Open Access

Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review)

  • Authors:
    • Liwen Zhao
    • Chuting Feng
    • Yong-Jing Gao
    • Tianzhen He
  • View Affiliations

  • Published online on: July 8, 2025     https://doi.org/10.3892/mmr.2025.13615
  • Article Number: 250
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incorporation of immune checkpoint inhibitors (ICIs) into cancer treatment has revolutionized oncology, providing marked advantages in managing various types of cancer. Nevertheless, the increasing use of ICIs has led to the emergence of immune‑related side effects, including autoimmune diseases such as inflammatory arthritis. IL‑6 signaling is crucial in the development of inflammatory arthritis and is linked to both the benefits and adverse effects of ICIs. The present review summarizes the latest progress in the IL‑6 pathway in inflammatory arthritis and discusses the therapeutic potential of IL‑6 pathway inhibitors for ICI‑induced inflammatory arthritis.
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September-2025
Volume 32 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao L, Feng C, Gao Y and He T: Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review). Mol Med Rep 32: 250, 2025.
APA
Zhao, L., Feng, C., Gao, Y., & He, T. (2025). Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review). Molecular Medicine Reports, 32, 250. https://doi.org/10.3892/mmr.2025.13615
MLA
Zhao, L., Feng, C., Gao, Y., He, T."Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review)". Molecular Medicine Reports 32.3 (2025): 250.
Chicago
Zhao, L., Feng, C., Gao, Y., He, T."Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review)". Molecular Medicine Reports 32, no. 3 (2025): 250. https://doi.org/10.3892/mmr.2025.13615