Open Access

Pulmonary angiosarcoma in an HIV‑positive patient presenting with hemoptysis and multisystem involvement: Report of a rare case

  • Authors:
    • Geran Maule
    • Saar Peles
    • Hisham Husham
    • Mohammad Khraisat
    • Abdallah Rayyan
    • Luis Javier
  • View Affiliations

  • Published online on: August 19, 2025     https://doi.org/10.3892/mi.2025.261
  • Article Number: 62
  • Copyright : © Maule et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Pulmonary angiosarcoma is a rare, aggressive malignancy often mimicking other lung cancers. The present study describes the case of a 36‑year‑old male patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy who developed severe hemoptysis and respiratory distress, initially attributing his symptoms to mold exposure. Imaging revealed bilateral pulmonary nodules surrounded by ground‑glass (suggestive of hemorrhagic lesions), and a biopsy confirmed stage IV pulmonary angiosarcoma. Immunohistochemical staining yielded positive results for ERG, CD31, CD34 and CD117, and echocardiography identified a large tricuspid valve mass, suggesting metastatic disease. He was commenced on paclitaxel treatment, but switched to doxorubicin following an infusion reaction. His course was complicated by recurrent hemothorax and pericardial effusions, requiring thoracentesis, chest tube placement and pericardiocentesis. Due to disease progression and frequent readmissions, he ultimately opted for hospice care. The case described herein illustrates the diagnostic complexity of pulmonary angiosarcoma in the setting of HIV and highlights the poor prognosis associated with extensive pulmonary and cardiac involvement.
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November-December 2025
Volume 5 Issue 6

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Spandidos Publications style
Maule G, Peles S, Husham H, Khraisat M, Rayyan A and Javier L: Pulmonary angiosarcoma in an HIV‑positive patient presenting with hemoptysis and multisystem involvement: Report of a rare case. Med Int 5: 62, 2025.
APA
Maule, G., Peles, S., Husham, H., Khraisat, M., Rayyan, A., & Javier, L. (2025). Pulmonary angiosarcoma in an HIV‑positive patient presenting with hemoptysis and multisystem involvement: Report of a rare case. Medicine International, 5, 62. https://doi.org/10.3892/mi.2025.261
MLA
Maule, G., Peles, S., Husham, H., Khraisat, M., Rayyan, A., Javier, L."Pulmonary angiosarcoma in an HIV‑positive patient presenting with hemoptysis and multisystem involvement: Report of a rare case". Medicine International 5.6 (2025): 62.
Chicago
Maule, G., Peles, S., Husham, H., Khraisat, M., Rayyan, A., Javier, L."Pulmonary angiosarcoma in an HIV‑positive patient presenting with hemoptysis and multisystem involvement: Report of a rare case". Medicine International 5, no. 6 (2025): 62. https://doi.org/10.3892/mi.2025.261