Open Access

Potential therapeutic target in oncology: Protein palmitoylation (Review)

  • Authors:
    • Shiping Hao
    • Yongming Mei
    • Shaolin Chen
    • Jing Liu
    • Yao Zhang
    • Zhengfeng Zhu
    • Kangjia Zuo
  • View Affiliations

  • Published online on: July 16, 2025     https://doi.org/10.3892/or.2025.8950
  • Article Number: 117
  • Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Post‑translational modifications (PTMs) of proteins, by altering the structural conformation of precursor polypeptides, play an indispensable role in augmenting the diversity and stability of the proteome. PTMs exert profound influence on various hallmarks of tumor biology, including cellular proliferation, apoptosis, angiogenesis and metastatic dissemination. Accordingly, advancing our understanding of PTMs holds substantial promise for broadening the therapeutic landscape of oncology. Among these modifications, palmitoylation, a reversible lipid‑based PTM, critically modulates protein stability, membrane localization, protein‑protein interactions and signal transduction cascades. Dysregulation of palmitoylation has been increasingly implicated in tumorigenesis, suggesting its aberrant forms as putative targets for therapeutic intervention. The present review delineates the biochemical mechanisms underlying protein palmitoylation and synthesizes current insights into its multifaceted roles in tumor progression, immune modulation and metabolic regulation, thereby offering novel perspectives for the development of targeted cancer therapies.
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October-2025
Volume 54 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Hao S, Mei Y, Chen S, Liu J, Zhang Y, Zhu Z and Zuo K: Potential therapeutic target in oncology: Protein palmitoylation (Review). Oncol Rep 54: 117, 2025.
APA
Hao, S., Mei, Y., Chen, S., Liu, J., Zhang, Y., Zhu, Z., & Zuo, K. (2025). Potential therapeutic target in oncology: Protein palmitoylation (Review). Oncology Reports, 54, 117. https://doi.org/10.3892/or.2025.8950
MLA
Hao, S., Mei, Y., Chen, S., Liu, J., Zhang, Y., Zhu, Z., Zuo, K."Potential therapeutic target in oncology: Protein palmitoylation (Review)". Oncology Reports 54.4 (2025): 117.
Chicago
Hao, S., Mei, Y., Chen, S., Liu, J., Zhang, Y., Zhu, Z., Zuo, K."Potential therapeutic target in oncology: Protein palmitoylation (Review)". Oncology Reports 54, no. 4 (2025): 117. https://doi.org/10.3892/or.2025.8950