Open Access

Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review)

  • Authors:
    • Mengmeng Yao
    • Chuqi Liu
    • Huiyu Ping
    • Kaidi Meng
    • Xinru Li
    • Qingxin Li
    • Yuanmin Qi
    • Ziming Zhu
    • Li Zhang
    • Aizhong Han
  • View Affiliations

  • Published online on: August 21, 2025     https://doi.org/10.3892/mmr.2025.13660
  • Article Number: 295
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometrial cancer (EC) is a common gynecologic malignancy that often exhibits molecular features such as extensive somatic copy number alterations, microsatellite instability and frequent TP53 mutations, which considerably affect the physical and mental well‑being of women. The Fanconi anemia (FA) pathway is a DNA damage repair pathway involving multiple FA genes that play crucial roles in DNA damage repair as well as the maintenance of genome stability. Abnormalities in FA, such as deletions or mutations, may lead to defects in DNA damage repair, resulting in increased genomic instability and/or an abnormal cell cycle, ultimately leading to EC. This comprehensive review provides a systematic summary of EC‑related FA genes, elucidates the roles of various FA genes in EC and further speculates on their related mechanisms to facilitate the development of targeted therapies that specifically target key genes, leading to a more accurate and efficient treatment for EC. The present review searched PubMed and Google Scholar for articles published in English up to June 2025 using keywords such as Fanconi anemia pathway, 22 FA genes (FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, FANCN/PALB2, FANCO/RAD51C, FANCP/SLX4, FANCQ/XPF, FANCR/RAD51, FANCS/BRCA1, FANCT/UBE2T, FANCU/XRCC2, FANCV/REV7, FANCW/RFWD3), endometrial cancer (type I: Endometrioid adenocarcinoma; Type II Uterine serous carcinoma, clear‑cell carcinoma, carcinosarcoma), somatic copy number alterations, microsatellite instability, TP53 mutations, pathogenesis, genomic instability, target therapy.
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November-2025
Volume 32 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yao M, Liu C, Ping H, Meng K, Li X, Li Q, Qi Y, Zhu Z, Zhang L, Han A, Han A, et al: Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review). Mol Med Rep 32: 295, 2025.
APA
Yao, M., Liu, C., Ping, H., Meng, K., Li, X., Li, Q. ... Han, A. (2025). Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review). Molecular Medicine Reports, 32, 295. https://doi.org/10.3892/mmr.2025.13660
MLA
Yao, M., Liu, C., Ping, H., Meng, K., Li, X., Li, Q., Qi, Y., Zhu, Z., Zhang, L., Han, A."Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review)". Molecular Medicine Reports 32.5 (2025): 295.
Chicago
Yao, M., Liu, C., Ping, H., Meng, K., Li, X., Li, Q., Qi, Y., Zhu, Z., Zhang, L., Han, A."Potential role of Fanconi anemia pathway in the pathogenesis of endometrial cancer (Review)". Molecular Medicine Reports 32, no. 5 (2025): 295. https://doi.org/10.3892/mmr.2025.13660