Open Access

Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non‑small cell lung cancer

  • Authors:
    • Keiichiro Suminaga
    • Hironori Yoshida
    • Yusuke Shima
    • Hiroshi Yoshida
    • Kentaro Hashimoto
    • Tatsuya Ogimoto
    • Kazutaka Hosoya
    • Tomoko Funazo
    • Hitomi Ajimizu
    • Takashi Nomizo
    • Masahiro Yoneyama
    • Noriko Kishi
    • Hiroaki Ozasa
    • Toyohiro Hirai
  • View Affiliations

  • Published online on: July 10, 2025     https://doi.org/10.3892/mco.2025.2879
  • Article Number: 84
  • Copyright: © Suminaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Locoregional recurrence is one of the main failure patterns following curative treatment for non‑small cell lung cancer (NSCLC). Although an optimal treatment strategy for patients with locoregional recurrence has not yet been established, chemoradiotherapy (CRT) is widely used in clinical practice. Treatment with CRT followed by durvalumab, a programmed death ligand 1 inhibitor, has become the standard treatment for unresectable locally advanced NSCLC. However, the efficacy of durvalumab consolidation therapy for locoregional recurrent NSCLC remains unclear. Therefore, patients with NSCLC treated with CRT at the Kyoto University Hospital (Kyoto, Japan) between January 2010 and December 2022, were retrospectively analyzed. The efficacy and safety of durvalumab consolidation between patients with locoregionally recurrent and locally advanced NSCLC who received treatment and those who did not were compared. Among 198 patients with NSCLC treated with CRT, 43 had a locoregional recurrence and 12 received durvalumab consolidation. The median progression‑free survival (PFS) was not reached in the durvalumab group and was 13.6 months in the non‑durvalumab group [hazard ratio (HR), 0.69; 95% confidence interval, 0.28‑1.71; P=0.42). The 12‑, 18‑, and 24‑month PFS rates in the durvalumab group were 58.3, 58.3, and 50.0%, respectively. Pneumonitis was more frequent in the durvalumab group; however, no grade 3 or higher cases were observed. In conclusion, durvalumab consolidation after CRT for locoregional recurrent NSCLC demonstrated favorable efficacy and acceptable toxicity compared with treatment without durvalumab. Similar to patients with locally advanced NSCLC, those with locoregionally recurrent NSCLC may benefit from durvalumab consolidation therapy after CRT.
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September-2025
Volume 23 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Suminaga K, Yoshida H, Shima Y, Yoshida H, Hashimoto K, Ogimoto T, Hosoya K, Funazo T, Ajimizu H, Nomizo T, Nomizo T, et al: Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non‑small cell lung cancer. Mol Clin Oncol 23: 84, 2025.
APA
Suminaga, K., Yoshida, H., Shima, Y., Yoshida, H., Hashimoto, K., Ogimoto, T. ... Hirai, T. (2025). Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non‑small cell lung cancer. Molecular and Clinical Oncology, 23, 84. https://doi.org/10.3892/mco.2025.2879
MLA
Suminaga, K., Yoshida, H., Shima, Y., Yoshida, H., Hashimoto, K., Ogimoto, T., Hosoya, K., Funazo, T., Ajimizu, H., Nomizo, T., Yoneyama, M., Kishi, N., Ozasa, H., Hirai, T."Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non‑small cell lung cancer". Molecular and Clinical Oncology 23.3 (2025): 84.
Chicago
Suminaga, K., Yoshida, H., Shima, Y., Yoshida, H., Hashimoto, K., Ogimoto, T., Hosoya, K., Funazo, T., Ajimizu, H., Nomizo, T., Yoneyama, M., Kishi, N., Ozasa, H., Hirai, T."Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non‑small cell lung cancer". Molecular and Clinical Oncology 23, no. 3 (2025): 84. https://doi.org/10.3892/mco.2025.2879