How transcription factors regulate apoptosis in endometriosis (Review)
- Authors:
- Zhuqing Ouyang
- Juexiao Deng
- Lanyue Zhang
- Fujin Shen
-
Affiliations: Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China - Published online on: August 18, 2025 https://doi.org/10.3892/mmr.2025.13654
- Article Number: 289
-
Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Giudice LC: Clinical practice. Endometriosis. N Engl J Med. 362:2389–2398. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ochoa Bernal MA and Fazleabas AT: The Known, the unknown and the future of the pathophysiology of endometriosis. Int J Mol Sci. 25:58152024. View Article : Google Scholar : PubMed/NCBI | |
|
Chen F, Zhu M and Li W: Advances in research on malignant transformation of endometriosis-associated ovarian cancer. Front Oncol. 14:14752312024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Nicholes K and Shih IM: The origin and pathogenesis of endometriosis. Annu Rev Pathol. 15:71–95. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Muraoka A, Suzuki M, Hamaguchi T, Watanabe S, Iijima K, Murofushi Y, Shinjo K, Osuka S, Hariyama Y, Ito M, et al: Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Sci Transl Med. 15:eadd153120223 View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Fu F, Li Y, Li S, Yuan M, Wang T, Ren W, Wei J, Chen D, Wang S, et al: MEIS1-mediated apoptosis via TNFR1 in endometriosis. Reprod Sci. 32:716–727. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Guo SW, Habiba M and Benagiano G: From retrograde menstruation to endometrial determinism and a brave new World of ‘Root Treatment’ of endometriosis: Destiny or a Fanciful Utopia? Biomolecules. 13:3362023. View Article : Google Scholar : PubMed/NCBI | |
|
Harada T, Kaponis A, Iwabe T, Taniguchi F, Makrydimas G, Sofikitis N, Paschopoulos M, Paraskevaidis E and Terakawa N: Apoptosis in human endometrium and endometriosis. Hum Reprod Update. 10:29–38. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Björk E, Israelsson P, Nagaev I, Nagaeva O, Lundin E, Ottander U and Mincheva-Nilsson L: Endometriotic Tissue-derived exosomes downregulate NKG2D-mediated cytotoxicity and promote apoptosis: Mechanisms for survival of ectopic endometrial tissue in endometriosis. J Immunol. 213:567–576. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Reis FM, Petraglia F and Taylor RN: Endometriosis: Hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update. 19:406–418. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Béliard A, Noël A and Foidart JM: Reduction of apoptosis and proliferation in endometriosis. Fertil Steril. 82:80–85. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hengartner MO: The biochemistry of apoptosis. Nature. 407:770–776. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan J and Ofengeim D: A guide to cell death pathways. Nat Rev Mol Cell Biol. 25:379–95. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Glover HL, Schreiner A, Dewson G and Tait SWG: Mitochondria and cell death. Nat Cell Biol. 26:1434–1436. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Moyer A, Tanaka K and Cheng EH: Apoptosis in cancer biology and therapy. Annu Rev Pathol. 20:303–328. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang B, Li SJ, Yuan H, Cong SS, Zhao SJ and Yang XJ: FOXL2 knockdown inhibits the progression of endometriosis. Am J Reprod Immunol. 93:e700432025. View Article : Google Scholar : PubMed/NCBI | |
|
Tan A, Prasad R, Lee C and Jho EH: Past, present, and future perspectives of transcription factor EB (TFEB): Mechanisms of regulation and association with disease. Cell Death Differ. 29:1433–1449. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng G, Pan Z, Zhan Y, Tang Q, Zheng F, Zhou Y, Wu Y, Zhou Y, Chen D, Chen J, et al: TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux. Osteoarthritis Cartilage. 27:347–357. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Q, Zhou Y, Yu M, Zhu S, Sun J, Du W, Chen Z, Tao J, Feng X, Zhang Q and Zhao Y: Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis. Apoptosis. 29:757–767. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Bata N and Cosford NDP: Cell survival and cell death at the intersection of autophagy and apoptosis: Implications for current and future cancer therapeutics. ACS Pharmacol Transl Sci. 4:1728–1746. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Maiuri MC, Zalckvar E, Kimchi A and Kroemer G: Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 8:741–752. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Mariño G, Niso-Santano M, Baehrecke EH and Kroemer G: Self-consumption: The interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 15:81–94. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
He R, Shi X, Zhou M, Zhao Y, Pan S, Zhao C, Guo X, Wang M, Li X and Qin R: Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of Autophagy-lysosome pathway via targeting TFEB. Toxicol Appl Pharmacol. 356:159–171. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng B, Wang Y, Zhou B, Qian F, Liu D, Ye D, Zhou X and Fang L: Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages. J Adv Res. 69:125–138. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Lu H, Sun J, Hamblin MH, Chen YE and Fan Y: Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 63:10320720210 View Article : Google Scholar : PubMed/NCBI | |
|
Lu H, Sun J, Liang W, Chang Z, Rom O, Zhao Y, Zhao G, Xiong W, Wang H, Zhu T, et al: Cyclodextrin prevents abdominal aortic aneurysm via activation of vascular smooth muscle cell transcription Factor EB. Circulation. 142:483–498. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu L, Yuan Y, Yuan L, Li L, Liu F, Liu J, Chen Y, Lu Y and Cheng J: Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Theranostics. 10:5829–5844. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N and Zhang Z: CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis. Stem Cell Res Ther. 13:2942022. View Article : Google Scholar : PubMed/NCBI | |
|
Choi J, Jo M, Lee E, Lee DY and Choi D: Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT, ERK1/2, and mTOR. Fertil Steril. 104:655–664.e1. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kobayashi H, Imanaka S, Yoshimoto C, Matsubara S and Shigetomi H: Molecular mechanism of autophagy and apoptosis in endometriosis: Current understanding and future research directions. Reprod Med Biol. 23:e125772024. View Article : Google Scholar : PubMed/NCBI | |
|
D'Amico R, Impellizzeri D, Cordaro M, Siracusa R, Interdonato L, Marino Y, Crupi R, Gugliandolo E, Macrì F, Di Paola D, et al: Complex interplay between autophagy and oxidative stress in the development of endometriosis. Antioxidants (Basel). 11:24842022. View Article : Google Scholar : PubMed/NCBI | |
|
Driva TS, Schatz C, Sobočan M and Haybaeck J: The role of mTOR and eIF Signaling in benign endometrial diseases. Int J Mol Sci. 23:34162022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, et al: MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 7:121092016. View Article : Google Scholar : PubMed/NCBI | |
|
Pan B, Li J, Parajuli N, Tian Z, Wu P, Lewno MT, Zou J, Wang W, Bedford L, Mayer RJ, et al: The calcineurin-TFEB-p62 pathway mediates the activation of cardiac macroautophagy by proteasomal malfunction. Circ Res. 127:502–518. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen C, Zhou Y, Hu C, Wang Y, Yan Z, Li Z and Wu R: Mitochondria and oxidative stress in ovarian endometriosis. Free Radic Biol Med. 136:22–34. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H, Wang B, Wu M, Lu J and Duan P: Targeting osteopontin alleviates endometriosis and inflammation by inhibiting the RhoA/ROS axis and achieves non-invasive in vitro detection via menstrual blood. Hum Reprod. 39:1057–1071. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Bisicchia E, Mastrantonio R, Nobili A, Palazzo C, La Barbera L, Latini L, Millozzi F, Sasso V, Palacios D, D'Amelio M and Viscomi MT: Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload. Cell Death Dis. 13:3812022. View Article : Google Scholar : PubMed/NCBI | |
|
Sun X, Chang R, Tang Y, Luo S, Jiang C, Jia H, Xu Q, Dong Z, Liang Y, Loor JJ and Xu C: Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H2O2-induced oxidative damage in vitro. J Anim Sci Biotechnol. 12:352021. View Article : Google Scholar : PubMed/NCBI | |
|
Huang J, Chen X and Lv Y: HMGB1 mediated inflammation and autophagy contribute to endometriosis. Front Endocrinol (Lausanne). 12:6166962021. View Article : Google Scholar : PubMed/NCBI | |
|
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J and Jiang H: Realgar-induced neurotoxicity: Crosstalk between the Autophagic Flux and the p62-NRF2 feedback loop mediates p62 accumulation to promote apoptosis. Mol Neurobiol. 60:6001–6017. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Feng X, Chen L, Guo W, Zhang Y, Lai X, Shao L and Li Y: Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. Acta Biomater. 81:278–292. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu S, Yao S, Yang H, Liu S and Wang Y: Autophagy: Regulator of cell death. Cell Death Dis. 14:6482023. View Article : Google Scholar : PubMed/NCBI | |
|
Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mukhopadhyay S, Panda PK, Sinha N, Das DN and Bhutia SK: Autophagy and apoptosis: Where do they meet? Apoptosis. 19:555–566. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan HQ, Qin R, Li YL, Liu MM and Gan L: TFEB promotes BCL-2 expression by upregulating its promoter activity in the t(6;11) translocation renal cell carcinomas. Am J Transl Res. 13:8804–8818. 2021.PubMed/NCBI | |
|
Alabiad MA, Elhasadi I, Aljafil R, Shalaby AM, Alshaikh ABA, Edris FE, Heraiz AI, Alorini M, Aboregela AM and Mohamed AH: A novel triad for the diagnosis of endometriosis, the short anogenital distance combines with high endometrial BCL2 and low endometrial FASL. Int J Gynaecol Obstet. 166:297–304. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Florio TJ, Lokareddy RK, Yeggoni DP, Sankhala RS, Ott CA, Gillilan RE and Cingolani G: Differential recognition of canonical NF-κB dimers by Importin α3. Nat Commun. 13:12072022. View Article : Google Scholar : PubMed/NCBI | |
|
Pavitra E, Kancharla J, Gupta VK, Prasad K, Sung JY, Kim J, Tej MB, Choi R, Lee JH, Han YK, et al: The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy. Biomed Pharmacother. 163:1148222023. View Article : Google Scholar : PubMed/NCBI | |
|
Minocha T, Das M, Rai V, Verma SS, Awasthee N, Gupta SC, Haldar C and Yadav SK: Melatonin induces apoptosis and cell cycle arrest in cervical cancer cells via inhibition of NF-κB pathway. Inflammopharmacology. 30:1411–1429. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Yang W, Liu L, Li C, Luo N, Chen R, Li L, Yu F and Cheng Z: TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway. Cell Death Dis. 9:9082018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Wang J and Zhang X: An update on the multifaceted role of NF-kappaB in endometriosis. Int J Biol Sci. 18:4400–4413. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T and Zhang J: NF-κB in biology and targeted therapy: New insights and translational implications. Signal Transduct Target Ther. 9:532024. View Article : Google Scholar : PubMed/NCBI | |
|
Zdrojkowski Ł, Jasiński T, Ferreira-Dias G, Pawliński B and Domino M: The role of NF-κB in endometrial diseases in humans and animals: A review. Int J Mol Sci. 24:29012023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M, Xu T, Tong D, Li S, Yu X, Liu B, Jiang L and Liu K: Research advances in endometriosis-related signaling pathways: A review. Biomed Pharmacother. 64:1149092023. View Article : Google Scholar : PubMed/NCBI | |
|
Karin M and Ben-Neriah Y: Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol. 18:621–663. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
González-Ramos R, Defrère S and Devoto L: Nuclear factor-kappaB: A main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertil Steril. 98:520–528. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Aggarwal BB, Vijayalekshmi RV and Sung B: Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe. Clin Cancer Res. 15:425–430. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cherry EM, Lee DW, Jung JU and Sitcheran R: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling. Mol Cancer. 14:92015. View Article : Google Scholar : PubMed/NCBI | |
|
McKinnon BD, Kocbek V, Nirgianakis K, Bersinger NA and Mueller MD: Kinase signalling pathways in endometriosis: Potential targets for Non-hormonal therapeutics. Hum Reprod Update. 22:382–403. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Castro I, Wright JA, Damdinsuren B, Hoek KL, Carlesso G, Shinners NP, Gerstein RM, Woodland RT, Sen R and Khan WN: B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J Immunol. 182:7729–7737. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Haselager M, Thijssen R, West C, Young L, Van Kampen R, Willmore E, Mackay S, Kater A and Eldering E: Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL. Cell Death Differ. 28:1658–1668. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang D, Zhang Y, Cui L, Yang Q and Wang J: Elevated latent transforming growth factor beta binding protein 2 in endometriosis promotes endometrial stromal cell invasion and proliferation via the NF-kB signaling pathway. Mol Cell Endocrinol. 550:1116472022. View Article : Google Scholar : PubMed/NCBI | |
|
Pang XF, Lin X, Du JJ and Zeng DY: LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Acta Physiol (Oxf). 228:e133772020. View Article : Google Scholar : PubMed/NCBI | |
|
Cao WG, Morin M, Sengers V, Metz C, Roger T, Maheux R and Akoum A: Tumour necrosis factor-alpha up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-kappaB. Hum Reprod. 21:421–428. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Delaney AA, Khan Z, Zheng Y, Correa LF, Zanfagnin V, Shenoy CC, Schoolmeester JK, Saadalla AM, El-Nashar S, Famuyide AO, et al: KLF10 mediated epigenetic dysregulation of epithelial CD40/CD154 promotes endometriosis. Biol Reprod. 95:622016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Zha X, Ruan S, Yao S and Zhang X: Kruppel like factor 10 up-regulates PDZ and LIM domain containing protein 2 via nuclear factor kappa-B pathway to inhibit proliferation and inflammatory of fibroblastoid synovial cell in rheumatoid arthritis. Bioengineered. 13:1779–1790. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Gasparini C, Celeghini C, Monasta L and Zauli G: NF-κB pathways in hematological malignancies. Cell Mol Life Sci. 71:2083–2102. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu F, Wang Z, Wei Y, Liu R, Jiang C, Gong C, Liu Y and Yan B: The leading role of adsorbed lead in PM2.5-induced hippocampal neuronal apoptosis and synaptic damage. J Hazard Mater. 416:1258672021. View Article : Google Scholar : PubMed/NCBI | |
|
Takimoto R and El-Deiry WS: Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene. 19:1735–1743. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Xia Z, Li M, Hu M, Lin Y, Atteh LL, Fu W, Gao L, Bai M, Huang C, Yue P, et al: Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway. Front Oncol. 12:9829612022. View Article : Google Scholar : PubMed/NCBI | |
|
Adiguzel D and Celik-Ozenci C: FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy. Hum Reprod Update. 27:570–583. 2021.PubMed/NCBI | |
|
Xing YQ, Li A, Yang Y, Li XX, Zhang LN and Guo HC: The regulation of FOXO1 and its role in disease progression. Life Sci. 193:124–131. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Huang H and Tindall DJ: Dynamic FoxO transcription factors. J Cell Sci. 120:2479–2487. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Teaney NA and Cyr NE: FoxO1 as a tissue-specific therapeutic target for type 2 diabetes. Front Endocrinol (Lausanne). 14:12868382023. View Article : Google Scholar : PubMed/NCBI | |
|
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F and Qu F: Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway. J Ethnopharmacol. 318:1170252024. View Article : Google Scholar : PubMed/NCBI | |
|
Sun WL, He LY, Liang L, Liu SY, Luo J, Lv ML and Cai ZW: Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway. Apoptosis. 27:329–341. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M, Sun F, Zhang S, Zhang X, Sun Y, Yu T, Li Y, Jiang A, Qiao P, Ren C and Yang T: NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1. Cell Mol Life Sci. 81:2372024. View Article : Google Scholar : PubMed/NCBI | |
|
Nayak R, Chattopadhyay T and Mallick B: Identification of potential repurposed drugs for treating endometriosis-associated infertility among women. Chem Biol Interact. 365:1101102022. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, An M, Fu X, Meng X, Ma Y, Liu H, Li Q, Xu H and Chen J: Bushen Wenyang Huayu Decoction inhibits autophagy by regulating the SIRT1-FoXO-1 pathway in endometriosis rats. J Ethnopharmacol. 308:1162772023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Jiang L and Liu H: Forkhead Box Protein O1: Functional diversity and Post-Translational modification, a new therapeutic target? Drug Des Devel Ther. 15:1851–1860. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ebrahimnezhad M, Natami M, Bakhtiari GH, Tabnak P, Ebrahimnezhad N, Yousefi B and Majidinia M: FOXO1, a tiny protein with intricate interactions: Promising therapeutic candidate in lung cancer. Biomed Pharmacother. 69:1159002023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Zhou Y and Graves DT: FOXO transcription factors: Their clinical significance and regulation. Biomed Res Int. 2014:9253502014.PubMed/NCBI | |
|
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857–868. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Y, Yi L, Yang Y, Wu Z, Kong M, Kang Z and Yang Z: Acetylation of FOXO1 activates Bim expression involved in CVB3 induced cardiomyocyte apoptosis. Apoptosis. 29:1271–1287. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Otani T, Matsuda M, Mizokami A, Kitagawa N, Takeuchi H, Jimi E, Inai T and Hirata M: Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300. Cell Death Dis. 9:11942018. View Article : Google Scholar : PubMed/NCBI | |
|
Su RW, Strug MR, Joshi NR, Jeong JW, Miele L, Lessey BA, Young SL and Fazleabas AT: Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. J Clin Endocrinol Metab. 100:E433–E442. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yin X, Pavone ME, Lu Z, Wei J and Kim JJ: Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis. J Clin Endocrinol Metab. 97:E35–E43. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
An M, Fu X, Meng X, Liu H, Ma Y, Li Y, Li Q and Chen J: PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis. J Reprod Immunol. 162:1042132024. View Article : Google Scholar : PubMed/NCBI | |
|
Li MQ, Luo XZ, Meng YH, Mei J, Zhu XY, Jin LP and Li DJ: CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. Hum Reprod. 27:2107–2116. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857–868. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Ide H, Mizushima T, Jiang G, Goto T, Nagata Y, Teramoto Y, Inoue S, Li Y, Kashiwagi E, Baras AS, et al: FOXO1 as a tumor suppressor inactivated via AR/ERβ signals in urothelial cells. Endocr Relat Cancer. 27:231–244. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lengyel F, Vértes Z, Kovács KA, Környei JL, Sümegi B and Vértes M: Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus. Steroids. 72:422–428. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Retis-Resendiz AM, Gómez-Suárez SK, García-Gómez E and Vázquez-Martínez ER: Molecular basis of impaired decidualization in the eutopic endometrium of endometriosis patients. Cells. 14:3262025. View Article : Google Scholar : PubMed/NCBI | |
|
Pramanik KC, Fofaria NM, Gupta P and Srivastava SK: CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther. 13:687–698. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M, Zhang Q, Hu Y, Xu L, Jiang Y, Zhang C, Ding L, Jiang R, Sun J, Sun H and Yan G: miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation. Cell Death Dis. 8:e30882017. View Article : Google Scholar : PubMed/NCBI | |
|
Kayal RA, Siqueira M, Alblowi J, McLean J, Krothapalli N, Faibish D, Einhorn TA, Gerstenfeld LC and Graves DT: TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res. 25:1604–1615. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Xu JN, Zeng C, Zhou Y, Peng C, Zhou YF and Xue Q: Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation. J Clin Endocrinol Metab. 99:2795–2803. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rezk NA, Lashin MB and Sabbah NA: MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis. Noncoding RNA Res. 6:35–41. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kopp JB: Loss of Krüppel-like factor 6 cripples podocyte mitochondrial function. J Clin Invest. 125:968–971. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Shi J, Jing W, He Y and Huang Y: Decreased expression of KLF6 in ectopic endometrial stromal cells contributes to endometriosis progression by targeting CTNNB1. Cell Signal. 120:1112302024. View Article : Google Scholar : PubMed/NCBI | |
|
Tian F, Zhao J, Bu S, Teng H, Yang J, Zhang X, Li X and Dong L: KLF6 induces apoptosis in human lens epithelial cells through the ATF4-ATF3-CHOP axis. Drug Des Devel Ther. 14:1041–1055. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Meng F, Li J, Dong K, Bai R, Liu Q, Lu S, Liu Y, Wu D, Jiang C and Li W: Juan-tong-yin potentially impacts endometriosis pathophysiology by enhancing autophagy of endometrial stromal cells via unfolded protein reaction-triggered endoplasmic reticulum stress. J Ethnopharmacol. 325:1178592024. View Article : Google Scholar : PubMed/NCBI | |
|
Savitsky D, Tamura T, Yanai H and Taniguchi T: Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother. 5:489–510. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, He Y, Qu Y, Ren C, Wang X, Cheng Y, Sun L, Zhang X and Zhang G: Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis. Front Immunol. 14:11155042023. View Article : Google Scholar : PubMed/NCBI | |
|
Ke CY, Mei HH, Wong FH and Lo LJ: IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion. Sci Signal. 12:eaav76662019. View Article : Google Scholar : PubMed/NCBI | |
|
Ma X, Wang X, Dong Q, Pang H, Xu J and Shen J: Inhibition of KIF20A by transcription factor IRF6 affects the progression of renal clear cell carcinoma. Cancer Cell Int. 21:2462021. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Li J, Qu Y, Sun L, Zhao X, Wu H and Zhang G: Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis. J Immunol Res. 2023:29755812023. View Article : Google Scholar : PubMed/NCBI | |
|
Ma H, Sun X, Wang Y, Tian H, Lao K, Yan J and Diao X: Integrated analysis identified novel miRNAs and mRNA in endometriosis. Ginekol Pol. Sep 27–2022.doi: 10.5603/GP.a2022.0078 (Epub ahead of print). | |
|
Qiu B, Yuan P, Du X, Jin H, Du J and Huang Y: Hypoxia inducible factor-1α is an important regulator of macrophage biology. Heliyon. 9:e171672023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang F, Liu XL, Wang W, Dong HL, Xia YF, Ruan LP and Liu LP: Expression of MMIF, HIF-1α and VEGF in serum and endometrial tissues of patients with endometriosis. Curr Med Sci. 38:499–4504. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shi S, Ou X, Liu C, Wen H and Ke J: Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment. Front Immunol. 6:15492762025. View Article : Google Scholar : PubMed/NCBI | |
|
Corrado C and Fontana S: Hypoxia and HIF Signaling: One axis with divergent effects. Int J Mol Sci. 21:56112020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan L, Wang W, Zhang Y, Song E, Fan Y and Wei B: Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis. Biochimie. 123:130–137. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu H, Zhang Z, Xiong W, Zhang L, Xiong Y, Li N, He H, Du Y and Liu Y: Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis. Reproduction. 153:809–820. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lin H, Wang K, Yang J, Wang A, Deng J and Lin D: Donepezil promotes skin flap survival through activation of the HIF-1α/VEGF signalling pathway. Wound Repair Regen. 32:500–510. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Y, Dong Z and Liu K: Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery. J Exp Clin Cancer Res. 43:232024. View Article : Google Scholar : PubMed/NCBI | |
|
Fathi N, Rashidi G, Khodadadi A, Shahi S and Sharifi S: STAT3 and apoptosis challenges in cancer. Int J Biol Macromol. 117:993–1001. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gharibi T, Babaloo Z, Hosseini A, Abdollahpour-Alitappeh M, Hashemi V, Marofi F, Nejati K and Baradaran B: Targeting STAT3 in cancer and autoimmune diseases. Eur J Pharmacol. 878:1731072020. View Article : Google Scholar : PubMed/NCBI | |
|
Matsuzaki S, Pouly JL and Canis M: Persistent activation of signal transducer and activator of transcription 3 via Interleukin-6 trans-signaling is involved in fibrosis of endometriosis. Hum Reprod. 37:1489–1504. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Guo F, He Y, Fan Y, Du Z, Sun H, Feng Z and Xiong T: G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils. Mol Hum Reprod. 27:gaab0642021. View Article : Google Scholar : PubMed/NCBI | |
|
Kim BG, Yoo JY, Kim TH, Shin JH, Langenheim JF, Ferguson SD, Fazleabas AT, Young SL, Lessey BA and Jeong JW: Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis. Hum Reprod. 30:1069–1078. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Feng Y, Dong H and Zheng L: Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis. Pharm Biol. 61:666–673. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
As-Sanie S, Mackenzie SC, Morrison L, Schrepf A, Zondervan KT, Horne AW and Missmer SA: Endometriosis: A review. JAMA. 334:64–78. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Garvey M: Endometriosis: Future biological perspectives for diagnosis and treatment. Int J Mol Sci. 25:122422024. View Article : Google Scholar : PubMed/NCBI | |
|
Samimi M, Pourhanifeh MH, Mehdizadehkashi A, Eftekhar T and Asemi Z: The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression. J Cell Physiol. 234:19384–19392. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Adilbayeva A and Kunz J: Pathogenesis of endometriosis and endometriosis-associated cancers. Int J Mol Sci. 25:76242024. View Article : Google Scholar : PubMed/NCBI | |
|
Garcia-Velasco JA and Arici A: Apoptosis and the pathogenesis of endometriosis. Semin Reprod Med. 21:165–172. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Delbandi AA, Mahmoudi M, Shervin A, Heidari S, Kolahdouz-Mohammadi R and Zarnani AH: Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls. BMC Womens Health. 20:32020. View Article : Google Scholar : PubMed/NCBI | |
|
Bo C and Wang Y: Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review). Mol Med Rep. 29:432024. View Article : Google Scholar : PubMed/NCBI | |
|
Vissers G, Giacomozzi M, Verdurmen W, Peek R and Nap A: The role of fibrosis in endometriosis: A systematic review. Hum Reprod Update. 30:706–750. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Chang X, Zhang Y, Deng M, Yang R, Zhang J, Hao M and Miao J: OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7. Mol Hum Reprod. 31:gaaf0142025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao L, Gu C, Ye M, Zhang Z, Li L, Fan W and Meng Y: Integration analysis of microRNA and mRNA paired expression profiling identifies deregulated microRNA-transcription factor-gene regulatory networks in ovarian endometriosis. Reprod Biol Endocrinol. 16:42018. View Article : Google Scholar : PubMed/NCBI | |
|
Cong S, Guo Q, Cheng Y, Gao J, Sun L, Wang J, Wu H, Liang T and Zhang G: Identification and analyzation of differentially expressed transcription factors in endometriosis. Front Mol Biosci. 7:6144272020. View Article : Google Scholar : PubMed/NCBI | |
|
Geng R, Huang X, Li L and Guo X, Wang Q, Zheng Y and Guo X: Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets. Front Immunol. 13:10375042022. View Article : Google Scholar : PubMed/NCBI |
