Open Access

Role of the NLRP3 inflammasome in diabetes and its complications (Review)

  • Authors:
    • Xinyi Jiao
    • Guoqing Tian
  • View Affiliations

  • Published online on: August 19, 2025     https://doi.org/10.3892/mmr.2025.13657
  • Article Number: 292
  • Copyright: © Jiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes and its complications are systemic metabolic disorders triggered by chronic hyperglycemia, with the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome carrying out a central role in disease progression. Activation of the NLRP3 inflammasome is involved not only in the onset of diabetes but also in its complications, including cardiovascular disease, nephropathy and retinopathy. The present review outlines the core mechanisms of the NLRP3 inflammasome and its specific contributions to diabetes and associated conditions. Additionally, emerging therapeutic strategies that target the NLRP3 inflammasome were explored, offering novel insights into the management of diabetes and its associated complications.
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November-2025
Volume 32 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiao X and Tian G: Role of the NLRP3 inflammasome in diabetes and its complications (Review). Mol Med Rep 32: 292, 2025.
APA
Jiao, X., & Tian, G. (2025). Role of the NLRP3 inflammasome in diabetes and its complications (Review). Molecular Medicine Reports, 32, 292. https://doi.org/10.3892/mmr.2025.13657
MLA
Jiao, X., Tian, G."Role of the NLRP3 inflammasome in diabetes and its complications (Review)". Molecular Medicine Reports 32.5 (2025): 292.
Chicago
Jiao, X., Tian, G."Role of the NLRP3 inflammasome in diabetes and its complications (Review)". Molecular Medicine Reports 32, no. 5 (2025): 292. https://doi.org/10.3892/mmr.2025.13657