Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report

  • Authors:
    • Ioannis Ntanasis‑Stathopoulos
    • Ilias Katsadouros
    • Panagiotis Malandrakis
    • Erasmia Psimenou
    • Meletios-Athanasios Dimopoulos
    • Maria Gavriatopoulou
  • View Affiliations

  • Published online on: August 8, 2025     https://doi.org/10.3892/ol.2025.15220
  • Article Number: 474
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Teclistamab, a B‑cell maturation antigen‑targeting bispecific antibody, offers a promising treatment option for relapsed/refractory multiple myeloma (RRMM), even in patients with severe renal impairment. The present study describes the case of a 47‑year‑old woman with RRMM who achieved minimal residual disease negativity and dialysis independence following teclistamab treatment. Despite prior resistance to multiple therapies, including an anti‑CD38 monoclonal antibody (daratumumab), two proteasome inhibitors (bortezomib and carfilzomib), an immunomodulatory drug (lenalidomide), an exportin 1 inhibitor (selinexor), a BCL‑2 inhibitor (venetoclax) and dexamethasone, and post‑autologous stem cell transplantation relapse, teclistamab induced a deep hematological response. Cytokine release syndrome was manageable and no major complications occurred. The present case highlights the feasibility and effectiveness of teclistamab in patients with end‑stage renal disease.
View Figures
View References

Related Articles

Journal Cover

October-2025
Volume 30 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ntanasis‑Stathopoulos I, Katsadouros I, Malandrakis P, Psimenou E, Dimopoulos M and Gavriatopoulou M: Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncol Lett 30: 474, 2025.
APA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., & Gavriatopoulou, M. (2025). Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report. Oncology Letters, 30, 474. https://doi.org/10.3892/ol.2025.15220
MLA
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30.4 (2025): 474.
Chicago
Ntanasis‑Stathopoulos, I., Katsadouros, I., Malandrakis, P., Psimenou, E., Dimopoulos, M., Gavriatopoulou, M."Dialysis independence for a young patient with refractory multiple myeloma treated with teclistamab: A case report". Oncology Letters 30, no. 4 (2025): 474. https://doi.org/10.3892/ol.2025.15220