Choroidal metastasis as the first sign of small cell lung cancer: A case report

Wei,Keke; Liu,Fang; Ning,Cheng; Zhang,Yingbo; Hu,Chunmei

doi:10.3892/ol.2025.15197

Choroidal metastasis as the first sign of small cell lung cancer: A case report

Authors:
- Keke Wei
- Fang Liu
- Cheng Ning
- Yingbo Zhang
- Chunmei Hu
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Affiliations: Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin 130000, P.R. China
Published online on: July 18, 2025 https://doi.org/10.3892/ol.2025.15197
Article Number: 451
Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastases in the choroid originating from small cell lung cancer (SCLC) remain rare. The diagnosis of ocular metastases and primary lung tumors in individuals with SCLC can be challenging and time‑consuming, particularly when their first symptoms present as ocular. The treatment of patients with ocular metastases of lung cancer is another clinical challenge in terms of primary tumor control and metastasis suppression. The current study presents the case of a 62‑year‑old man admitted to The Second Hospital of Jilin University (Jilin, China) for blurred vision. Based on subsequent clinical and pathological features of the patient, choroidal metastasis was suspected. Upon examination, the patient was diagnosed with serous retinal detachment, pleural effusion, choroidal metastases and SCLC of the right lung. Patients with the aforementioned condition receive chemotherapy and radiotherapy. First‑line chemotherapy regimens consisted of etoposide and nedaplatin, while second‑line regimens consisted of liposomal paclitaxel combined with lobaplatin. The condition of the patient was controlled during the first treatment period, which led to a temporary improvement in quality of life. However, the disease rapidly progressed, and the patient declined further treatment and ultimately succumbed to his illness. Visual symptoms may be the first indication of malignant tumors; therefore, ocular symptoms should be vigilantly monitored in patients diagnosed with malignant tumors. Furthermore, palliative care, psychological support and socioeconomic assistance are key to the quality of life of patients. Adoption of a patient‑centered approach to provide comfort can also optimize treatment outcomes and improve the quality of life of patients.

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