Open Access

The role of Na,K‑ATPase in lung diseases (Review)

  • Authors:
    • Zhenyu Liu
    • Tingyan Dong
    • Fei Li
    • Chunmei He
    • Weizhen Zhang
    • Biyun Li
  • View Affiliations

  • Published online on: August 27, 2025     https://doi.org/10.3892/mmr.2025.13665
  • Article Number: 300
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Na,K‑ATPase, commonly referred to as the sodium pump, is known for its essential function as an ion pump, which is key for transporting Na+ and K+ across plasma cell membranes. Additionally, Na,K‑ATPase has multiple biological functions, independent of ion pumping, which are involved in regulating cell proliferation, apoptosis, differentiation and other processes associated with the development and progression of various diseases; particularly cancer, cardiovascular diseases, nervous system diseases, kidney diseases and lung diseases. As a potential therapeutic target, Na,K‑ATPase may represent a novel strategy for treating these diseases in the future. The present review aims to summarize the role of Na,K‑ATPase in lung diseases.
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November-2025
Volume 32 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Dong T, Li F, He C, Zhang W and Li B: The role of Na,K‑ATPase in lung diseases (Review). Mol Med Rep 32: 300, 2025.
APA
Liu, Z., Dong, T., Li, F., He, C., Zhang, W., & Li, B. (2025). The role of Na,K‑ATPase in lung diseases (Review). Molecular Medicine Reports, 32, 300. https://doi.org/10.3892/mmr.2025.13665
MLA
Liu, Z., Dong, T., Li, F., He, C., Zhang, W., Li, B."The role of Na,K‑ATPase in lung diseases (Review)". Molecular Medicine Reports 32.5 (2025): 300.
Chicago
Liu, Z., Dong, T., Li, F., He, C., Zhang, W., Li, B."The role of Na,K‑ATPase in lung diseases (Review)". Molecular Medicine Reports 32, no. 5 (2025): 300. https://doi.org/10.3892/mmr.2025.13665