Co‑occurrence of endometriosis with psoriasis and psoriatic arthritis: Genetic insights (Review)

Goulielmos,George N.; Tarlatzi,Theoni B.; Grimbizis,Grigoris F.; Spandidos,Demetrios A.; Niewold,Timothy B.; Bertsias,George; Tarlatzis,Basil C.; Zervou,Maria I.

doi:10.3892/etm.2025.12921

Co‑occurrence of endometriosis with psoriasis and psoriatic arthritis: Genetic insights (Review)

Authors:
- George N. Goulielmos
- Theoni B. Tarlatzi
- Grigoris F. Grimbizis
- Demetrios A. Spandidos
- Timothy B. Niewold
- George Bertsias
- Basil C. Tarlatzis
- Maria I. Zervou
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Affiliations: Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71403 Heraklion, Greece, Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Barbara Volcker Center for Women and Rheumatic Disease, New York, NY 10021, USA, Rheumatology and Clinical Immunology, School of Medicine, University of Crete, 71403 Heraklion, Greece
Published online on: July 10, 2025 https://doi.org/10.3892/etm.2025.12921
Article Number: 171
Copyright: © Goulielmos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunological factors appear to play an important role in the development of endometriosis, as evidenced by the aberrant functioning of immune cells often observed in affected women. Although endometriosis is not classified as an autoimmune disease, individuals with the condition show a higher tendency to develop various autoimmune disorders as comorbidities. There appears to be a bidirectional association between laparoscopically confirmed endometriosis and diagnosed psoriasis (PS) and psoriatic arthritis (PsA). Endometriosis is a chronic, complex, estrogen‑dependent and progressive gynecological disorder, characterized by the growth of endometrial tissue outside the uterine cavity. PS is an autoimmune, T‑cell‑mediated chronic inflammatory and proliferative skin disease, characterized by focal formation of inflamed, erythematous, raised plaques that shed scales derived from excessive growth of skin epithelial cells. PsA is a seronegative chronic inflammatory joint disease that is associated with PS, characterized by inflammatory changes in attachments of articular capsules, tendons, and ligaments to bone surface. The co‑occurrence of endometriosis with PS and PsA raises some intriguing points regarding their possible shared genetic background. In the context of the present study, an extensive review of the current literature was conducted to identify shared genetics factors and shed light into the underlying pathogenetic mechanisms.

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