Open Access

N6‑methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review)

  • Authors:
    • Man Xu
    • Fanglei Yang
    • Huan Chen
    • Feiyun Jiang
  • View Affiliations

  • Published online on: July 14, 2025     https://doi.org/10.3892/ol.2025.15188
  • Article Number: 442
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is one of the most common malignant tumors among women worldwide. Its primary etiology is closely associated with human papillomavirus infection, which poses a serious threat to the health of women. N6‑methyladenosine (m6A) modifications notably affect the biological characteristics of tumor cells, such as their proliferation, metastasis and chemoresistance, by regulating the stability, translation and degradation of RNA. It also serves an important regulatory role in the pathogenesis of cervical cancer. The present review details the mechanisms underlying m6A modification in cervical cancer and analyzes its impact on tumor progression. Moreover, it explores the potential clinical applications of m6A modification as a biomarker and therapeutic target to provide new insights and evidence regarding the early diagnosis and individualized treatment of patients with cervical cancer.
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September-2025
Volume 30 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu M, Yang F, Chen H and Jiang F: N6‑methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review). Oncol Lett 30: 442, 2025.
APA
Xu, M., Yang, F., Chen, H., & Jiang, F. (2025). N6‑methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review). Oncology Letters, 30, 442. https://doi.org/10.3892/ol.2025.15188
MLA
Xu, M., Yang, F., Chen, H., Jiang, F."N6‑methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review)". Oncology Letters 30.3 (2025): 442.
Chicago
Xu, M., Yang, F., Chen, H., Jiang, F."N6‑methyladenosine in cervical carcinogenesis: Mechanistic insights and therapeutic perspectives (Review)". Oncology Letters 30, no. 3 (2025): 442. https://doi.org/10.3892/ol.2025.15188