Open Access

Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review)

  • Authors:
    • Qilong Zhou
    • Weijie Gao
    • Weijin Zhang
    • Shu Tang
    • Hongxue Fu
    • Pengfei Pan
  • View Affiliations

  • Published online on: May 21, 2025     https://doi.org/10.3892/mmr.2025.13573
  • Article Number: 208
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sepsis is characterized by a dysregulated systemic inflammatory response to infection. Despite substantial advances in its treatment, sepsis remains a significant global health burden. An understanding of the underlying mechanisms driving sepsis is crucial for the development of targeted therapeutic strategies. Silent information regulator 1 (SIRT1), a member of the class III histone deacetylases, plays a pivotal role in regulating gene expression by catalyzing the deacetylation of lysine residues on non‑histone and histone proteins. SIRT1 has been shown to exert significant anti‑inflammatory, anti‑oxidative, anti‑apoptotic and metabolic regulatory effects, making it a potential therapeutic target for sepsis. The present study reviewed the latest research progress on the signaling pathways modulated by SIRT1 in sepsis and its associated regulatory mechanisms to further elucidate the pathogenesis of sepsis and guide its clinical treatment.
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August-2025
Volume 32 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Q, Gao W, Zhang W, Tang S, Fu H and Pan P: Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review). Mol Med Rep 32: 208, 2025.
APA
Zhou, Q., Gao, W., Zhang, W., Tang, S., Fu, H., & Pan, P. (2025). Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review). Molecular Medicine Reports, 32, 208. https://doi.org/10.3892/mmr.2025.13573
MLA
Zhou, Q., Gao, W., Zhang, W., Tang, S., Fu, H., Pan, P."Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review)". Molecular Medicine Reports 32.2 (2025): 208.
Chicago
Zhou, Q., Gao, W., Zhang, W., Tang, S., Fu, H., Pan, P."Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review)". Molecular Medicine Reports 32, no. 2 (2025): 208. https://doi.org/10.3892/mmr.2025.13573