Open Access

Effect of deubiquitinases in head and neck squamous cell carcinoma (Review)

  • Authors:
    • Jiahui Wang
    • Liangpei Wu
    • Zhifeng Tian
    • Jun Chen
  • View Affiliations

  • Published online on: April 23, 2025     https://doi.org/10.3892/ol.2025.15053
  • Article Number: 307
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

SCC includes nasopharyngeal, laryngeal and oral cancers, and its pathogenesis is influenced by various factors. As an essential part of the ubiquitin (Ub)‑proteasome system (UPS), deubiquitinating enzymes (DUBs) maintain the homeostasis of Ub molecules and influence the physiological functions of cells and disease processes by removing ubiquitinated proteins. Accumulating evidence has confirmed that the aberrant expression of DUBs is involved in cell proliferation, metastasis, and apoptosis during the development of HNSCC, with some acting as oncogenes and others as tumor‑suppressor genes. In this review, the DUBs implicated in HNSCC were summarized and the mechanisms underlying abnormal DUBs expression in signaling pathways were discussed. In addition, given the important role of DUBs in tumorigenesis, recent studies were reviewed and agonists and inhibitors of DUBs were summarized to identify more effective therapeutic strategies.
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June-2025
Volume 29 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang J, Wu L, Tian Z and Chen J: Effect of deubiquitinases in head and neck squamous cell carcinoma (Review). Oncol Lett 29: 307, 2025.
APA
Wang, J., Wu, L., Tian, Z., & Chen, J. (2025). Effect of deubiquitinases in head and neck squamous cell carcinoma (Review). Oncology Letters, 29, 307. https://doi.org/10.3892/ol.2025.15053
MLA
Wang, J., Wu, L., Tian, Z., Chen, J."Effect of deubiquitinases in head and neck squamous cell carcinoma (Review)". Oncology Letters 29.6 (2025): 307.
Chicago
Wang, J., Wu, L., Tian, Z., Chen, J."Effect of deubiquitinases in head and neck squamous cell carcinoma (Review)". Oncology Letters 29, no. 6 (2025): 307. https://doi.org/10.3892/ol.2025.15053