Open Access

Association between immune‑related adverse events and therapeutic outcomes in patients with advanced non‑small cell lung cancer treated with pembrolizumab: A retrospective study

  • Authors:
    • Tabarak J. Talab
    • Farha A. Ali Shafi
    • Saba M. Jasim
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  • Published online on: June 26, 2025     https://doi.org/10.3892/wasj.2025.370
  • Article Number: 82
  • Copyright : © Talab et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Several studies have indicated that the emergence of immune‑related adverse events (irAEs) in patients receiving immunotherapy is a positive prognostic indicator. The aim of the present study was to assess the influence of irAEs on the clinical outcomes of patients with advanced stage non‑small cell lung cancer (NSCLC), particularly the prognostic importance of irAEs. For this purpose, 60 patients with NSCLC were enrolled retrospectively; the patients received immunotherapy between January, 2020 and April, 2022. Clinical outcomes and progression‑free survival (PFS) were compared between individuals with irAEs and those without. Of note, more than half of the patients (55%) developed irAEs. The median PFS of the patients with irAEs was significantly longer than that of the patients without irAEs (12.19 vs. 5.48 months). Furthermore, as regards the clinical outcomes, the disease control rate was significantly increased in the group with irAEs (72.7 vs. to 27.3%; P=0.033). On the whole, the present study indicated that patients with advanced stage NSCLC who experienced irAEs exhibited improved clinical outcomes following immunotherapy compared to those without irAEs. This underscores the prospective application of the development of irAEs as a clinical biomarker for immunotherapy‑treated advanced stage NSCLC.
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September-October 2025
Volume 7 Issue 5

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Spandidos Publications style
Talab TJ, Shafi FA and Jasim SM: Association between immune‑related adverse events and therapeutic outcomes in patients with advanced non‑small cell lung cancer treated with pembrolizumab: A retrospective study. World Acad Sci J 7: 82, 2025.
APA
Talab, T.J., Shafi, F.A., & Jasim, S.M. (2025). Association between immune‑related adverse events and therapeutic outcomes in patients with advanced non‑small cell lung cancer treated with pembrolizumab: A retrospective study. World Academy of Sciences Journal, 7, 82. https://doi.org/10.3892/wasj.2025.370
MLA
Talab, T. J., Shafi, F. A., Jasim, S. M."Association between immune‑related adverse events and therapeutic outcomes in patients with advanced non‑small cell lung cancer treated with pembrolizumab: A retrospective study". World Academy of Sciences Journal 7.5 (2025): 82.
Chicago
Talab, T. J., Shafi, F. A., Jasim, S. M."Association between immune‑related adverse events and therapeutic outcomes in patients with advanced non‑small cell lung cancer treated with pembrolizumab: A retrospective study". World Academy of Sciences Journal 7, no. 5 (2025): 82. https://doi.org/10.3892/wasj.2025.370