Open Access

SENP1: A perspective from immune cells to disease (Review)

  • Authors:
    • Xiaofang Feng
    • Guoyu Wu
    • Qiyan Zeng
  • View Affiliations

  • Published online on: July 15, 2025     https://doi.org/10.3892/or.2025.8947
  • Article Number: 114
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Small ubiquitin‑like modifier (SUMO) is a ubiquitin‑like protein that modifies target proteins across various eukaryotic subcellular structures. This process, known as SUMOylation, has been established as an essential regulatory mechanism that affects both the activity and positioning of proteins, maintaining cellular homeostasis. SUMOylation and deSUMOylation are reversible post‑translational modification processes mediated by SUMO proteins and SUMO/sentrin‑specific proteases (SENPs). The human SENP family comprises six members, each characterized by unique cellular localization and substrate specificity. The present review primarily summarizes the role and mechanisms of SENP1 in the development and maturation of immune cells, including lymphocytes, macrophages and erythrocytes, as well as its involvement in tumor cell invasion, metastasis, angiogenesis and resistance to pharmacological therapies. In addition, the introduction of SENP1 inhibitors as a therapeutic approach for cancer treatment is explored. Overall, the present study aimed to offer theoretical insights into cancer therapy strategies that target SENP1.
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September-2025
Volume 54 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Feng X, Wu G and Zeng Q: SENP1: A perspective from immune cells to disease (Review). Oncol Rep 54: 114, 2025.
APA
Feng, X., Wu, G., & Zeng, Q. (2025). SENP1: A perspective from immune cells to disease (Review). Oncology Reports, 54, 114. https://doi.org/10.3892/or.2025.8947
MLA
Feng, X., Wu, G., Zeng, Q."SENP1: A perspective from immune cells to disease (Review)". Oncology Reports 54.3 (2025): 114.
Chicago
Feng, X., Wu, G., Zeng, Q."SENP1: A perspective from immune cells to disease (Review)". Oncology Reports 54, no. 3 (2025): 114. https://doi.org/10.3892/or.2025.8947