
m6A modification of non‑coding RNA: Mechanisms, functions and potential values in human diseases (Review)
- Authors:
- Qian Yi
- Yi Liao
- Wei Sun
- Jiachen Li
- Dahang Yang
- Hongxi Shang
- Weichao Sun
-
Affiliations: Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646099, P.R. China, Department of Technical Support, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, Jiangsu 530021, P.R. China, Department of Orthopedics, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China - Published online on: August 5, 2025 https://doi.org/10.3892/ijmm.2025.5605
- Article Number: 164
-
Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
![]() |
![]() |
![]() |
![]() |
Liang W, Yi H, Mao C, Meng Q, Wu X, Li S and Xue J: Research progress of RNA methylation modification in colorectal cancer. Front Pharmacol. 13:9036992022. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Jin H, Li Q, Shi L, Mao Y and Zhao L: The role of RNA methylation in tumor immunity and its potential in immunotherapy. Mol Cancer. 23:1302024. View Article : Google Scholar : PubMed/NCBI | |
Wen T, Li T, Xu Y, Zhang Y, Pan H and Wang Y: The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing. Cell Commun Signal. 21:3552023. View Article : Google Scholar : PubMed/NCBI | |
An Y and Duan H: The role of m6A RNA methylation in cancer metabolism. Mol Cancer. 21:142022. View Article : Google Scholar : PubMed/NCBI | |
Zhang Q and Xu K: The role of regulators of RNA m6A methylation in lung cancer. Genes Dis. 10:495–504. 2023. View Article : Google Scholar | |
Mendel M, Chen KM, Homolka D, Gos P, Pandey RR, McCarthy AA and Pillai RS: Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development. Mol Cell. 71:986–1000.e1011. 2018. View Article : Google Scholar | |
Ma H, Hong Y, Xu Z, Weng Z, Yang Y, Jin D, Chen Z, Yue J, Zhou X, Xu Z, et al: N6-methyladenosine (m6A) modification in hepatocellular carcinoma. Biomed Pharmacother. 173:1163652024. View Article : Google Scholar | |
Qu Y, Gao N, Zhang S, Gao L, He B, Wang C, Gong C, Shi Q, Li Z, Yang S and Xiao Y: Role of N6-methyladenosine RNA modification in cancer. MedComm (2020). 5:e7152024. View Article : Google Scholar : PubMed/NCBI | |
Guttman M and Rinn JL: Modular regulatory principles of large non-coding RNAs. Nature. 482:339–346. 2012. View Article : Google Scholar : PubMed/NCBI | |
Nemeth K, Bayraktar R, Ferracin M and Calin GA: Non-coding RNAs in disease: From mechanisms to therapeutics. Nat Rev Genet. 25:211–232. 2024. View Article : Google Scholar | |
Gao K, Li X, Ni J, Wu B, Guo J, Zhang R and Wu G: Non-coding RNAs in enzalutamide resistance of castration-resistant prostate cancer. Cancer Lett. 566:2162472023. View Article : Google Scholar : PubMed/NCBI | |
Kopp F and Mendell JT: Functional classification and experimental dissection of long noncoding RNAs. Cell. 172:393–407. 2018. View Article : Google Scholar : PubMed/NCBI | |
Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI | |
Zhou WY, Cai ZR, Liu J, Wang DS, Ju HQ and Xu RH: Circular RNA: Metabolism, functions and interactions with proteins. Mol Cancer. 19:1722020. View Article : Google Scholar : PubMed/NCBI | |
Ning K, Zhao J, Feng Z, Park SY, McFarlin S, Cheng F, Yan Z, Wang J and Qiu J: N6-methyladenosine modification of a parvovirus-encoded small noncoding RNA facilitates viral DNA replication through recruiting Y-family DNA polymerases. Proc Natl Acad Sci USA. 121:e23207821212024. View Article : Google Scholar : PubMed/NCBI | |
Garbo S, D'Andrea D, Colantoni A, Fiorentino F, Mai A, Ramos A, Tartaglia GG, Tancredi A, Tripodi M and Battistelli C: m6A modification inhibits miRNAs' intracellular function, favoring their extracellular export for intercellular communication. Cell Rep. 43:1143692024. View Article : Google Scholar : PubMed/NCBI | |
Duan JL, Chen W, Xie JJ, Zhang ML, Nie RC, Liang H, Mei J, Han K, Xiang ZC, Wang FW, et al: A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma. Mol Cancer. 21:932022. View Article : Google Scholar : PubMed/NCBI | |
Zhou J, Yao L, Su Y and Tian L: IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_ circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer. Chem Biol Drug Des. 103:e144732024. View Article : Google Scholar | |
Desrosiers R, Friderici K and Rottman F: Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA. 71:3971–3975. 1974. View Article : Google Scholar : PubMed/NCBI | |
Huang H, Weng H and Chen J: m6A modification in coding and non-coding RNAs: Roles and therapeutic implications in cancer. Cancer Cell. 37:270–288. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liang J, Yi Q, Liu Y, Li J, Yang Z and Sun W and Sun W: Recent advances of m6A methylation in skeletal system disease. J Transl Med. 22:1532024. View Article : Google Scholar : PubMed/NCBI | |
Qiao Y, Mei Y, Xia M, Luo D and Gao L: The role of m6A modification in the risk prediction and Notch1 pathway of Alzheimer's disease. iScience. 27:1102352024. View Article : Google Scholar : PubMed/NCBI | |
Zhu L, Zhang H, Zhang X and Xia L: RNA m6A methylation regulators in sepsis. Mol Cell Biochem. 479:2165–2180. 2024. View Article : Google Scholar | |
Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, et al: METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. J Clin Invest. 134:e1748472024. View Article : Google Scholar : PubMed/NCBI | |
Wu S, Wang H, Yang Q, Liu Z, Du J, Wang L, Chen S, Lu Q and Yang D: METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth. Cancer Lett. 597:2170582024. View Article : Google Scholar : PubMed/NCBI | |
Liu X, Feng M, Hao X, Gao Z, Wu Z, Wang Y, Du L and Wang C: m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop. Oncogene. 42:2047–2060. 2023. View Article : Google Scholar : PubMed/NCBI | |
Ning J, Yan J, Wang S, Cui Z, Xue Y, Juan J and Yang H: Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus. iScience. 27:1099002024. View Article : Google Scholar : PubMed/NCBI | |
Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, et al: m6A modification promotes EMT and metastasis of castration-resistant prostate cancer by upregulating NFIB. Cancer Res. 84:1947–1962. 2024. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Su T, Wu Y, Cai Y, Wang L, Liang C, Zhou L, Wang S, Li XX, Peng S, et al: N6-Methyladenosine reader YTHDF1 promotes stemness and therapeutic resistance in hepatocellular carcinoma by enhancing NOTCH1 expression. Cancer Res. 84:827–840. 2024. View Article : Google Scholar : PubMed/NCBI | |
Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L and Jiang P: m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage. Epigenetics. 19:23268682024. View Article : Google Scholar : PubMed/NCBI | |
Klein P, Howe MP, Harley J, Crook H, Serna SE, Roumeliotis TI, Choudhary JS, Chakrabarti AM, Luisier R, Patani R and Ramos A: m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation. Nat Commun. 15:48192024. View Article : Google Scholar : PubMed/NCBI | |
Xia T, Dai XY, Sang MY, Zhang X, Xu F, Wu J, Shi L, Wei JF and Ding Q: IGF2BP2 drives cell cycle progression in triple-negative breast cancer by recruiting EIF4A1 to promote the m6A-modified CDK6 translation initiation process. Adv Sci (Weinh). 11:e23051422024. View Article : Google Scholar | |
Lv L, Wei Q, Zhang J, Dong Y, Shan Z, Chang N, Zhao Y, Bian P and Yi Q: IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development. Cell Mol Biol Lett. 29:392024. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Lu X, Wang P, Chen Q, Xiong L, Tang M, Hong C, Lin X, Shi K, Liang L and Lin J: SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. J Transl Med. 20:1982022. View Article : Google Scholar : PubMed/NCBI | |
Shi S, Chen Q, Yang Y, Li Z, Zheng R, Zhang R, Liu Z and Cheng Y: HnRNPA2B1 promotes cardiac ferroptosis via m6A-dependent stabilization of PFN2 mRNA in myocardial ischemia-reperfusion injury. Free Radic Biol Med. 232:231–243. 2025. View Article : Google Scholar : PubMed/NCBI | |
Baek A, Lee GE, Golconda S, Rayhan A, Manganaris AA, Chen S, Tirumuru N, Yu H, Kim S, Kimmel C, et al: Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As. Nat Microbiol. 9:1340–1355. 2024. View Article : Google Scholar : PubMed/NCBI | |
McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY and Mason C: Single-molecule sequencing detection of N6-methyladenine in microbial reference materials. Nat Commun. 10:5792019. View Article : Google Scholar : PubMed/NCBI | |
Song M, Wang J, Hou J, Fu T, Feng Y, Lv W, Ge F, Peng R, Han D and Tan W: Multiplexed in situ imaging of site-specific m6A methylation with proximity hybridization followed by primer exchange amplification (m6A-PHPEA). ACS Nano. 18:27537–27546. 2024. View Article : Google Scholar : PubMed/NCBI | |
Zhang Q, Dai Y, Teng X and Li J: Visualization and quantification of single-Base m6A methylation. Angew Chem Int Ed Engl. 64:e2024209772025. View Article : Google Scholar | |
Yi Q, Xie W, Sun W, Sun W and Liao Y: A concise review of MicroRNA-383: Exploring the insights of its function in tumorigenesis. J Cancer. 13:313–324. 2022. View Article : Google Scholar : PubMed/NCBI | |
Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yi Q, Cui H, Liao Y, Xiong J, Ye X and Sun W: A minor review of microRNA-338 exploring the insights of its function in tumorigenesis. Biomed Pharmacother. 139:1117202021. View Article : Google Scholar : PubMed/NCBI | |
Valadkhan S: snRNAs as the catalysts of pre-mRNA splicing. Curr Opin Chem Biol. 9:603–608. 2005. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Liu X, Lin C, Jia X, Zhu H, Song J and Zhang Y: Noncoding RNAs regulate alternative splicing in cancer. J Exp Clin Cancer Res. 40:112021. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Hong R, Chen W, Xu M and Wang L: The role of long noncoding RNA in major human disease. Bioorg Chem. 92:1032142019. View Article : Google Scholar : PubMed/NCBI | |
Statello L, Guo CJ, Chen LL and Huarte M: Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 22:96–118. 2021. View Article : Google Scholar | |
Wu H, Yang L and Chen LL: The diversity of long noncoding RNAs and their generation. Trends Genet. 33:540–552. 2017. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Ding W, Yu W, Zhang Y, Ao X and Wang J: Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer. Mol Ther Oncolytics. 23:458–476. 2021. View Article : Google Scholar : PubMed/NCBI | |
Sengupta P, Roy A, Roy L, Bose D, Halder S, Jana K, Mukherjee G and Chatterjee S: Long non-coding intergenic RNA, LINC00273 induces cancer metastasis and stemness via miRNA sponging in triple negative breast cancer. Int J Biol Macromol. 274:1327302024. View Article : Google Scholar : PubMed/NCBI | |
Yao ZT, Yang YM, Sun MM, He Y, Liao L, Chen KS and Li B: New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer. Cancer Commun (Lond). 42:117–140. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, Weng H, Su R, Tan B, Shen C, et al: RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression. Genes Dis. 11:382–396. 2024. View Article : Google Scholar | |
Liu CX and Chen LL: Circular RNAs: Characterization, cellular roles, and applications. Cell. 185:2016–2034. 2022. View Article : Google Scholar : PubMed/NCBI | |
Chen LL: The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 17:205–211. 2016. View Article : Google Scholar : PubMed/NCBI | |
Yi Q, Feng J, Liao Y and Sun W: Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application. IUBMB Life. 75:225–237. 2023. View Article : Google Scholar | |
Conn VM, Chinnaiyan AM and Conn SJ: Circular RNA in cancer. Nat Rev Cancer. 24:597–613. 2024. View Article : Google Scholar : PubMed/NCBI | |
Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 20:675–691. 2019. View Article : Google Scholar : PubMed/NCBI | |
Dayal S, Chaubey D, Joshi DC, Ranmale S and Pillai B: Noncoding RNAs: Emerging regulators of behavioral complexity. Wiley Interdiscip Rev RNA. 15:e18472024. View Article : Google Scholar : PubMed/NCBI | |
Yi Q, Feng J, Lan W, Shi H and Sun W and Sun W: CircRNA and lncRNA-encoded peptide in diseases, an update review. Mol Cancer. 23:2142024. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Wang Z, Yang J, Sun Y, He Y, Wang Y, Chen X, Liang Y, Zhang N, Wang X, et al: CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation. Mol Cancer. 23:1022024. View Article : Google Scholar : PubMed/NCBI | |
Alarcón CR, Lee H, Goodarzi H, Halberg N and Tavazoie SF: N6-methyladenosine marks primary microRNAs for processing. Nature. 519:482–485. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H and Chen K: METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m6A-dependent manner. Aging Cell. 23:e141232024. View Article : Google Scholar | |
Chen P, Li S, Zhang K, Zhao R, Cui J, Zhou W, Liu Y, Zhang L and Cheng Y: N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression. Oncogene. 40:5600–5612. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ding D, Shang W, Shi K, Ying J, Wang L, Chen Z and Zhang C: FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis. BMC Cancer. 24:12702024. View Article : Google Scholar : PubMed/NCBI | |
Hou Y, Zhang Q, Pang W, Hou L, Liang Y, Han X, Luo X, Wang P, Zhang X, Li L and Meng X: YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect. Cell Death Differ. 28:3105–3124. 2021. View Article : Google Scholar : PubMed/NCBI | |
Bian Y, Xu S, Gao Z, Ding J, Li C, Cui Z, Sun H, Li J, Pu J and Wang K: m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/FOXM1 positive feedback loop. Cancer Lett. 596:2170042024. View Article : Google Scholar | |
Zhao K, Chen L, Xie Y, Ren N, Li J, Zhai X, Zheng S, Liu K, Wang C, Qiu Q, et al: m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways. Cancer Lett. 587:2167352024. View Article : Google Scholar : PubMed/NCBI | |
Shi Q, Li Z, Dong Y, Yang G and Li M: LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells. Int Immunopharmacol. 123:1107402023. View Article : Google Scholar : PubMed/NCBI | |
Lin Z, Huang Z, Qiu J, Shi Y, Zuo D, Qiu Z, He W, Niu Y, Yuan Y and Li B: m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma. J Exp Clin Cancer Res. 43:2062024. View Article : Google Scholar | |
Yang N, Yan N, Bai Z, Du S, Zhang J, Zhang L and Zhang Z: FTO attenuates LPS-induced acute kidney injury by inhibiting autophagy via regulating SNHG14/miR-373-3p/ATG7 axis. Int Immunopharmacol. 128:1114832024. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Liu X, Wang Y, Lai S, Wang Z, Yang Y, Liu W, Wang H and Tang B: The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway. Mol Cancer. 21:1742022. View Article : Google Scholar | |
Chen S, Duan X, He Y and Chen W: METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN. Biosci Rep. 44:BSR202311862024. View Article : Google Scholar : PubMed/NCBI | |
Fan HN, Chen ZY, Chen XY, Chen M, Yi YC, Zhu JS and Zhang J: METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis. Mol Cancer. 21:512022. View Article : Google Scholar | |
Du X, Shi L, Wang B and Zhang G: WTAP mediated m6A-modified circ_0056856 contributes to the proliferation, migration, and invasion of IL-22-stimulated human keratinocyte by miR-197-3p/CDK1 axis. Arch Dermatol Res. 316:2082024. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Ling Z, Cai X, Xu Y, Lv Z, Man D, Ge J, Yu C, Zhang D, Zhang Y, et al: Activation of YAP1 by N6-methyladenosine-modified circCPSF6 drives malignancy in hepatocellular carcinoma. Cancer Res. 82:599–614. 2022. View Article : Google Scholar | |
Zhu X and Zhang P: m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay. J Transl Med. 22:9312024. View Article : Google Scholar : PubMed/NCBI | |
Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, et al: Fat mass and obesity-associated protein (FTO) mediated m6A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. Mol Biomed. 5:112024. View Article : Google Scholar | |
Kong Z, Lu Y, Yang Y, Chang K, Lin Y, Huang Y, Wang C, Zhang L, Xu W, Zhao S and Li Y: m6A-mediated biogenesis of circDDIT4 inhibits prostate cancer progression by sequestrating ELAVL1/HuR. Mol Cancer Res. 21:1342–1355. 2023. View Article : Google Scholar : | |
Xu Y, Weng X, Qiu J and Wang S: Biogenesis of circRBM33 mediated by N6-methyladenosine and its function in abdominal aortic aneurysm. Epigenetics. 19:23924012024. View Article : Google Scholar : PubMed/NCBI | |
Wei Y, Fu J, Zhang H, Ling Y, Tang X, Liu S, Yu M, Liu F, Zhuang G, Qian H, et al: N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes. iScience. 26:1080222023. View Article : Google Scholar : PubMed/NCBI | |
Rao X, Lai L, Li X, Wang L, Li A and Yang Q: N6-methyladenosine modification of circular RNA circ-ARL3 facilitates Hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305. IUBMB Life. 73:408–417. 2021. View Article : Google Scholar | |
Liu Z, Wang T, She Y, Wu K, Gu S, Li L, Dong C, Chen C and Zhou Y: N6-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 20:1052021. View Article : Google Scholar | |
Dattilo D, Di Timoteo G, Setti A, Giuliani A, Peruzzi G, Nebot MB, Centrón-Broco A, Mariani D, Mozzetta C and Bozzoni I: The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs. Nat Commun. 14:18982023. View Article : Google Scholar | |
Wu X, Fu M, Ge C, Zhou H, Huang H, Zhong M, Zhang M, Xu H, Zhu G, Hua W, et al: m(6)A-mediated upregulation of lncRNA CHASERR promotes the progression of glioma by modulating the miR-6893-3p/TRIM14 axis. Mol Neurobiol. 61:5418–5440. 2024. View Article : Google Scholar : PubMed/NCBI | |
Wu W, Li X, Zhou Z, He H, Pang C, Ye S and Quan JH: METTL14 regulates inflammation in ulcerative colitis via the lncRNA DHRS4-AS1/miR-206/A3AR axis. Cell Biol Toxicol. 40:952024. View Article : Google Scholar : PubMed/NCBI | |
Liu P, Zhang B, Chen Z, He Y, Du Y, Liu Y and Chen X: m6A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway. Aging (Albany NY). 12:5280–5299. 2020. View Article : Google Scholar : PubMed/NCBI | |
Yu H and Zhang Z: ALKBH5-mediated m6A demethylation of lncRNA RMRP plays an oncogenic role in lung adenocarcinoma. Mamm Genome. 32:195–203. 2021. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Liang J, Dai X, Peng Y, Xiong W, Zhang L, Li X, Li W, Liu K, Bi S, et al: Transcriptome-wide N6-methyladenosine (m6A) methylation profiling of long non-coding RNAs in ovarian endometriosis. Genomics. 116:1108032024. View Article : Google Scholar : PubMed/NCBI | |
Yin H, Chen L, Piao S, Wang Y, Li Z, Lin Y, Tang X, Zhang H, Zhang H and Wang X: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway. Cell Death Differ. 30:605–617. 2023. View Article : Google Scholar : | |
Chang M, Cui X, Sun Q, Wang Y, Liu J, Sun Z, Ren J, Sun Y, Han L and Li W: Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21. Cancer Lett. 588:2167462024. View Article : Google Scholar : PubMed/NCBI | |
Xie R, Liu L, Lu X, He C, Yao H and Li G: N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation. Gastric Cancer. 27:49–71. 2024. View Article : Google Scholar : | |
Luo XJ, Lu YX, Wang Y, Huang R, Liu J, Jin Y, Liu ZK, Liu ZX, Huang QT, Pu H, et al: M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1. Cancer Lett. 598:2170852024. View Article : Google Scholar : PubMed/NCBI | |
Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L and Zhang Y: LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2. Clin Transl Med. 14:e17772024. View Article : Google Scholar : PubMed/NCBI | |
Yao L, Li T, Teng Y, Guo J, Zhang H, Xia L and Wu Q: ALKHB5-demethylated lncRNA SNHG15 promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier SETD2. Am J Physiol Cell Physiol. 326:C684–C697. 2024. View Article : Google Scholar : | |
Fang D, Ou X, Sun K, Zhou X, Li Y, Shi P, Zhao Z, He Y, Peng J and Xu J: m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability. Cancer Sci. 113:4135–4150. 2022. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Zhang J, Liu H, Meng L, Gao X, Zhao Y, Wang C, Gao X, Fan A, Cao T, et al: N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. Cancer Commun (Lond). 44:469–490. 2024. View Article : Google Scholar : PubMed/NCBI | |
Yi J, Ma X, Ying Y, Liu Z, Tang Y, Shu X, Sun J, Wu Y, Lu D, Wang X, et al: N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis. Cancer Lett. 585:2166132024. View Article : Google Scholar : PubMed/NCBI | |
Xu C, Zhou J, Zhang X, Kang X, Liu S, Song M, Chang C, Lin Y and Wang Y: N(6)-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges. Cell Mol Biol Lett. 29:282024. View Article : Google Scholar | |
Li H, Lin R, Zhang Y, Zhu Y, Huang S, Lan J, Lu N, Xie C, He S and Zhang W: N6-methyladenosine-modified circPLPP4 sustains cisplatin resistance in ovarian cancer cells via PIK3R1 upregulation. Mol Cancer. 23:52024. View Article : Google Scholar : PubMed/NCBI | |
Jiang S, Gao L, Li J, Zhang F, Zhang Y and Liu J: N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair. Front Cell Dev Biol. 12:13832322024. View Article : Google Scholar : PubMed/NCBI | |
Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, et al: N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1. J Exp Clin Cancer Res. 43:1192024. View Article : Google Scholar : PubMed/NCBI | |
Zhu X, Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Xing J, Zhang M, Zhao S, et al: M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis. J Nanobiotechnology. 22:3672024. View Article : Google Scholar | |
Li L, Chen J, Wang A and Yi K: ALKBH5 regulates ovarian cancer growth via demethylating long noncoding RNA PVT1 in ovarian cancer. J Cell Mol Med. 28:e180662024. View Article : Google Scholar : | |
Shen W, Pu J, Zuo Z, Gu S, Sun J, Tan B, Wang L, Cheng J and Zuo Y: The RNA demethylase ALKBH5 promotes the progression and angiogenesis of lung cancer by regulating the stability of the LncRNA PVT1. Cancer Cell Int. 22:3532022. View Article : Google Scholar : PubMed/NCBI | |
Li K, Gong Q, Xiang XD, Guo G, Liu J, Zhao L, Li J, Chen N, Li H, Zhang LJ, et al: HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis. J Transl Med. 21:3822023. View Article : Google Scholar | |
Dong F, Qin X, Wang B, Li Q, Hu J, Cheng X, Guo D, Cheng F, Fang C, Tan Y, et al: ALKBH5 facilitates hypoxia-induced paraspeckle assembly and IL8 secretion to generate an immunosuppressive tumor microenvironment. Cancer Res. 81:5876–5888. 2021. View Article : Google Scholar : PubMed/NCBI | |
Hu J, Duan H, Zou J, Ding W, Wei Z, Peng Q, Li Z, Duan R, Sun J and Zhu J: METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes. Aging (Albany NY). 16:299–321. 2024.PubMed/NCBI | |
Chang YZ, Chai RC, Pang B, Chang X, An SY, Zhang KN, Jiang T and Wang YZ: METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma. Cancer Lett. 511:36–46. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Xu Y, Qiu G, Luo Y, Bao Y, Lu J, Wang T and Wang Y: METTL3 mediated MALAT1 m6A modification promotes proliferation and metastasis in osteosarcoma cells. Mol Biotechnol. 66:3538–3548. 2024. View Article : Google Scholar | |
Han L, Lei G, Chen Z, Zhang Y, Huang C and Chen W: IGF2BP2 regulates MALAT1 by serving as an N6-methyladenosine reader to promote NSCLC proliferation. Front Mol Biosci. 8:7800892021. View Article : Google Scholar | |
Lu S, Han L, Hu X, Sun T, Xu D, Li Y, Chen Q, Yao W, He M, Wang Z, et al: N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: Implication in colorectal cancer. J Hematol Oncol. 14:1882021. View Article : Google Scholar : PubMed/NCBI | |
Peng J, Zheng H, Liu F, Wu Q and Liu S: The m6A methyltransferase METTL3 affects autophagy and progression of nasopharyngeal carcinoma by regulating the stability of lncRNA ZFAS1. Infect Agent Cancer. 17:12022. View Article : Google Scholar : PubMed/NCBI | |
Zhou X, Yang Y, Li Y, Liang G, Kang D, Zhou B and Li Q: METTL3 contributes to osteosarcoma progression by increasing DANCR mRNA stability via m6A modification. Front Cell Dev Biol. 9:7847192021. View Article : Google Scholar | |
Hu X, Peng WX, Zhou H, Jiang J, Zhou X, Huang D, Mo YY and Yang L: IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death Differ. 27:1782–1794. 2020. View Article : Google Scholar : | |
Wu S, Chi C, Weng S, Zhou W and Liu Z: IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia. Apoptosis. 28:1035–1047. 2023. View Article : Google Scholar : PubMed/NCBI | |
Rong D, Dong Q, Qu H, Deng X, Gao F, Li Q and Sun P: m(6) A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis. Cell Death Discov. 7:272021. View Article : Google Scholar | |
Zuo X, Chen Z, Gao W, Zhang Y, Wang J, Wang J, Cao M, Cai J, Wu J and Wang X: M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. J Hematol Oncol. 13:52020. View Article : Google Scholar : PubMed/NCBI | |
Yang D, Chang S, Li F, Ma M, Yang J, Lv X, Huangfu L and Jia C: m6 A transferase KIAA1429-stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1. IUBMB Life. 73:1325–1333. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhuang S, Ma Y, Zeng Y, Lu C, Yang F, Jiang N, Ge J, Ju H, Zhong C, Wang J, et al: METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis. Cell Biol Toxicol. 39:1015–1035. 2023. View Article : Google Scholar | |
Zhou Z, Cao Y, Yang Y, Wang S and Chen F: METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis. Epigenetics. 18:22170332023. View Article : Google Scholar | |
Li Y, Yan B, Wang X, Li Q, Kan X, Wang J, Sun Y, Wang P, Tian L and Liu M: ALKBH5-mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9. J Cell Mol Med. 26:385–398. 2022. View Article : Google Scholar | |
Ji F, Lu Y, Chen S, Lin X, Yu Y, Zhu Y and Luo X: m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer. Mol Ther Oncolytics. 22:574–581. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ren Z, Hu Y, Sun J, Kang Y, Li G and Zhao H: N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m(6)A/FOXM1 axis. Bioengineered. 13:7963–7973. 2022. View Article : Google Scholar : PubMed/NCBI | |
Lang C, Yin C, Lin K, Li Y, Yang Q, Wu Z, Du H, Ren D, Dai Y and Peng X: m6 A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization. Clin Transl Med. 11:e4262021. View Article : Google Scholar | |
Liu HT, Zou YX, Zhu WJ, Sen-Liu, Zhang GH, Ma RR, Guo XY and Gao P: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. Cell Death Differ. 29:627–641. 2022. View Article : Google Scholar : | |
Zheng Y, Wang Y, Liu Y, Xie L, Ge J, Yu G and Zhao G: N6-methyladenosine modification of PTTG3P contributes to colorectal cancer proliferation via YAP1. Front Oncol. 11:6697312021. View Article : Google Scholar : PubMed/NCBI | |
Huang T, Cao L, Feng N, Xu B, Dong Y and Wang M: N6-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop. Bioengineered. 12:10935–10944. 2021. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Qin S, Liu C, Jiang L, Li C, Yang J, Zhang S, Yan Z, Liu X, Yang J and Sun X: m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability. Cell Death Discov. 7:2922021. View Article : Google Scholar | |
Xue L, Li J, Lin Y, Liu D, Yang Q, Jian J and Peng J: m6 A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer. J Cell Physiol. 236:2649–2658. 2021. View Article : Google Scholar | |
Wu P, Fang X, Liu Y, Tang Y, Wang W, Li X and Fan Y: N6-methyladenosine modification of circCUX1 confers radio-resistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. Cell Death Dis. 12:2982021. View Article : Google Scholar | |
Ji F, Lu Y, Chen S, Yu Y, Lin X, Zhu Y and Luo X: IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m(6)A/FOXM1 manner. Cell Death Discov. 7:2152021. View Article : Google Scholar : PubMed/NCBI | |
Cheng X, Yang H, Chen Y, Zeng Z, Liu Y, Zhou X, Zhang C, Xie A and Wang G: METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy. Cell Mol Biol Lett. 29:1092024. View Article : Google Scholar | |
Wu Q, Yin X, Zhao W, Xu W and Chen L: Molecular mechanism of m6A methylation of circDLC1 mediated by RNA methyltransferase METTL3 in the malignant proliferation of glioma cells. Cell Death Discov. 8:2292022. View Article : Google Scholar | |
Shu X, Yi J, Li J, Ying Y, Tang Y, Chen Z, Wang J, Zhang F, Lu D, Wu Y, et al: N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis. Cell Signal. 125:1115102025. View Article : Google Scholar | |
Tian Q, Mu Q, Liu S, Huang K, Tang Y, Zhang P, Zhao J and Shu C: m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis. Carcinogenesis. 44:859–870. 2023. View Article : Google Scholar : PubMed/NCBI | |
Wu G, Hou Q, Liu Z, Pu Z and Wu L: N6-methyladenosine-modified circ_0006168 promotes epithelial mesenchymal transition via miR-384/STAT3/Snail axis in esophageal squamous cell carcinoma. J Cancer. 15:4939–4954. 2024. View Article : Google Scholar : | |
Zhang Y, Yang H, Long Y, Zhang Y, Chen R, Shi J and Chen J: circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion. Sci Rep. 11:243572021. View Article : Google Scholar : PubMed/NCBI | |
Liang L, Zhu Y, Li J, Zeng J and Wu L: ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription. J Exp Clin Cancer Res. 41:2612022. View Article : Google Scholar : PubMed/NCBI | |
Huang R, Sun M, Wang W, Yu X and Liu F: YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation. J Neuroimmunol. 387:5782652024. View Article : Google Scholar | |
Shao Y, Liu Z, Song X, Sun R, Zhou Y, Zhang D, Sun H, Huang J, Wu C, Gu W, et al: ALKBH5/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation. Clin Transl Med. 13:e13182023. View Article : Google Scholar : PubMed/NCBI | |
Wang D, Guan H and Xia Y: YTHDC1 maintains trophoblasts function by promoting degradation of m6A-modified circMPP1. Biochem Pharmacol. 210:1154562023. View Article : Google Scholar : PubMed/NCBI | |
Yu J, Li W, Hou GJ, Sun DP, Yang Y, Yuan SX, Dai ZH, Yin HZ, Sun SH, Huang G, et al: Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation. Exp Mol Med. 55:2390–2401. 2023. View Article : Google Scholar : PubMed/NCBI | |
Chen X, Zhu S, Li HD, Wang JN, Sun LJ, Xu JJ, Hui YR, Li XF, Li LY, Zhao YX, et al: N(6)-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation. Int J Biol Macromol. 248:1258112023. View Article : Google Scholar : PubMed/NCBI | |
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, et al: N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 10:46952019. View Article : Google Scholar | |
Ding P, Wu H, Wu J, Li T, He J, Ju Y, Liu Y, Li F, Deng H, Gu R, et al: N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer. Oncogene. 43:2548–2563. 2024. View Article : Google Scholar | |
Zhou M, Liu Y, Xu H, Chen X, Zheng N, Duan Z, Ge Y, Li D, Lin T, Zeng R, et al: YTHDC1-Modified m6A methylation of Hsa_circ_0102678 promotes keratinocyte inflammation induced by cutibacterium acnes biofilm through regulating miR-146a/TRAF6 and IRAK1 axis. J Innate Immun. 15:822–835. 2023. View Article : Google Scholar : PubMed/NCBI | |
Zeng W, Zhu JF, Guo J, Huang GJ, Ai LS, Zeng Y and Liao WJ: m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation. Cell Death Dis. 13:10082022. View Article : Google Scholar | |
Lin H, Cui Z, Tiange E, Xu H, Wang D, Wang P, Ruan X, Liu L and Xue Y: M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops. Cell Death Dis. 15:5542024. View Article : Google Scholar : PubMed/NCBI | |
Song M, Yao H, Sun Z, Chen D, Xu X, Long G, Wu L and Hu W: METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis. Cell Mol Biol Lett. 28:1012023. View Article : Google Scholar : PubMed/NCBI | |
Rong D, Wu F, Lu C, Sun G, Shi X, Chen X, Dai Y, Zhong W, Hao X, Zhou J, et al: m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression. Mol Ther Nucleic Acids. 26:637–648. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhang R, Yang R, Huang Z, Xu X, Lv S, Guan X, Li H and Wu J: METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression. Heliyon. 9:e225952023. View Article : Google Scholar : PubMed/NCBI | |
Ouyang L, Sun MM, Zhou PS, Ren YW, Liu XY, Wei WY, Song ZS, Lu K and Yang LX: LncRNA FOXD1-AS1 regulates pancreatic cancer stem cell properties and 5-FU resistance by regulating the miR-570-3p/SPP1 axis as a ceRNA. Cancer Cell Int. 24:42024. View Article : Google Scholar : PubMed/NCBI | |
Shu G, Zhao Z, Zhao T, Deng C, Zhu J, Han Y, Chen M, Jing J, Bai G, Li D, et al: N(6)-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor. J Exp Clin Cancer Res. 43:1912024. View Article : Google Scholar : PubMed/NCBI | |
Li H, Tang Y, Ruan X, Zhang J, Liu H, Yu S, Chen H, Yang H, Zhang K and Chen K: N6-methyladenosine-modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis. Clin Transl Med. 14:e16582024. View Article : Google Scholar : PubMed/NCBI | |
Zheng Z, Zeng X, Zhu Y, Leng M, Zhang Z, Wang Q, Liu X, Zeng S, Xiao Y, Hu C, et al: CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis. Mol Cancer. 23:42024. View Article : Google Scholar : PubMed/NCBI | |
Li J, Cao H, Yang J and Wang B: IGF2BP2-m6A-circMMP9 axis recruits ETS1 to promote TRIM59 transcription in laryngeal squamous cell carcinoma. Sci Rep. 14:30142024. View Article : Google Scholar : PubMed/NCBI | |
Mamontova V, Trifault B, Gribling-Burrer AS, Bohn P, Boten L, Preckwinkel P, Gallant P, Solvie D, Ade CP, Papadopoulos D, et al: NEAT1 promotes genome stability via m(6)A methylation-dependent regulation of CHD4. Genes Dev. 38:915–930. 2024. View Article : Google Scholar : PubMed/NCBI | |
Jiang T, Qi J, Xue Z, Liu B, Liu J, Hu Q, Li Y, Ren J, Song H, Xu Y, et al: The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN. Mol Cancer. 23:552024. View Article : Google Scholar | |
Olazagoitia-Garmendia A, Rojas-Márquez H, SebastiandelaCruz M, Agirre-Lizaso A, Ochoa A, Mendoza-Gomez LM, Perugorria MJ, Bujanda L, Madrigal AH, Santin I and Castellanos-Rubio A: m6A methylated long noncoding RNA LOC339803 regulates intestinal inflammatory response. Adv Sci (Weinh). 11:e23079282024. View Article : Google Scholar | |
Vaid R, Thombare K, Mendez A, Burgos-Panadero R, Djos A, Jachimowicz D, Lundberg KI, Bartenhagen C, Kumar N, Tümmler C, et al: METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: A therapeutic target for ALT-positive neuroblastoma. Nucleic Acids Res. 52:2648–2671. 2024. View Article : Google Scholar : PubMed/NCBI | |
Liu R, Zhong Y, Chen R, Chu C, Liu G, Zhou Y, Huang Y, Fang Z and Liu H: m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease. Theranostics. 12:7760–7774. 2022. View Article : Google Scholar : | |
Hu Z, Chen G, Zhao Y, Gao H, Li L, Yin Y, Jiang J, Wang L, Mang Y, Gao Y, et al: Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. Mol Cancer. 22:552023. View Article : Google Scholar | |
Yu J, Gao Y, Liu F, Zhang Y, Li J, Ding L, Ren S, Yang J, Jiao J, Feng G, et al: m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia. J Nanobiotechnology. 22:6542024. View Article : Google Scholar | |
Wang Z, He J, Bach DH, Huang YH, Li Z, Liu H, Lin P and Yang J: Induction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance. J Exp Clin Cancer Res. 41:42022. View Article : Google Scholar | |
Chen J, Zhou Y, Wu M, Yuan Y and Wu W: m6A modification mediates exosomal LINC00657 to trigger breast cancer progression via inducing macrophage M2 polarization. Clin Breast Cancer. 23:546–560. 2023. View Article : Google Scholar | |
He Z, Zhong Y, Regmi P, Lv T, Ma W, Wang J, Liu F, Yang S, Zhong Y, Zhou R, et al: Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway. Mol Cancer. 23:652024. View Article : Google Scholar : PubMed/NCBI | |
Tuersun H, Liu L, Zhang J, Maimaitizunong R, Tang X and Li H: m6A reading protein RBMX as a biomarker for prognosis and tumor progression in esophageal cancer. Transl Cancer Res. 12:2319–2335. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Ren S, Xue J, Dong W, He W, Luo J, Li X, Xu H, Zheng Z, Wang X, et al: DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease. J Adv Res. 74:175–189. 2024. View Article : Google Scholar : PubMed/NCBI | |
Wu Z, Zuo X, Zhang W, Li Y, Gui R, Leng J, Shen H, Pan B, Fan L, Li J and Jin H: m6A-Modified circTET2 interacting with HNRNPC regulates fatty acid oxidation to promote the proliferation of chronic lymphocytic leukemia. Adv Sci (Weinh). 10:e23048952023. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Shao Y and Li C: YTHDC1/CRM1 facilitates m6A-modified circRNA388 nuclear export to induce coelomocyte autophagy via the miR-2008/ULK axis in apostichopus japonicus. J Immunol. 212:1319–1333. 2024. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Wang H, Liu T, Zhou X, Kuai S, Ji Z and Shen H: METTL3-mediated m(6)A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis. Int Immunopharmacol. 159:1149052025. View Article : Google Scholar : PubMed/NCBI | |
Wu A, Hu Y, Xu Y, Xu J, Wang X, Cai A, Liu R, Chen L and Wang F: Methyltransferase-like 3-mediated m6A methylation of Hsa_circ_0058493 accelerates hepatocellular carcinoma progression by binding to YTH domain-containing protein 1. Front Cell Dev Biol. 9:7625882021. View Article : Google Scholar : PubMed/NCBI | |
Yang L, Chen Y, Liu N, Lu Y, Ma W, Yang Z, Gan W and Li D: CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3. Mol Cancer. 21:232022. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Jiang C, Zeng J, Guo X, Chen M and Wu B: hsa_ circ_0001599 promotes odontogenic differentiation of human dental pulp stem cells by increasing ITGA2 expression and stability. Commun Biol. 8:742025. View Article : Google Scholar | |
He T, Zhang Q, Xu P, Tao W, Lin F, Liu R, Li M, Duan X, Cai C, Gu D, et al: Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts. Mol Cancer. 22:1172023. View Article : Google Scholar : PubMed/NCBI | |
Diao X, Guo C, Zheng H, Zhao K, Luo Y, An M, Lin Y, Chen J, Li Y, Li Y, et al: SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer. Signal Transduct Target Ther. 8:4262023. View Article : Google Scholar : PubMed/NCBI | |
Yao Y, Chen C, Wang J, Xuan H, Chen X, Li Z, Yang F, Wang B, Lin S, Li S, et al: Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization. J Exp Clin Cancer Res. 42:3302023. View Article : Google Scholar : PubMed/NCBI | |
Pan Z, Zhao R, Li B, Qi Y, Qiu W, Guo Q, Zhang S, Zhao S, Xu H, Li M, et al: EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Mol Cancer. 21:162022. View Article : Google Scholar : PubMed/NCBI | |
Chen S, Wang Y, Zhang J, Liu B, Liu W, Cao G, Li R, Li H, Zhai N, Song X, et al: YTHDC1 phase separation drives the nuclear export of m(6)A-modified lncNONMMUT062668.2 through the transport complex SRSF3-ALYREF-XPO5 to aggravate pulmonary fibrosis. Cell Death Dis. 16:2792025. View Article : Google Scholar : PubMed/NCBI | |
Li T, Tian L, Cao J and Liu M: Cancer-associated fibroblasts secret extracellular vesicles to support cell proliferation and epithelial-mesenchymal transition in laryngeal squamous cell carcinoma. Mol Cell Probes. 72:1019342023. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Tian X, Wang Z, Liu D, Zhao X, Sun X, Tu Z, Li Z, Zhao Y, Zheng S and Yao J: A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD. Clin Transl Med. 14:e18012024. View Article : Google Scholar : PubMed/NCBI | |
Zeng K, Peng J, Xing Y, Zhang L, Zeng P, Li W, Zhang W, Pan Z, Zhou C and Lin J: A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis. Mol Cancer. 22:2022023. View Article : Google Scholar | |
Zheng W, Wang L, Geng S and Xu T: CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape. Cell Mol Life Sci. 81:912024. View Article : Google Scholar : PubMed/NCBI | |
Li K, Peng ZY, Wang R, Li X, Du N, Liu DP, Zhang J, Zhang YF, Ma L, Sun Y, et al: Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7. Mol Cancer. 22:1032023. View Article : Google Scholar : PubMed/NCBI | |
Zheng W, Wang L, Geng S, Yang L, Lv X, Xin S and Xu T: CircMIB2 therapy can effectively treat pathogenic infection by encoding a novel protein. Cell Death Dis. 14:5782023. View Article : Google Scholar : PubMed/NCBI | |
Tang C, Xie Y, Yu T, Liu N, Wang Z, Woolsey RJ, Tang Y, Zhang X, Qin W, Zhang Y, et al: m6A-dependent biogenesis of circular RNAs in male germ cells. Cell Res. 30:211–228. 2020. View Article : Google Scholar : PubMed/NCBI | |
Pan Z, Cai J, Lin J, Zhou H, Peng J, Liang J, Xia L, Yin Q, Zou B, Zheng J, et al: A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer. Mol Cancer. 19:712020. View Article : Google Scholar : PubMed/NCBI | |
Xiong L, Gong Y, Liu H, Huang L, Zeng Z, Zheng X, Li W, Liang Z and Kang L: circGlis3 promotes β-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein. iScience. 27:1086802024. View Article : Google Scholar | |
Sun W, Zhou S, Peng L, Liu Y, Cheng D, Wang Y and Ni C: CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function. Cell Mol Biol Lett. 28:1052023. View Article : Google Scholar : | |
Wu S, Zhang L, Deng J, Guo B, Li F, Wang Y, Wu R, Zhang S, Lu J and Zhou Y: A novel micropeptide encoded by Y-linked LINC00278 links cigarette smoking and AR signaling in male esophageal squamous cell carcinoma. Cancer Res. 80:2790–2803. 2020. View Article : Google Scholar : PubMed/NCBI | |
Pei H, Dai Y, Yu Y, Tang J, Cao Z, Zhang Y, Li B, Nie J, Hei TK and Zhou G: The tumorigenic effect of lncRNA AFAP1-AS1 is mediated by translated peptide ATMLP under the control of m6A methylation. Adv Sci (Weinh). 10:e23003142023. View Article : Google Scholar | |
Shen G, Li F, Wang Y, Huang Y, Aizezi G, Yuan J, Ma C and Lin C: New insights on the interaction between m6A modification and non-coding RNA in cervical squamous cell carcinoma. World J Surg Oncol. 21:252023. View Article : Google Scholar | |
Wu C, Cui J, Huo Y, Shi L and Wang C: Alternative splicing of HOXB-AS3 underlie the promoting effect of nuclear m6A reader YTHDC1 on the self-renewal of leukemic stem cells in acute myeloid leukemia. Int J Biol Macromol. 237:1239902023. View Article : Google Scholar | |
Leng F, Miu YY, Zhang Y, Luo H, Lu XL, Cheng H and Zheng ZG: A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc. Oncol Lett. 22:6972021. View Article : Google Scholar : PubMed/NCBI | |
Lin M, Zhou X, Yang Y, Xie P, Li Q, He C, Lin Q, Wei X and Ding Y: A peptide encoded by lncRNA HOXB-AS3 promotes cigarette smoke-induced inflammation in bronchial epithelial cells via EZH2-Mediated H3K27me3 modification. Int J Chron Obstruct Pulmon Dis. 20:1543–1553. 2025. View Article : Google Scholar : PubMed/NCBI | |
Ge Q, Jia D, Cen D, Qi Y, Shi C, Li J, Sang L, Yang LJ, He J, Lin A, et al: Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. J Clin Invest. 131:e1529112021. View Article : Google Scholar : PubMed/NCBI | |
Zhang M, Cai R, Liu J, Wang Y, He S, Wang Q, Song X, Wu J and Zhao J: Multi-omics integration analysis reveals the role of N6-methyladenosine in lncRNA translation during glioma stem cell differentiation. Brief Funct Genomics. 23:806–815. 2024. View Article : Google Scholar : PubMed/NCBI | |
Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, et al: Circular RNA encoded MET variant promotes glioblastoma tumorigenesis. Nat Commun. 14:44672023. View Article : Google Scholar : PubMed/NCBI | |
Wang T, Liu Z, She Y, Deng J, Zhong Y, Zhao M, Li S, Xie D, Sun X, Hu X and Chen C: A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. Cancer Lett. 520:321–331. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lu J, Ru J, Chen Y, Ling Z, Liu H, Ding B, Jiang Y, Ma J, Zhang D, Ge J, et al: N6 -methyladenosine-modified circSTX6 promotes hepatocellular carcinoma progression by regulating the HNRNPD/ATF3 axis and encoding a 144 amino acid polypeptide. Clin Transl Med. 13:e14512023. View Article : Google Scholar | |
Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, et al: HNRNPL circularizes ARHGAP35 to produce an oncogenic protein. Adv Sci (Weinh). 8:20017012021. View Article : Google Scholar : PubMed/NCBI | |
Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, et al: The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment. Nat Commun. 16:3332025. View Article : Google Scholar : PubMed/NCBI | |
Zhong S, Xu H, Wang D, Yang S, Li H, Zhang H, Feng J and Zhou S: circNFIB decreases synthesis of arachidonic acid and inhibits breast tumor growth and metastasis. Eur J Pharmacol. 963:1762212024. View Article : Google Scholar | |
Wei C, Peng D, Jing B, Wang B, Li Z, Yu R, Zhang S, Cai J, Zhang Z, Zhang J and Han L: A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ. Cell Mol Biol Lett. 29:1272024. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Liu Z, Zhong Z, Ji Y, Guo H, Wang W and Chen C: A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity. J Exp Clin Cancer Res. 43:522024. View Article : Google Scholar : PubMed/NCBI | |
Li M, Ding W, Fang X, Wang Y, Wang P, Ye L, Miao S, Song L, Ao X, Li Q and Wang J: Novel truncated peptide derived from circCDYL exacerbates cardiac hypertrophy. Circ Res. 136:e94–e112. 2025. View Article : Google Scholar : PubMed/NCBI | |
Zhou B, Yu G, Zhao M, Li Y, Li J, Xiang Y, Tong L, Chu X, Wang C and Song Y: The lncRNA LINC00339-encoded peptide promotes trophoblast adhesion to endometrial cells via MAPK and PI3K-Akt signaling pathways. J Assist Reprod Genet. 41:493–504. 2024. View Article : Google Scholar : | |
Zhu HX, Lu WJ, Zhu WP and Yu S: Comprehensive analysis of N6 -methyladenosine-related long non-coding RNAs for prognosis prediction in liver hepatocellular carcinoma. J Clin Lab Anal. 35:e240712021. View Article : Google Scholar | |
Xiao W, Halabi R, Lin CH, Nazim M, Yeom KH and Black DL: The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons. Genes Dev. 38:294–307. 2024. View Article : Google Scholar : | |
Ming Y, Deng Z, Tian X, Jia Y, Ning M and Cheng S: m6A methyltransferase METTL3 reduces hippocampal neuron apoptosis in a mouse model of autism through the MALAT1/SFRP2/Wnt/β-catenin axis. Psychiatry Investig. 19:771–787. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zheng W, Guo Y, Zhang G, Bai J, Song Y, Song X, Zhu Q, Bao X, Wu G and Zhang C: Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway. PLoS One. 18:e02871332023. View Article : Google Scholar : PubMed/NCBI | |
Wu J, Cai Y, Zhao G and Li M: A ten N6-methyladenosine-related long non-coding RNAs signature predicts prognosis of triple-negative breast cancer. J Clin Lab Anal. 35:e237792021. View Article : Google Scholar : PubMed/NCBI | |
Min XL, Lin SX, Zhao XH, Zhao Q, Li YF, Li XH, Liu XY, Cao Y, Sun YL and Zeng Y: Mechanisms of METTL14-mediated m6A modification in promoting iron overload-induced lipid peroxidative damage in vascular endothelial cells to aggravate atherosclerosis. J Biochem Mol Toxicol. 38:e700662024. View Article : Google Scholar : PubMed/NCBI | |
Shen C, Chen X, Lin Y and Yang Y: Hypoxia triggers cardiomyocyte apoptosis via regulating the m6A methylation-mediated LncMIAT/miR-708-5p/p53 axis. Heliyon. 10:e324552024. View Article : Google Scholar | |
Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M and Wang J: Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis. Cell Mol Biol Lett. 29:32024. View Article : Google Scholar : PubMed/NCBI | |
Zhang HR, Ma GQ, Lv HQ, Feng YT and Peng YJ: Electroacupuncture alleviates cerebral ischemia-reperfusion injury by regulating the S1PR2/TLR4/NLRP3 signaling pathway via m6A methylation of lncRNA H19. Curr Neurovasc Res. 21:64–73. 2024. View Article : Google Scholar : PubMed/NCBI | |
Yu P, Wang J, Xu GE, Zhao X, Cui X, Feng J, Sun J, Wang T, Spanos M, Lehmann HI, et al: RNA m(6)A-Regulated circ-ZNF609 suppression ameliorates doxorubicin-induced cardiotoxicity by upregulating FTO. JACC Basic Transl Sci. 8:677–698. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yuan J, Liu Y, Zhou L, Xue Y, Lu Z and Gan J: YTHDC2-mediated circYTHDC2 N6-methyladenosine modification promotes vascular smooth muscle Cells dysfunction through inhibiting ten-eleven translocation 2. Front Cardiovasc Med. 8:6862932021. View Article : Google Scholar : PubMed/NCBI | |
Tian Y, Xiao YH, Sun C, Liu B and Sun F: N6-Methyladenosine methyltransferase METTL3 alleviates diabetes-induced testicular damage through modulating TUG1/Clusterin axis. Diabetes Metab J. 47:287–300. 2023. View Article : Google Scholar : PubMed/NCBI | |
Fu S, Zhou Q, Peng X, Hu Y, Xiong J and Liu F: METTL3/YTHDC1 mediates up-regulation of lncRNA OGRU in an m6A-dependent manner involving in oxidative stress and inflammation of HG-induced Müller cells. Immunol Lett. 272:1069722025. View Article : Google Scholar | |
Li C, Su F, Liang Z, Zhang L, Liu F, Fan W and Li Z: Macrophage M1 regulatory diabetic nephropathy is mediated by m6A methylation modification of lncRNA expression. Mol Immunol. 144:16–25. 2022. View Article : Google Scholar : PubMed/NCBI | |
Guo C, Yu M, Liu J, Jia Z, Liu H and Zhao S: Molecular mechanism of Wilms tumour 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1. J Drug Target. 32:200–212. 2024. View Article : Google Scholar | |
Zheng M, Cun D, He H, Xie X, Lei H, Fu W, Tai W and Yang J: Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD. BMC Gastroenterol. 25:1622025. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Jian H, Shang S, Lu L, Lou Y, Kang Y, Bai H, Fu Z, Lv Y, Kong X, et al: Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons. Epigenetics. 18:21815752023. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Yang S, Han S, Sun Y, Han M, Zheng X, Li F, Wei Y, Wang Y and Bi J: Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model. Mol Med Rep. 27:552023. View Article : Google Scholar : PubMed/NCBI | |
Liu X, Li Z, Tong J, Wu F, Jin H and Liu K: Characterization of the expressions and m6A methylation modification patterns of mRNAs and lncRNAs in a spinal cord injury rat model. Mol Neurobiol. 62:806–818. 2025. View Article : Google Scholar : | |
Atrian F, Ramirez P, De Mange J, Ramirez P, Atrian F, Morita M and Frost B: m6A-dependent circular RNA formation mediates tau-induced neurotoxicity. bioRxiv. 23:e142452024. | |
Zhang H, Xu X, Li X, Zeng C and Peng Y: Electroacupuncture serum alleviates Ogd/R-induced astrocyte damage by regulating the AQP4 Via m6A methylation of lncRNA MALAT1. Neurochem Res. 50:1392025. View Article : Google Scholar : PubMed/NCBI | |
Sun H, Liu F, Song X, Sun R, Zhang M, Huang J, Gu W and Shao Y: m6A-modified circCREBBP enhances radiosensitivity of esophageal squamous cell carcinoma by reducing the stability of MYC through interaction with IGF2BP3. Int J Biol Macromol. 286:1385342025. View Article : Google Scholar | |
Wang F, Wen J, Liu J, Xin L, Fang Y, Sun Y and He M: Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule. Front Immunol. 16:15567642025. View Article : Google Scholar : PubMed/NCBI | |
Canaani J, Danylesko I, Shemtov N, Zlotnick M, Lozinsky K, Benjamini O, Yerushalmi R, Nagar M, Dor C, Shimoni A, et al: A phase II study of bisantrene in patients with relapsed/refractory acute myeloid leukemia. Eur J Haematol. 106:260–266. 2021. View Article : Google Scholar | |
Pomaville M, Chennakesavalu M, Wang P, Jiang Z, Sun HL, Ren P, Borchert R, Gupta V, Ye C, Ge R, et al: Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation. Cell Rep. 43:1141652024. View Article : Google Scholar : PubMed/NCBI | |
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, et al: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 593:597–601. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lee JH, Choi N, Kim S, Jin MS, Shen H and Kim YC: Eltrombopag as an allosteric inhibitor of the METTL3-14 complex affecting the m6A methylation of RNA in acute myeloid leukemia cells. Pharmaceuticals (Basel). 15:4402022. View Article : Google Scholar | |
Wu Z, Smith AR, Qian Z and Zheng G: Patent landscape of small molecule inhibitors of METTL3 (2020-present). Expert Opin Ther Pat. 26:1–16. 2024. | |
Wu J, Pang R, Li M, Chen B, Huang J and Zhu Y: m6A-Induced LncRNA MEG3 suppresses the proliferation, migration and invasion of hepatocellular carcinoma cell through miR-544b/BTG2 signaling. Onco Targets Ther. 14:3745–3755. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li P, Mi Q, Yan S, Xie Y, Cui Z, Zhang S, Wang Y, Gao H, Wang Y, Li J, et al: Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-β2 signaling axis. Cell Death Dis. 14:592023. View Article : Google Scholar | |
Liu Q, Zhou BM, Wang LJ and Zhang CY: Construction of a hierarchical DNA circuit for single-molecule profiling of locus-specific N6-methyladenosine-MALAT1 in clinical tissues. Biosens Bioelectron. 274:1171982025. View Article : Google Scholar | |
Zhang J, Liu T, Wang Y, Yan X, Li Y, Xu F and Zhang R: Dynamic alterations of the transcriptome-wide m6A methylome in cytogenetically normal acute myeloid leukaemia during initial diagnosis and relapse. Genomics. 115:1107252023. View Article : Google Scholar |