Open Access

Inextricable association of connective tissue disease with B‑cell lymphoma (Review)

  • Authors:
    • Jing-Shu Ruan
    • Shan Xu
    • Ning-Ning Shan
  • View Affiliations

  • Published online on: April 1, 2025     https://doi.org/10.3892/mco.2025.2843
  • Article Number: 48
  • Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Connective tissue disease (CTD) is a kind of autoimmune disease with multisystem damage that mainly involves the bone, muscle and the vascular system. Patients with CTD have an increased incidence of malignant tumors, particularly hematological malignancies, compared to the general population. This association of autoimmune diseases with lymphoproliferative diseases is bidirectional. There is a heightened risk of B‑cell lymphoma development among patients with CTD, and patients with autoimmune disease display a higher prevalence of non‑Hodgkin lymphoma compared to the general population. More than 80% of malignant tumours occur after or at the same time as CTD develops. Among secondary lymphomas, the most common aggressive type of lymphoma is diffuse large B‑cell lymphoma, while the most common indolent type is marginal zone lymphoma. Novel targets in patients with B‑cell lymphoma are BCL2, the NF‑κB pathway, components of the BCR activator of RhoGEF and GTPase signalling pathway and the PI3K‑mTOR pathway. In this review, information is provided on the common types of B‑cell lymphoma in CTD, the pathogenic factors implicated in lymphoma development and recent advancements in therapies effective for both autoimmune conditions and malignant lymphoproliferative diseases.
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June-2025
Volume 22 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Ruan J, Xu S and Shan N: Inextricable association of connective tissue disease with B‑cell lymphoma (Review). Mol Clin Oncol 22: 48, 2025.
APA
Ruan, J., Xu, S., & Shan, N. (2025). Inextricable association of connective tissue disease with B‑cell lymphoma (Review). Molecular and Clinical Oncology, 22, 48. https://doi.org/10.3892/mco.2025.2843
MLA
Ruan, J., Xu, S., Shan, N."Inextricable association of connective tissue disease with B‑cell lymphoma (Review)". Molecular and Clinical Oncology 22.6 (2025): 48.
Chicago
Ruan, J., Xu, S., Shan, N."Inextricable association of connective tissue disease with B‑cell lymphoma (Review)". Molecular and Clinical Oncology 22, no. 6 (2025): 48. https://doi.org/10.3892/mco.2025.2843