Open Access

O‑GlcNAcylation as an emerging molecular target for cholangiocarcinoma therapy (Review)

  • Authors:
    • Purin Charoensuksai
    • Siwanon Jirawatnotai
  • View Affiliations

  • Published online on: July 18, 2025     https://doi.org/10.3892/or.2025.8952
  • Article Number: 119
  • Copyright: © Charoensuksai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Aberrant O‑GlcNAcylation and the upregulation of O‑GlcNAc transferase (OGT) are key contributors to cancer pathogenesis and progression, driving hyperproliferative states and metastatic phenotypes. Targeting OGT may suppress cancer progression, positioning OGT and O‑GlcNAc signaling as compelling targets in cancer research. Cholangiocarcinoma (CCA), a rare yet highly aggressive malignancy of the bile duct system, represents a clinical challenge, underscored by its rising global mortality, poor survival outcomes and high recurrence rate, despite advances in awareness, diagnostics and therapeutic strategies. Consequently, there is need for novel therapeutic modalities. Hyperactive O‑GlcNAcylation and upregulation of OGT are observed in CCA, therefore, targeting protein O‑GlcNAcylation may have clinical potential. The present review aimed to summarize the impact of O‑GlcNAcylation on CCA and CCA‑relevant hallmarks of cancer including cell proliferation, metastasis, metabolic reprogramming, angiogenesis, programmed cell death and tumor‑associated inflammation. In areas where direct evidence in CCA is limited, insights from other gastrointestinal tract cancers may identify potential mechanistic connections, offering a broader context to guide future investigation. Furthermore, the viability of OGT and O‑GlcNAcylation as therapeutic targets is discussed.
View Figures
View References

Related Articles

Journal Cover

October-2025
Volume 54 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Charoensuksai P and Jirawatnotai S: O‑GlcNAcylation as an emerging molecular target for cholangiocarcinoma therapy (Review). Oncol Rep 54: 119, 2025.
APA
Charoensuksai, P., & Jirawatnotai, S. (2025). O‑GlcNAcylation as an emerging molecular target for cholangiocarcinoma therapy (Review). Oncology Reports, 54, 119. https://doi.org/10.3892/or.2025.8952
MLA
Charoensuksai, P., Jirawatnotai, S."O‑GlcNAcylation as an emerging molecular target for cholangiocarcinoma therapy (Review)". Oncology Reports 54.4 (2025): 119.
Chicago
Charoensuksai, P., Jirawatnotai, S."O‑GlcNAcylation as an emerging molecular target for cholangiocarcinoma therapy (Review)". Oncology Reports 54, no. 4 (2025): 119. https://doi.org/10.3892/or.2025.8952