Primary cutaneous follicular center lymphoma of the upper arm: A case report

Yu,Xintong; Wang,Yi; Cui,Yan; Cao,Xiaoli

doi:10.3892/ol.2025.15223

Primary cutaneous follicular center lymphoma of the upper arm: A case report

Authors:
- Xintong Yu
- Yi Wang
- Yan Cui
- Xiaoli Cao
View Affiliations

Affiliations: Department of Medical Imaging, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China, Department of Medical Imaging, Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Ultrasound, The Affiliated Yantai Yuhuanding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China
Published online on: August 11, 2025 https://doi.org/10.3892/ol.2025.15223
Article Number: 477
Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is unique in its biological behavior and molecular features, and it is also relatively rare. The present study reports a case of PCFCL in a young male patient, aged 32 years, whose primary skin lesion was located in the left upper arm. A skin biopsy confirmed that the dermal tissue of the patient's skin was affected by PCFCL. The patient was treated with radiation therapy and the mass was significantly reduced, with a resultant good prognosis. This case of a young patient with PCFCL is reported in order to provide a reference for the diagnostic segment of this disease.

View Figures

View References

1	Kim MJ, Hong ME, Maeng CH, Jung HA, Hong JY, Choi MK, Kim SJ, Ko YH and Kim WS: Clinical features and treatment outcomes of primary cutaneous B-cell lymphoma: A single-center analysis in South Korea. Int J Hematol. 101:273–278. 2015. View Article : Google Scholar : PubMed/NCBI
2	Swerdlow SH, Campo E, Pileri SA, Harris NA, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe E: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI
3	Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C and Myskowski PL: Primary cutaneous B-cell lymphomas: Part I. Clinical features, diagnosis, and classification. J Am Acad Dermatol. 69:329.e1–e13. 341–342. 2023. View Article : Google Scholar : PubMed/NCBI
4	Korgavkar K and Weinstock MA: Changing incidence trends of cutaneous B-cell lymphoma. J Invest Dermatol. 134:840–842. 2014. View Article : Google Scholar : PubMed/NCBI
5	Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH and Jaffe ES: The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 133:1703–1714. 2019. View Article : Google Scholar : PubMed/NCBI
6	Correia E, Cha J, Krishnasamy S, Donnell MO, 'Shi W, Porcu P and Nikbakht N: A case series of primary cutaneous B-cell lymphomas with atypical presentations: Diagnostic and therapeutic challenges. Haematologica. 107:1014–1016. 2022. View Article : Google Scholar : PubMed/NCBI
7	Niu WY, Yan XS, Qiao H, Sun YJ, Gu HY, Li GL, Cui ZG and Du J: An adolescent with primary cutaneous follicle center lymphoma: A case report and literature review. Front Oncol. 13:12737192023. View Article : Google Scholar : PubMed/NCBI
8	Wu X and Lei L: Ultrasonic manifestations of primary axillary cutaneous follicular central lymphoma in the case. Chin J Ultras Med. 38:4692022.(In Chinese).
9	Mandava A, Koppula V, Wortsman X, Catalano O and Alfageme F: The clinical value of imaging in primary cutaneous lymphomas: Role of high resolution ultrasound and PET-CT. Brit J Radiol. 92:201809042019. View Article : Google Scholar : PubMed/NCBI
10	Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP and Beylot-Barry M: Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with follicular lymphoma presenting as primary skin lesions. Am J Clin Pathol. 143:362–373. 2015. View Article : Google Scholar : PubMed/NCBI
11	Hristov AC, Tejasvi T and Wilcox RA: Cutaneous B-cell lymphomas: 2023 Update on diagnosis, risk-stratification, and management. Am J Hematol. 98:1326–1332. 2023. View Article : Google Scholar : PubMed/NCBI
12	Saksena A, Jain A, Pack SD, Kim J, Lee I, Tyagi M, Xi L, Pittaluga S, Raffeld M and Jaffe ES: Follicle center lymphoma (FCL) of the lower female genital tract (LFGT): A novel variant of primary cutaneous follicle center lymphoma (PCFCL). Am J Surg Pathol. 47:409–419. 2023. View Article : Google Scholar : PubMed/NCBI
13	Al Harbi SM, Al Natour S, Al Saif NM, Al Saif N and Al Bayat MI: Primary cutaneous follicle center lymphoma presenting as a solitary nodule on the forearm of an adolescent girl: A case report and literature review. Clin Cosmet Investig Dermatol. 16:167–172. 2023. View Article : Google Scholar : PubMed/NCBI
14	Ceppi F, Pope E, Ngan B and Abla O: Primary cutaneous lymphomas in children and adolescents. Pediatr Blood Cancer. 63:1886–1894. 2016. View Article : Google Scholar : PubMed/NCBI
15	Uccella S, Goteri G, Maiorana A, Donati V, Tibiletti MG, Magnoli F, Facchi S, Merchiori D, Morsia E, Papotti R, et al: Clinicopathological, cytogenetic, and molecular profiles of primary cutaneous diffuse large B-cell lymphomas. Hum Pathol. 136:44–55. 2023. View Article : Google Scholar : PubMed/NCBI
16	Olsen EA: Evaluation, diagnosis, and staging of cutaneous lymphoma. Dermatol Clin. 33:643–654. 2015. View Article : Google Scholar : PubMed/NCBI
17	Vitiello P, Sica A, Ronchi A, Caccavale S, Franco R and Argenziano G: Primary cutaneous B-cell lymphomas: An update. Front Oncol. 10:6512020. View Article : Google Scholar : PubMed/NCBI
18	Specht L, Dabaja B, Illidge T, Wilson LD and Hoppe RT; International Lymphoma Radiation Oncology Group, : Modern radiation therapy for primary cutaneous lymphomas: Field and dose guidelines from the international lymphoma radiation oncology Group. Int J Radiat Oncol Biol Phys. 92:32–39. 2015. View Article : Google Scholar : PubMed/NCBI
19	Wang S, Perlmutter JW, Johnston J, Nugent Z and Wiseman M: Rituximab treatment of primary cutaneous follicle center lymphoma: A retrospective review. J Cutan Med Surg. 26:604–612. 2022. View Article : Google Scholar : PubMed/NCBI