Open Access

Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review)

  • Authors:
    • Junxin Li
    • Yu Huang
    • Lin Fu
    • Ming Shi
    • Gongli Hu
    • Fei Du
    • Zhongshu Wang
    • Yi Xiao
    • Yan Zhang
    • Yanyu Li
  • View Affiliations

  • Published online on: July 11, 2025     https://doi.org/10.3892/ijo.2025.5774
  • Article Number: 68
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer‑associated fibroblasts (CAFs) represent an important component of the stromal cell population within the tumor microenvironment (TME) and are intricately linked to tumor growth, metastasis and drug resistance. In the TME, non‑coding RNAs present in exosomes act as essential mediators of intercellular communication. Exosomal RNAs derived from cancer cells activate CAFs, which in turn regulate cancer cell proliferation, invasion and drug resistance. Conversely, exosomal RNAs derived from CAFs contribute to therapeutic resistance in cancer by modulating survival signaling pathways, epithelial‑mesenchymal transition, programmed cell death, drug transporter expression levels and immune evasion. The present review examines the role and mechanisms of exosomal RNAs in CAF‑mediated cancer therapeutic resistance and offers recommendations for future research based on the underlying mechanisms of CAF‑induced drug resistance.
View Figures
View References

Related Articles

Journal Cover

August-2025
Volume 67 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Huang Y, Fu L, Shi M, Hu G, Du F, Wang Z, Xiao Y, Zhang Y, Li Y, Li Y, et al: Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review). Int J Oncol 67: 68, 2025.
APA
Li, J., Huang, Y., Fu, L., Shi, M., Hu, G., Du, F. ... Li, Y. (2025). Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review). International Journal of Oncology, 67, 68. https://doi.org/10.3892/ijo.2025.5774
MLA
Li, J., Huang, Y., Fu, L., Shi, M., Hu, G., Du, F., Wang, Z., Xiao, Y., Zhang, Y., Li, Y."Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review)". International Journal of Oncology 67.2 (2025): 68.
Chicago
Li, J., Huang, Y., Fu, L., Shi, M., Hu, G., Du, F., Wang, Z., Xiao, Y., Zhang, Y., Li, Y."Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review)". International Journal of Oncology 67, no. 2 (2025): 68. https://doi.org/10.3892/ijo.2025.5774