Open Access

Histomorphological and molecular characteristics of liposarcoma (Review)

  • Authors:
    • Ery Kus Dwianingsih
    • Rheza Gandi Bawono
    • Ade Saputri
    • Rusdy Ghazali Malueka
    • Yuni Artha Prabowo Putro
    • Sumadi Lukman Anwar
    • Irianiwati Widodo
  • View Affiliations

  • Published online on: July 21, 2025     https://doi.org/10.3892/ol.2025.15200
  • Article Number: 454
  • Copyright: © Dwianingsih et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liposarcomas represent the most prevalent subtype of soft‑tissue sarcomas, comprising 15‑20% of all documented cases. However, sarcomas demonstrate notable clinical and pathological variability, which complicates the processes of diagnosis and treatment. Histomorphological analysis can produce inconsistent results due to inter‑examiner variability, which highlights the need for more reliable biomarkers. Genetic and epigenetic alterations may delineate the biological behavior of liposarcomas and assist in the prediction of liposarcoma prognosis. The present review highlights the related genomic alterations in sarcoma and their associations with relevant histomorphology, predilection, targeted therapy and prognosis. Well‑differentiated and dedifferentiated liposarcomas exhibit amplified genes, MDM2 proto‑oncogene and cyclin‑dependent kinase 4, which are potential targets for therapy. Myxoid liposarcoma, characterized by the chromosomal translocations t(12;16) with fused in liposarcoma‑DNA damage‑inducible transcript 3 protein (DDIT3) fusion and t(12;22) with Ewing sarcoma RNA‑binding protein 1‑DDIT3 fusion, demonstrate a favorable response to treatment; however, myxoid liposarcoma displays elevated recurrence rates. Moreover, the complex karyotype and lack of specificity in pleomorphic liposarcoma are associated with poor treatment outcomes and increased recurrence rates. Integration of morphological features with molecular biomarkers may potentially enhance diagnosis, facilitate targeted therapies and improve sarcoma prognosis in the future.
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October-2025
Volume 30 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dwianingsih EK, Bawono RG, Saputri A, Malueka RG, Putro YA, Anwar SL and Widodo I: Histomorphological and molecular characteristics of liposarcoma (Review). Oncol Lett 30: 454, 2025.
APA
Dwianingsih, E.K., Bawono, R.G., Saputri, A., Malueka, R.G., Putro, Y.A., Anwar, S.L., & Widodo, I. (2025). Histomorphological and molecular characteristics of liposarcoma (Review). Oncology Letters, 30, 454. https://doi.org/10.3892/ol.2025.15200
MLA
Dwianingsih, E. K., Bawono, R. G., Saputri, A., Malueka, R. G., Putro, Y. A., Anwar, S. L., Widodo, I."Histomorphological and molecular characteristics of liposarcoma (Review)". Oncology Letters 30.4 (2025): 454.
Chicago
Dwianingsih, E. K., Bawono, R. G., Saputri, A., Malueka, R. G., Putro, Y. A., Anwar, S. L., Widodo, I."Histomorphological and molecular characteristics of liposarcoma (Review)". Oncology Letters 30, no. 4 (2025): 454. https://doi.org/10.3892/ol.2025.15200