL and Mahajan A: Spinal neuromodulation mitigates myocardial ischemia-induced sympathoexcitation by suppressing the intermediolateral nucleus hyperactivity and spinal neural synchrony. Front Neurosci. 17:11802942023. View Article : Google Scholar : PubMed/NCBI

Saddic LA, Howard-Quijano K, Kipke J, Kubo Y, Dale EA, Hoover D, Shivkumar K, Eghbali M and Mahajan A: Progression of myocardial ischemia leads to unique changes in immediate-early gene expression in the spinal cord dorsal horn. Am J Physiol Heart Circ Physiol. 315:H1592–H1601. 2018. View Article : Google Scholar : PubMed/NCBI

Minisi AJ and Thames MD: Activation of cardiac sympathetic afferents during coronary occlusion. Evidence for reflex activation of sympathetic nervous system during transmural myocardial ischemia in the dog. Circulation. 84:357–367. 1991. View Article : Google Scholar : PubMed/NCBI

Ajijola OA and Shivkumar K: Neural remodeling and myocardial infarction: The stellate ganglion as a double agent. J Am Coll Cardiol. 59:962–964. 2012. View Article : Google Scholar : PubMed/NCBI

Ding X, Ardell JL, Hua F, McAuley RJ, Sutherly K, Daniel JJ and Williams CA: Modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive C2 spinal cord stimulation: Effect on substance P release from rat spinal cord. Am J Physiol Regul Integr Comp Physiol. 294:R93–R101. 2008. View Article : Google Scholar

Law M, Sachdeva R, Darrow D and Krassioukov A: Cardiovascular effects of spinal cord stimulation: The highs, the lows, and the don't knows. Neuromodulation. 27:1164–1176. 2024. View Article : Google Scholar

Tse HF, Turner S, Sanders P, Okuyama Y, Fujiu K, Cheung CW, Russo M, Green MDS, Yiu KH, Chen P, et al: Thoracic spinal cord stimulation for heart failure as a restorative treatment (SCS HEART study): First-in-man experience. Heart Rhythm. 12:588–595. 2015. View Article : Google Scholar

Wu M, Linderoth B and Foreman RD: Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: A review of experimental studies. Auton Neurosci. 138:9–23. 2008. View Article : Google Scholar

Gouveia FV, Warsi NM, Suresh H, Matin R and Ibrahim GM: Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation. Neurotherapeutics. 21:e003082024. View Article : Google Scholar : PubMed/NCBI

Austelle CW, O'Leary GH, Thompson S, Gruber E, Kahn A, Manett AJ, Short B and Badran BW: A comprehensive review of vagus nerve stimulation for depression. Neuromodulation. 25:309–315. 2022. View Article : Google Scholar : PubMed/NCBI

Gidron Y, Kupper N, Kwaijtaal M, Winter J and Denollet J: Vagus-brain communication in atherosclerosis-related inflammation: A neuroimmunomodulation perspective of CAD. Atherosclerosis. 195:e1–e9. 2007. View Article : Google Scholar

Giordano F, Zicca A, Barba C, Guerrini R and Genitori L: Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity. Epilepsia. 58(Suppl 1): S85–S90. 2017. View Article : Google Scholar

Winston GM, Guadix S, Lavieri MT, Uribe-Cardenas R, Kocharian G, Williams N, Sholle E, Grinspan Z and Hoffman CE: Closed-loop vagal nerve stimulation for intractable epilepsy: A single-center experience. Seizure. 88:95–101. 2021. View Article : Google Scholar : PubMed/NCBI

Skarpaas TL and Morrell MJ: Intracranial stimulation therapy for epilepsy. Neurotherapeutics. 6:238–243. 2009. View Article : Google Scholar : PubMed/NCBI

Sun FT and Morrell MJ: Closed-loop neurostimulation: The clinical experience. Neurotherapeutics. 11:553–563. 2014. View Article : Google Scholar : PubMed/NCBI

Ottaviani MM, Vallone F, Micera S and Recchia FA: Closed-loop vagus nerve stimulation for the treatment of cardiovascular diseases: State of the art and future directions. Front Cardiovasc Med. 9:8669572022. View Article : Google Scholar : PubMed/NCBI

Vilaine JP, Berdeaux A and Giudicelli JF: Effects of vagal stimulation on regional myocardial flows and ischemic injury in dogs. Eur J Pharmacol. 66:243–247. 1980. View Article : Google Scholar : PubMed/NCBI

Zuanetti G, De Ferrari GM, Priori SG and Schwartz PJ: Protective effect of vagal stimulation on reperfusion arrhythmias in cats. Circ Res. 61:429–435. 1987. View Article : Google Scholar : PubMed/NCBI

Rosenshtraukh L, Danilo P Jr, Anyukhovsky EP, Steinberg SF, Rybin V, Brittain-Valenti K, Molina-Viamonte V and Rosen MR: Mechanisms for vagal modulation of ventricular repolarization and of coronary occlusion-induced lethal arrhythmias in cats. Circ Res. 75:722–732. 1994. View Article : Google Scholar : PubMed/NCBI

Ando M, Katare RG, Kakinuma Y, Zhang D, Yamasaki F, Muramoto K and Sato T: Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein. Circulation. 112:164–170. 2005. View Article : Google Scholar : PubMed/NCBI

Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K and Sugimachi M: Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit. Am J Physiol Heart Circ Physiol. 293:H2254–H2261. 2007. View Article : Google Scholar : PubMed/NCBI

Del Rio CL, Dawson TA, Clymer BD, Paterson DJ and Billman GE: Effects of acute vagal nerve stimulation on the early passive electrical changes induced by myocardial ischaemia in dogs: Heart rate-mediated attenuation. Exp Physiol. 93:931–944. 2008. View Article : Google Scholar : PubMed/NCBI

Beaumont E, Southerland EM, Hardwick JC, Wright GL, Ryan S, Li Y, KenKnight BH, Armour JA and Ardell JL: Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol. 309:H1198–H1206. 2015. View Article : Google Scholar : PubMed/NCBI

Zamotrinsky A, Afanasiev S, Karpov RS and Cherniavsky A: Effects of electrostimulation of the vagus afferent endings in patients with coronary artery disease. Coron Artery Dis. 8:551–557. 1997.PubMed/NCBI

Zamotrinsky AV, Kondratiev B and de Jong JW: Vagal neurostimulation in patients with coronary artery disease. Auton Neurosci. 88:109–116. 2001. View Article : Google Scholar : PubMed/NCBI

Yu L, Huang B, Po SS, Tan T, Wang M, Zhou L, Meng G, Yuan S, Zhou X, Li X, et al: Low-level tragus stimulation for the treatment of ischemia and reperfusion injury in patients with ST-segment elevation myocardial infarction: A proof-of-concept study. JACC Cardiovasc Interv. 10:1511–1520. 2017. View Article : Google Scholar : PubMed/NCBI

Bonaz B, Sinniger V and Pellissier S: Anti-inflammatory properties of the vagus nerve: Potential therapeutic implications of vagus nerve stimulation. J Physiol. 594:5781–5790. 2016. View Article : Google Scholar : PubMed/NCBI

Li S, Qi D, Li JN, Deng XY and Wang DX: Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3. Cell Death Discovery. 7:632021. View Article : Google Scholar : PubMed/NCBI

Hachuła M, Kosowski M, Basiak M and Okopień B: Influence of dulaglutide on serum biomarkers of atherosclerotic plaque instability: An interventional analysis of cytokine profiles in diabetic subjects-a pilot study. Medicina (Kaunas). 60:9082024. View Article : Google Scholar

Shinlapawittayatorn K, Chinda K, Palee S, Surinkaew S, Thunsiri K, Weerateerangkul P, Chattipakorn S, KenKnight BH and Chattipakorn N: Low-amplitude, left vagus nerve stimulation significantly attenuates ventricular dysfunction and infarct size through prevention of mitochondrial dysfunction during acute ischemia-reperfusion injury. Heart Rhythm. 10:1700–1707. 2013. View Article : Google Scholar : PubMed/NCBI

Lu Y, Chen K, Zhao W, Hua Y, Bao S, Zhang J, Wu T, Ge G, Yu Y, Sun J and Zhang F: Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M₂AChR/OGDHL/ROS axis in rats. J Nanobiotechnology. 21:4212023. View Article : Google Scholar

Luo B, Wu Y, Liu SL, Li XY, Zhu HR, Zhang L, Zheng F, Liu XY, Guo LY, Wang L, et al: Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling. Cell Death Dis. 11:9712020. View Article : Google Scholar : PubMed/NCBI

Munhoz RP and Albuainain G: Deep brain stimulation: New programming algorithms and teleprogramming. Expert Rev Neurother. 23:467–478. 2023. View Article : Google Scholar : PubMed/NCBI

Lee DJ, Lozano CS, Dallapiazza RF and Lozano AM: Current and future directions of deep brain stimulation for neurological and psychiatric disorders. J Neurosurg. 131:333–342. 2019. View Article : Google Scholar : PubMed/NCBI

Basiago A and Binder DK: Effects of deep brain stimulation on autonomic function. Brain Sci. 6:332016. View Article : Google Scholar : PubMed/NCBI

Fontes MAP, Dos Santos Machado LR, Viana ACR, Cruz MH, Nogueira ÍS, Oliveira MGL, Neves CB, Godoy ACV, Henderson LA and Macefield VG: The insular cortex, autonomic asymmetry and cardiovascular control: Looking at the right side of stroke. Clin Auton Res. 34:549–560. 2024. View Article : Google Scholar : PubMed/NCBI

Hyam JA, Kringelbach ML, Silburn PA, Aziz TZ and Green AL: The autonomic effects of deep brain stimulation-a therapeutic opportunity. Nat Rev Neurol. 8:391–400. 2012. View Article : Google Scholar : PubMed/NCBI

Marins FR, Limborço-Filho M, Xavier CH, Biancardi VC, Vaz GC, Stern JE, Oppenheimer SM and Fontes MA: Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex. Clin Exp Pharmacol Physiol. 43:484–493. 2016. View Article : Google Scholar : PubMed/NCBI

Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler M, De Ferrari GM, Fishbein MC, Goldberger JJ, Harper RM, et al: Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. J Physiol. 594:3911–3954. 2016. View Article : Google Scholar : PubMed/NCBI

Sumi K, Katayama Y, Otaka T, Obuchi T, Kano T, Kobayashi K, Oshima H, Fukaya C, Yamamoto T, Ogawa Y and Iwasaki K: Effect of subthalamic nucleus deep brain stimulation on the autonomic nervous system in Parkinson's disease patients assessed by spectral analyses of R-R interval variability and blood pressure variability. Stereotact Funct Neurosurg. 90:248–254. 2012. View Article : Google Scholar : PubMed/NCBI

Zhang C, Xu J, Wu B, Ling Y, Guo Q, Wang S, Liu L, Jiang N, Chen L and Liu J: Subthalamic nucleus deep brain stimulation treats Parkinson's disease patients with cardiovascular disease comorbidity: A retrospective study of a single center experience. Brain Sci. 13:702022. View Article : Google Scholar

Rajkumar S, Venkatraman V, Yang LZ, Parente B, Lee HJ and Lad SP: Short-term health care costs of high-frequency spinal cord stimulation for the treatment of postsurgical persistent spinal pain syndrome. Neuromodulation. 26:1450–1458. 2023. View Article : Google Scholar : PubMed/NCBI

Kumar K, Caraway DL, Rizvi S and Bishop S: Current challenges in spinal cord stimulation. Neuromodulation. 17(Suppl 1): S22–S35. 2014. View Article : Google Scholar

Yap JYY, Keatch C, Lambert E, Woods W, Stoddart PR and Kameneva T: Critical review of transcutaneous vagus nerve stimulation: Challenges for translation to clinical practice. Front Neurosci. 14:2842020. View Article : Google Scholar : PubMed/NCBI

Austelle CW, Cox SS, Wills KE and Badran BW: Vagus nerve stimulation (VNS): Recent advances and future directions. Clin Auton Res. 34:529–547. 2024. View Article : Google Scholar : PubMed/NCBI

Javan-Noughabi J, Rezapour A, Hajahmadi M and Alipour V: Economic evaluation of single-photon emission-computed tomography versus stress echocardiography in stable chest pain patients. Sci Rep. 12:152232022. View Article : Google Scholar : PubMed/NCBI

Hijazi W, Vandenberk B, Rennert-May E, Quinn A, Sumner G and Chew DS: Economic evaluation in cardiac electrophysiology: Determining the value of emerging technologies. Front Cardiovasc Med. 10:11424292023. View Article : Google Scholar : PubMed/NCBI

Tabaja H, Yuen J, Tai DBG, Campioli CC, Chesdachai S, DeSimone DC, Hassan A, Klassen BT, Miller KJ, Lee KH and Mahmood M: Deep brain stimulator device infection: The mayo clinic rochester experience. Open Forum Infect Dis. 10:ofac6312022. View Article : Google Scholar

Jung IH, Chang KW, Park SH, Chang WS, Jung HH and Chang JW: Complications After deep brain stimulation: A 21-year experience in 426 patients. Front Aging Neurosci. 14:8197302022. View Article : Google Scholar : PubMed/NCBI

Olson MC, Shill H, Ponce F and Aslam S: Deep brain stimulation in PD: Risk of complications, morbidity, and hospitalizations: A systematic review. Front Aging Neurosci. 15:12581902023. View Article : Google Scholar : PubMed/NCBI

Lee JM, Lee D, Christiansen S, Hagedorn JM, Chen Z and Deer T: Spinal cord stimulation in special populations: Best practices from the american society of pain and neuroscience to improve safety and efficacy. J Pain Res. 15:3263–3273. 2022. View Article : Google Scholar : PubMed/NCBI

Ki YM, Park HJ, Yi SH, Sim WS and Lee JY: Latent infection after spinal cord stimulation device implantation for complex regional pain syndrome: A case report. Medicine (Baltimore). 102:e337502023. View Article : Google Scholar : PubMed/NCBI

Vu PD, Pinkhasova D, Sarwary ZB, Rita Markaryan A, Mousa B, Viswanath O, Robinson CL, Varrassi G, Orhurhu V, Urits I and Hasoon J: Biologic complications associated with cylindrical lead spinal cord stimulator implants: A narrative review. Orthop Rev (Pavia). 16:1234432024. View Article : Google Scholar : PubMed/NCBI

Das S, Matias CM, Ramesh S, Velagapudi L, Barbera JP, Katz S, Baldassari MP, Rasool M, Kremens D, Ratliff J, et al: Capturing initial understanding and impressions of surgical therapy for Parkinson's disease. Front Neurol. 12:6059592021. View Article : Google Scholar : PubMed/NCBI

Salinas M, Yazdani U, Oblack A, McDaniels B, Ahmed N, Haque B, Pouratian N and Chitnis S: Know DBS: Patient perceptions and knowledge of deep brain stimulation in Parkinson's disease. Ther Adv Neurol Disord. 17:175628642412330382024. View Article : Google Scholar : PubMed/NCBI

Müller O and Rotter S: Neurotechnology: Current developments and ethical issues. Front Syst Neurosci. 11:932017. View Article : Google Scholar

Faltus T, Freise J, Fluck C and Zillmann H: Ethics and regulation of neuronal optogenetics in the European Union. Pflugers Arch. 475:1505–1517. 2023. View Article : Google Scholar : PubMed/NCBI

Jog MA, Anderson C, Kubicki A, Boucher M, Leaver A, Hellemann G, Iacoboni M, Woods R and Narr K: Transcranial direct current stimulation (tDCS) in depression induces structural plasticity. Sci Rep. 13:28412023. View Article : Google Scholar : PubMed/NCBI

Lapa JDS, Duarte JFS, Campos ACP, Davidson B, Nestor SM, Rabin JS, Giacobbe P, Lipsman N and Hamani C: Adverse effects of deep brain stimulation for treatment-resistant depression: A scoping review. Neurosurgery. 95:509–516. 2024. View Article : Google Scholar : PubMed/NCBI

Siebner HR, Funke K, Aberra AS, Antal A, Bestmann S, Chen R, Classen J, Davare M, Di Lazzaro V, Fox PT, et al: Transcranial magnetic stimulation of the brain: What is stimulated?-A consensus and critical position paper. Clin Neurophysiol. 140:59–97. 2022. View Article : Google Scholar : PubMed/NCBI

Iseger TA, van Bueren NER, Kenemans JL, Gevirtz R and Arns M: A frontal-vagal network theory for major depressive disorder: Implications for optimizing neuromodulation techniques. Brain Stimul. 13:1–9. 2020. View Article : Google Scholar

Jiao Y, Cheng C, Jia M, Chu Z, Song X, Zhang M, Xu H, Zeng X, Sun JB, Qin W and Yang XJ: Neuro-cardiac-guided transcranial magnetic stimulation: Unveiling the modulatory effects of low-frequency and high-frequency stimulation on heart rate. Psychophysiology. 61:e146312024. View Article : Google Scholar : PubMed/NCBI

Zou N, Zhou Q, Zhang Y, Xin C, Wang Y, Claire-Marie R, Rong P, Gao G and Li S: Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: A review. Int J Surg. 110:4993–5006. 2024. View Article : Google Scholar : PubMed/NCBI

Afra P, Adamolekun B, Aydemir S and Watson GDR: Evolution of the vagus nerve stimulation (VNS) therapy system technology for drug-resistant epilepsy. Front Med Technol. 3:6965432021. View Article : Google Scholar

Habibagahi I, Omidbeigi M, Hadaya J, Lyu H, Jang J, Ardell JL, Bari AA and Babakhani A: Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs. Sci Rep. 12:81842022. View Article : Google Scholar : PubMed/NCBI

Mirza KB, Golden CT, Nikolic K and Toumazou C: Closed-loop implantable therapeutic neuromodulation systems based on neurochemical monitoring. Front Neurosci. 13:8082019. View Article : Google Scholar : PubMed/NCBI

de Faria GM, Lopes EG, Tobaldini E, Montano N, Cunha TS, Casali KR and de Amorim HA: Advances in non-invasive neuromodulation: Designing closed-loop devices for respiratory-controlled transcutaneous vagus nerve stimulation. Healthcare (Basel). 12:312023. View Article : Google Scholar

Van Horn JD, Grafton ST and Miller MB: Individual variability in brain activity: A nuisance or an opportunity? Brain Imaging Behav. 2:327–334. 2008. View Article : Google Scholar

Li LM, Uehara K and Hanakawa T: The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies. Front Cell Neurosci. 9:1812015. View Article : Google Scholar : PubMed/NCBI

Seghier ML and Price CJ: Interpreting and utilising intersubject variability in brain function. Trends Cogn Sci. 22:517–530. 2018. View Article : Google Scholar : PubMed/NCBI

Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, Holt A, Lim KO, Carey JR, Vitek JL and He B: Neuromodulation for brain disorders: Challenges and opportunities. IEEE Trans Biomed Eng. 60:610–624. 2013. View Article : Google Scholar : PubMed/NCBI

Völzke H, Schmidt CO, Baumeister SE, Ittermann T, Fung G, Krafczyk-Korth J, Hoffmann W, Schwab M, Meyer zu Schwabedissen HE, Dörr M, et al: Personalized cardiovascular medicine: Concepts and methodological considerations. Nat Rev Cardiol. 10:308–316. 2013. View Article : Google Scholar : PubMed/NCBI

Thompson N, Mastitskaya S and Holder D: Avoiding off-target effects in electrical stimulation of the cervical vagus nerve: Neuroanatomical tracing techniques to study fascicular anatomy of the vagus nerve. J Neurosci Methods. 325:1083252019. View Article : Google Scholar : PubMed/NCBI

Fitchett A, Mastitskaya S and Aristovich K: Selective neuromodulation of the vagus nerve. Front Neurosci. 15:6858722021. View Article : Google Scholar : PubMed/NCBI

Sclocco R, Garcia RG, Gabriel A, Kettner NW, Napadow V and Barbieri R: Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) effects on autonomic outflow in hypertension. Annu Int Conf IEEE Eng Med Biol Soc. 2017:3130–3133. 2017.PubMed/NCBI

Garcia RG, Cohen JE, Stanford AD, Gabriel A, Stowell J, Aizley H, Barbieri R, Gitlin D, Napadow V and Goldstein JM: Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) modulates brain response to stress in major depression. J Psychiatr Res. 142:188–197. 2021. View Article : Google Scholar : PubMed/NCBI

Cook DN, Thompson S, Stomberg-Firestein S, Bikson M, George MS, Jenkins DD and Badran BW: Design and validation of a closed-loop, motor-activated auricular vagus nerve stimulation (MAAVNS) system for neurorehabilitation. Brain Stimul. 13:800–803. 2020. View Article : Google Scholar : PubMed/NCBI

Badran BW, Peng X, Baker-Vogel B, Hutchison S, Finetto P, Rishe K, Fortune A, Kitchens E, O'Leary GH, Short A, et al: Motor activated auricular vagus nerve stimulation as a potential neuromodulation approach for post-stroke motor rehabilitation: A pilot study. Neurorehabil Neural Repair. 37:374–383. 2023. View Article : Google Scholar : PubMed/NCBI

Yu Y, Ling J, Yu L, Liu P and Jiang M: Closed-loop transcutaneous auricular vagal nerve stimulation: Current situation and future possibilities. Front Hum Neurosci. 15:7856202022. View Article : Google Scholar : PubMed/NCBI

Forrest IS, Petrazzini BO, Duffy Á, Park JK, Marquez-Luna C, Jordan DM, Rocheleau G, Cho JH, Rosenson RS, Narula J, et al: Machine learning-based marker for coronary artery disease: Derivation and validation in two longitudinal cohorts. Lancet. 401:215–225. 2023. View Article : Google Scholar :

Upton R, Mumith A, Beqiri A, Parker A, Hawkes W, Gao S, Porumb M, Sarwar R, Marques P, Markham D, et al: Automated echocardiographic detection of severe coronary artery disease using artificial intelligence. JACC Cardiovasc Imaging. 15:715–727. 2022. View Article : Google Scholar

Alizadehsani R, Abdar M, Roshanzamir M, Khosravi A, Kebria PM, Khozeimeh F, Nahavandi S, Sarrafzadegan N and Acharya UR: Machine learning-based coronary artery disease diagnosis: A comprehensive review. Comput Biol Med. 111:1033462019. View Article : Google Scholar : PubMed/NCBI

Obst MA, Al-Zubaidi A, Heldmann M, Nolde JM, Blümel N, Kannenberg S and Münte TF: Five weeks of intermittent transcutaneous vagus nerve stimulation shape neural networks: A machine learning approach. Brain Imaging Behav. 16:1217–1233. 2022. View Article : Google Scholar :

Tarasenko A, Guazzotti S, Minot T, Oganesyan M and Vysokov N: Determination of the effects of transcutaneous auricular vagus nerve stimulation on the heart rate variability using a machine learning pipeline. Bioelectricity. 4:168–177. 2022. View Article : Google Scholar : PubMed/NCBI

Chen H, Lai H, Chi H, Fan W, Huang J, Zhang S, Jiang C, Jiang L, Hu Q, Yan X, et al: Multi-modal transcriptomics: integrating machine learning and convolutional neural networks to identify immune biomarkers in atherosclerosis. Front Cardiovasc Med. 11:13974072024. View Article : Google Scholar : PubMed/NCBI