Open Access

Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review)

  • Authors:
    • Rongxiu Huo
    • Chengcheng Wei
    • Yanting Yang
    • Yang Yang
    • Xiaocong Huo
    • Bangqin Wang
    • Danli Meng
    • Yijia Huang
    • Rongjun Huang
    • Jinying Lin
    • Xinxiang Huang
  • View Affiliations

  • Published online on: September 2, 2025     https://doi.org/10.3892/mmr.2025.13670
  • Article Number: 305
  • Copyright: © Huo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized primarily by arterial and/or venous thrombosis, obstetric complications and persistent positivity for antiphospholipid antibodies (aPLs). It has been proposed that the pathogenesis of APS is closely associated with vascular endothelial cell activation, complement activation and platelet activation. Notably, APS may be key to understanding the relationship between innate immune cells, and thrombosis and obstetric complications. Monocytes are activated by aPLs, adopting a pro‑inflammatory and pro‑coagulant phenotype, and producing inflammatory cytokines; however, the exact mechanisms of action of monocytes in APS remain unclear. Monocytes may act as an intermediary, triggering immune dysregulation, closely linking them to thrombosis and obstetric complications. Therefore, a better understanding of the potential pathogenic role of monocytes in APS is required, which could assist clinicians in gaining deeper insights into the pathogenesis of APS and identifying new therapeutic targets. This may provide new options for the management of APS. Therefore, the present study aimed to review monocytes and their role in APS.
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November-2025
Volume 32 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Huo R, Wei C, Yang Y, Yang Y, Huo X, Wang B, Meng D, Huang Y, Huang R, Lin J, Lin J, et al: Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review). Mol Med Rep 32: 305, 2025.
APA
Huo, R., Wei, C., Yang, Y., Yang, Y., Huo, X., Wang, B. ... Huang, X. (2025). Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review). Molecular Medicine Reports, 32, 305. https://doi.org/10.3892/mmr.2025.13670
MLA
Huo, R., Wei, C., Yang, Y., Yang, Y., Huo, X., Wang, B., Meng, D., Huang, Y., Huang, R., Lin, J., Huang, X."Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review)". Molecular Medicine Reports 32.5 (2025): 305.
Chicago
Huo, R., Wei, C., Yang, Y., Yang, Y., Huo, X., Wang, B., Meng, D., Huang, Y., Huang, R., Lin, J., Huang, X."Role of monocytes in the pathogenesis of antiphospholipid syndrome and potential therapeutic targets (Review)". Molecular Medicine Reports 32, no. 5 (2025): 305. https://doi.org/10.3892/mmr.2025.13670